Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Prospective evaluation of β-cell function in insulin antoantibody-positive relatives of insulin-dependent diabetic patients

Neifing, James L. ; Greenbaum, Carla J. ; Kahn, Steven E. ; McCulloch, David K. ; Barmeier, Heike ; Lernmark, Åke LU orcid and Palmer, Jerry P. (1993) In Metabolism 42(4). p.482-486
Abstract

During the preclinical period of insulin-dependent diabetes mellitus (IDDM), progression to clinical IDDM is characterized by declining β-cell function. Although the presence of insulin autoantibodies (IAA) improves the ability of islet cell antibodies (ICA) to predict subsequent clinical IDDM, few studies have examined the risk of developing IDDM in subjects positive for IAA but negative for both ICA and antibodies to glutamic acid decarboxylase (64kA). To investigate this question, detailed β-cell function tests (acute insulin response to glucose [AIRgluc] and slope of glucose potentiation) were performed on eight IAA-positive first-degree relatives of insulin-dependent diabetics. All eight subjects were negative for ICA,... (More)

During the preclinical period of insulin-dependent diabetes mellitus (IDDM), progression to clinical IDDM is characterized by declining β-cell function. Although the presence of insulin autoantibodies (IAA) improves the ability of islet cell antibodies (ICA) to predict subsequent clinical IDDM, few studies have examined the risk of developing IDDM in subjects positive for IAA but negative for both ICA and antibodies to glutamic acid decarboxylase (64kA). To investigate this question, detailed β-cell function tests (acute insulin response to glucose [AIRgluc] and slope of glucose potentiation) were performed on eight IAA-positive first-degree relatives of insulin-dependent diabetics. All eight subjects were negative for ICA, and seven were tested for 64kA and were negative. Five subjects were studied prospectively for 22.4 ± 9.4 months, while three subjects had only initial studies. Initial β-cell function tests were normal in each subject. AIRgluc was 122.2% ± 19.0% of the expected normal response, while slope was 168.6% ± 20.6% of expected normal response. β-cell function remained normal and remarkably stable in the five subjects followed prospectively. AIRgluc did not significantly change from an initial value of 147.9% ± 23.1% of expected to 153.2% ± 22.4% (NS). The slope of glucose potentiation varied little from 165.5% ± 39.4% initially to 159.5% ± 27.3% (NS) at the most recent determination. We conclude that among nondiabetic first-degree relatives of IDDM subjects, the presence of IAA in the absence of ICA and 64kA is not usually associated with and therefore does not reliably predict β-cell dysfunction or progressive deterioration in β-cell function.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
in
Metabolism
volume
42
issue
4
pages
482 - 486
publisher
Elsevier
external identifiers
  • pmid:8487672
  • scopus:0027530307
ISSN
0026-0495
DOI
10.1016/0026-0495(93)90107-Y
language
English
LU publication?
no
id
08e966a9-b3ec-4406-9fc8-29c5a22f0ecf
date added to LUP
2019-09-11 09:25:05
date last changed
2024-03-13 08:22:44
@article{08e966a9-b3ec-4406-9fc8-29c5a22f0ecf,
  abstract     = {{<p>During the preclinical period of insulin-dependent diabetes mellitus (IDDM), progression to clinical IDDM is characterized by declining β-cell function. Although the presence of insulin autoantibodies (IAA) improves the ability of islet cell antibodies (ICA) to predict subsequent clinical IDDM, few studies have examined the risk of developing IDDM in subjects positive for IAA but negative for both ICA and antibodies to glutamic acid decarboxylase (64kA). To investigate this question, detailed β-cell function tests (acute insulin response to glucose [AIR<sub>gluc</sub>] and slope of glucose potentiation) were performed on eight IAA-positive first-degree relatives of insulin-dependent diabetics. All eight subjects were negative for ICA, and seven were tested for 64kA and were negative. Five subjects were studied prospectively for 22.4 ± 9.4 months, while three subjects had only initial studies. Initial β-cell function tests were normal in each subject. AIR<sub>gluc</sub> was 122.2% ± 19.0% of the expected normal response, while slope was 168.6% ± 20.6% of expected normal response. β-cell function remained normal and remarkably stable in the five subjects followed prospectively. AIR<sub>gluc</sub> did not significantly change from an initial value of 147.9% ± 23.1% of expected to 153.2% ± 22.4% (NS). The slope of glucose potentiation varied little from 165.5% ± 39.4% initially to 159.5% ± 27.3% (NS) at the most recent determination. We conclude that among nondiabetic first-degree relatives of IDDM subjects, the presence of IAA in the absence of ICA and 64kA is not usually associated with and therefore does not reliably predict β-cell dysfunction or progressive deterioration in β-cell function.</p>}},
  author       = {{Neifing, James L. and Greenbaum, Carla J. and Kahn, Steven E. and McCulloch, David K. and Barmeier, Heike and Lernmark, Åke and Palmer, Jerry P.}},
  issn         = {{0026-0495}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{4}},
  pages        = {{482--486}},
  publisher    = {{Elsevier}},
  series       = {{Metabolism}},
  title        = {{Prospective evaluation of β-cell function in insulin antoantibody-positive relatives of insulin-dependent diabetic patients}},
  url          = {{http://dx.doi.org/10.1016/0026-0495(93)90107-Y}},
  doi          = {{10.1016/0026-0495(93)90107-Y}},
  volume       = {{42}},
  year         = {{1993}},
}