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Serum levels of a subset of cytokines show high interindividual variability and are not altered in rats transgenic for Huntington´s disease.

Nguyen, Huu Phuc ; Björkqvist, Maria LU ; Bode, Felix J ; Stephan, Michael and von Hörsten, Stephan (2010) In PLoS Currents 2.
Abstract
To evaluate whether cytokines are altered in peripheral blood of rats transgenic for the human Huntington´s disease mutation we investigated serum levels of GRO/KC, IL-1β, IL-13 and TNF-α at a symptomatic stage at 12 months of age. Overall serum levels of these cytokines were not significantly changed between transgenic HD rats and controls. Moreover, we observed a high interindividual variability. Our results indicate that these cytokines will be difficult to pursue as biomarkers in at least this rat model of HD.
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS Currents
volume
2
article number
RRN1190
publisher
Public Library of Science
external identifiers
  • pmid:20981129
  • scopus:84873337254
  • pmid:20981129
ISSN
2157-3999
DOI
10.1371/currents.RRN1190
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041)
id
08f77473-f58c-4e91-9629-5c6112cbca7d (old id 1710672)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20981129?dopt=Abstract
date added to LUP
2016-04-04 09:45:01
date last changed
2020-03-11 06:04:31
@article{08f77473-f58c-4e91-9629-5c6112cbca7d,
  abstract     = {To evaluate whether cytokines are altered in peripheral blood of rats transgenic for the human Huntington´s disease mutation we investigated serum levels of GRO/KC, IL-1β, IL-13 and TNF-α at a symptomatic stage at 12 months of age. Overall serum levels of these cytokines were not significantly changed between transgenic HD rats and controls. Moreover, we observed a high interindividual variability. Our results indicate that these cytokines will be difficult to pursue as biomarkers in at least this rat model of HD.},
  author       = {Nguyen, Huu Phuc and Björkqvist, Maria and Bode, Felix J and Stephan, Michael and von Hörsten, Stephan},
  issn         = {2157-3999},
  language     = {eng},
  publisher    = {Public Library of Science},
  series       = {PLoS Currents},
  title        = {Serum levels of a subset of cytokines show high interindividual variability and are not altered in rats transgenic for Huntington´s disease.},
  url          = {http://dx.doi.org/10.1371/currents.RRN1190},
  doi          = {10.1371/currents.RRN1190},
  volume       = {2},
  year         = {2010},
}