Proteome analysis of cerebrospinal fluid proteins in Alzheimer patients
(2002) In NeuroReport 13(5). p.5-611- Abstract
By comparing the CSF proteome between Alzheimer disease (AD) patients and controls it may be possible to identify proteins that play a role in the disease process and thus to study the pathogenesis of AD. We used mini-gel technology in a two-dimensional electrophoresis procedure, sensitive SYPRO Ruby staining and mass spectrometry for clinical screening of disease-influenced CSF proteins in 15 AD patients and 12 controls. The levels of six proteins and their isoforms, including proapolipoprotein, apolipoprotein E, beta-2 microglobulin, retinol-binding protein, transthyretin, and ubiquitin, were significantly altered in CSF of AD patients. The most prominently altered proteins were the apolipoproteins, especially proapolipoprotein.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/08b8df48-c0b4-4302-a7ac-8cb6e32fe4f9
- author
- Davidsson, Pia ; Westman-Brinkmalm, Ann ; Nilsson, Carol L LU ; Lindbjer, Maria ; Paulson, Linda ; Andreasen, Niels ; Sjögren, Magnus and Blennow, Kaj LU
- publishing date
- 2002-04-16
- type
- Contribution to journal
- publication status
- published
- keywords
- Aged, Aged, 80 and over, Alzheimer Disease, Confidence Intervals, Female, Humans, Longitudinal Studies, Male, Patients, Protein Isoforms, Proteins, Proteome, Statistics, Nonparametric, Comparative Study
- in
- NeuroReport
- volume
- 13
- issue
- 5
- pages
- 5 pages
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- scopus:0037117721
- pmid:11973456
- ISSN
- 0959-4965
- language
- English
- LU publication?
- no
- id
- 08b8df48-c0b4-4302-a7ac-8cb6e32fe4f9
- date added to LUP
- 2017-05-16 10:41:08
- date last changed
- 2024-06-09 16:40:53
@article{08b8df48-c0b4-4302-a7ac-8cb6e32fe4f9, abstract = {{<p>By comparing the CSF proteome between Alzheimer disease (AD) patients and controls it may be possible to identify proteins that play a role in the disease process and thus to study the pathogenesis of AD. We used mini-gel technology in a two-dimensional electrophoresis procedure, sensitive SYPRO Ruby staining and mass spectrometry for clinical screening of disease-influenced CSF proteins in 15 AD patients and 12 controls. The levels of six proteins and their isoforms, including proapolipoprotein, apolipoprotein E, beta-2 microglobulin, retinol-binding protein, transthyretin, and ubiquitin, were significantly altered in CSF of AD patients. The most prominently altered proteins were the apolipoproteins, especially proapolipoprotein.</p>}}, author = {{Davidsson, Pia and Westman-Brinkmalm, Ann and Nilsson, Carol L and Lindbjer, Maria and Paulson, Linda and Andreasen, Niels and Sjögren, Magnus and Blennow, Kaj}}, issn = {{0959-4965}}, keywords = {{Aged; Aged, 80 and over; Alzheimer Disease; Confidence Intervals; Female; Humans; Longitudinal Studies; Male; Patients; Protein Isoforms; Proteins; Proteome; Statistics, Nonparametric; Comparative Study}}, language = {{eng}}, month = {{04}}, number = {{5}}, pages = {{5--611}}, publisher = {{Lippincott Williams & Wilkins}}, series = {{NeuroReport}}, title = {{Proteome analysis of cerebrospinal fluid proteins in Alzheimer patients}}, volume = {{13}}, year = {{2002}}, }