Factors associated with sex differences in viral non-suppression in the Swedish InfCareHIV cohort : An observational real-world study
Lindh, Maria ; Brännström, Johanna ; Reepalu, Anton LU
; Svedhem, Veronica
and Mellgren, Åsa
(2024)
In HIV Medicine
- Abstract
Objectives: Women living with HIV are underrepresented in clinical trials assessing outcomes of antiretroviral treatment (ART), justifying the need for observational studies. We investigated differences in viral non-suppression between women and men in the Swedish InfCareHIV cohort and analysed results in relation to biological and socio-demographic variables and patient-reported outcome measures (PROMs). Methods: The study included people living with HIV (PLWH) aged ≥18 years, who initiated ART at least 6 months prior to inclusion. Data from the InfCareHIV registry 2011–2018 were collected. Associations between variables and HIV RNA ≥50 copies/mL were investigated in uni- and multivariable analyses using generalized estimating... (More)
Objectives: Women living with HIV are underrepresented in clinical trials assessing outcomes of antiretroviral treatment (ART), justifying the need for observational studies. We investigated differences in viral non-suppression between women and men in the Swedish InfCareHIV cohort and analysed results in relation to biological and socio-demographic variables and patient-reported outcome measures (PROMs). Methods: The study included people living with HIV (PLWH) aged ≥18 years, who initiated ART at least 6 months prior to inclusion. Data from the InfCareHIV registry 2011–2018 were collected. Associations between variables and HIV RNA ≥50 copies/mL were investigated in uni- and multivariable analyses using generalized estimating equations, providing relative risks (RRs) as effect size. Results: The study included 38% (n = 2981) women. Women were more likely to have HIV RNA ≥50 copies/mL than were men [RR = 1.20, 95% confidence interval (CI): 1.10–1.31]. After adjusting for origin and route of transmission, sex at birth was no longer associated with viral non-suppression. PROMs were available in 52.4% of PLWH, and items associated with viral non-suppression were impaired adherence in women (RR = 2.38, 95% CI: 1.79–3.17) and men (RR 1.84, 95% CI: 1.40–2.42), and experience of side effects in women (RR = 1.49, 95% CI: 1.10–2.02). Conclusions: This observational study found a 20% higher relative risk of viral non-suppression in women than in men and the difference was associated with socio-demographic factors. The associations between PROMs and viral non-suppression varied between women and men. PROMs are important health outcomes that may identify PLWH in need of support to achieve viral non-suppression.
(Less)
- author
- Lindh, Maria
; Brännström, Johanna
; Reepalu, Anton
LU
; Svedhem, Veronica
and Mellgren, Åsa
- organization
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- in press
- subject
- keywords
- HIV, PROMs, viral non-suppression, women
- in
- HIV Medicine
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:38196293
- scopus:85181877472
- ISSN
- 1464-2662
- DOI
- 10.1111/hiv.13607
- language
- English
- LU publication?
- yes
- id
- 08abdaa5-e652-4388-b277-c4ddfb0f1e00
- date added to LUP
- 2024-02-12 10:55:44
- date last changed
- 2024-04-14 02:25:32
@article{08abdaa5-e652-4388-b277-c4ddfb0f1e00,
abstract = {{<p>Objectives: Women living with HIV are underrepresented in clinical trials assessing outcomes of antiretroviral treatment (ART), justifying the need for observational studies. We investigated differences in viral non-suppression between women and men in the Swedish InfCareHIV cohort and analysed results in relation to biological and socio-demographic variables and patient-reported outcome measures (PROMs). Methods: The study included people living with HIV (PLWH) aged ≥18 years, who initiated ART at least 6 months prior to inclusion. Data from the InfCareHIV registry 2011–2018 were collected. Associations between variables and HIV RNA ≥50 copies/mL were investigated in uni- and multivariable analyses using generalized estimating equations, providing relative risks (RRs) as effect size. Results: The study included 38% (n = 2981) women. Women were more likely to have HIV RNA ≥50 copies/mL than were men [RR = 1.20, 95% confidence interval (CI): 1.10–1.31]. After adjusting for origin and route of transmission, sex at birth was no longer associated with viral non-suppression. PROMs were available in 52.4% of PLWH, and items associated with viral non-suppression were impaired adherence in women (RR = 2.38, 95% CI: 1.79–3.17) and men (RR 1.84, 95% CI: 1.40–2.42), and experience of side effects in women (RR = 1.49, 95% CI: 1.10–2.02). Conclusions: This observational study found a 20% higher relative risk of viral non-suppression in women than in men and the difference was associated with socio-demographic factors. The associations between PROMs and viral non-suppression varied between women and men. PROMs are important health outcomes that may identify PLWH in need of support to achieve viral non-suppression.</p>}},
author = {{Lindh, Maria and Brännström, Johanna and Reepalu, Anton and Svedhem, Veronica and Mellgren, Åsa}},
issn = {{1464-2662}},
keywords = {{HIV; PROMs; viral non-suppression; women}},
language = {{eng}},
publisher = {{Wiley-Blackwell}},
series = {{HIV Medicine}},
title = {{Factors associated with sex differences in viral non-suppression in the Swedish InfCareHIV cohort : An observational real-world study}},
url = {{http://dx.doi.org/10.1111/hiv.13607}},
doi = {{10.1111/hiv.13607}},
year = {{2024}},
}