Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Serum levels of a subset of cytokines show high interindividual variability and are not altered in rats transgenic for Huntington´s disease.

Nguyen, Huu Phuc ; Björkqvist, Maria LU orcid ; Bode, Felix J ; Stephan, Michael and von Hörsten, Stephan (2010) In PLoS Currents 2.
Abstract
To evaluate whether cytokines are altered in peripheral blood of rats transgenic for the human Huntington´s disease mutation we investigated serum levels of GRO/KC, IL-1β, IL-13 and TNF-α at a symptomatic stage at 12 months of age. Overall serum levels of these cytokines were not significantly changed between transgenic HD rats and controls. Moreover, we observed a high interindividual variability. Our results indicate that these cytokines will be difficult to pursue as biomarkers in at least this rat model of HD.
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS Currents
volume
2
article number
RRN1190
publisher
Public Library of Science (PLoS)
external identifiers
  • pmid:20981129
  • scopus:84873337254
  • pmid:20981129
ISSN
2157-3999
DOI
10.1371/currents.RRN1190
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041)
id
08f77473-f58c-4e91-9629-5c6112cbca7d (old id 1710672)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20981129?dopt=Abstract
date added to LUP
2016-04-04 09:45:01
date last changed
2023-09-06 03:38:12
@article{08f77473-f58c-4e91-9629-5c6112cbca7d,
  abstract     = {{To evaluate whether cytokines are altered in peripheral blood of rats transgenic for the human Huntington´s disease mutation we investigated serum levels of GRO/KC, IL-1β, IL-13 and TNF-α at a symptomatic stage at 12 months of age. Overall serum levels of these cytokines were not significantly changed between transgenic HD rats and controls. Moreover, we observed a high interindividual variability. Our results indicate that these cytokines will be difficult to pursue as biomarkers in at least this rat model of HD.}},
  author       = {{Nguyen, Huu Phuc and Björkqvist, Maria and Bode, Felix J and Stephan, Michael and von Hörsten, Stephan}},
  issn         = {{2157-3999}},
  language     = {{eng}},
  publisher    = {{Public Library of Science (PLoS)}},
  series       = {{PLoS Currents}},
  title        = {{Serum levels of a subset of cytokines show high interindividual variability and are not altered in rats transgenic for Huntington´s disease.}},
  url          = {{http://dx.doi.org/10.1371/currents.RRN1190}},
  doi          = {{10.1371/currents.RRN1190}},
  volume       = {{2}},
  year         = {{2010}},
}