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Clinical practice of BOTOX® treatment for overactive bladder syndrome in Sweden : an assessment of resource use and external validity

Gralén, Katarina; Elmér, Caroline; Broström, Eva W.; Althin, Rikard and Malmberg, Lars LU (2017) In Scandinavian Journal of Urology2013-01-01+01:00
Abstract

Objective: The objective of this study was to assess the resource use of treating overactive bladder (OAB) patients in real-world clinical practice and to evaluate whether there is external validity in the treatment of OAB in clinical practice. Materials and methods: The study included 55 patients suffering from OAB and treated with BOTOX® at two Swedish clinics. The study was conducted as an anonymized retrospective chart review study. Results: The estimated yearly direct cost of BOTOX treatment was €902. The mean age of patients in the study was 60 years, and 85% were women. The severity of OAB before BOTOX treatment, given by the mean number of daily leakages, equalled 4.8. The median interval between treatments was 210... (More)

Objective: The objective of this study was to assess the resource use of treating overactive bladder (OAB) patients in real-world clinical practice and to evaluate whether there is external validity in the treatment of OAB in clinical practice. Materials and methods: The study included 55 patients suffering from OAB and treated with BOTOX® at two Swedish clinics. The study was conducted as an anonymized retrospective chart review study. Results: The estimated yearly direct cost of BOTOX treatment was €902. The mean age of patients in the study was 60 years, and 85% were women. The severity of OAB before BOTOX treatment, given by the mean number of daily leakages, equalled 4.8. The median interval between treatments was 210 days. Conclusions: Patient characteristics in the real world were similar to those in the clinical trials, showing a high degree of external validity. Treatment intervals were longer in the real world than in clinical trials, indicating that treatment cost could be lower when patients are treated as observed in real-world clinical practice.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Botulinum toxin type A, external validity, overactive bladder syndrome, resource use
in
Scandinavian Journal of Urology2013-01-01+01:00
pages
5 pages
publisher
Taylor & Francis
external identifiers
  • scopus:85021874404
  • wos:000415626400011
ISSN
2168-1805
DOI
10.1080/21681805.2017.1334697
language
English
LU publication?
yes
id
08dc8fbe-40b9-4522-bd73-4f479b846619
date added to LUP
2017-07-26 07:39:16
date last changed
2018-01-16 13:21:47
@article{08dc8fbe-40b9-4522-bd73-4f479b846619,
  abstract     = {<p>Objective: The objective of this study was to assess the resource use of treating overactive bladder (OAB) patients in real-world clinical practice and to evaluate whether there is external validity in the treatment of OAB in clinical practice. Materials and methods: The study included 55 patients suffering from OAB and treated with BOTOX<sup>®</sup> at two Swedish clinics. The study was conducted as an anonymized retrospective chart review study. Results: The estimated yearly direct cost of BOTOX treatment was €902. The mean age of patients in the study was 60 years, and 85% were women. The severity of OAB before BOTOX treatment, given by the mean number of daily leakages, equalled 4.8. The median interval between treatments was 210 days. Conclusions: Patient characteristics in the real world were similar to those in the clinical trials, showing a high degree of external validity. Treatment intervals were longer in the real world than in clinical trials, indicating that treatment cost could be lower when patients are treated as observed in real-world clinical practice.</p>},
  author       = {Gralén, Katarina and Elmér, Caroline and Broström, Eva W. and Althin, Rikard and Malmberg, Lars},
  issn         = {2168-1805},
  keyword      = {Botulinum toxin type A,external validity,overactive bladder syndrome,resource use},
  language     = {eng},
  month        = {07},
  pages        = {5},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Urology2013-01-01+01:00},
  title        = {Clinical practice of BOTOX<sup>®</sup> treatment for overactive bladder syndrome in Sweden : an assessment of resource use and external validity},
  url          = {http://dx.doi.org/10.1080/21681805.2017.1334697},
  year         = {2017},
}