Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche
Yamazaki, Satoshi ; Ema, Hideo ; Karlsson, Göran LU ; Yamaguchi, Tomoyuki ; Miyoshi, Hiroyuki ; Shioda, Seiji ; Taketo, Makoto M. ; Karlsson, Stefan LU
; Iwama, Atsushi
and Nakauchi, Hiromitsu
(2011)
In Cell
147(5).
p.1146-1158
- Abstract
- Hematopoietic stem cells (HSCs) reside and self-renew in the bone marrow (BM) niche. Overall, the signaling that regulates stem cell dormancy in the HSC niche remains controversial. Here, we demonstrate that TGF-beta type II receptor-deficient HSCs show low-level Smad activation and impaired long-term repopulating activity, underlining the critical role of TGF-beta/Smad signaling in HSC maintenance. TGF-b is produced as a latent form by a variety of cells, so we searched for those that express activator molecules for latent TGF-beta. Nonmyelinating Schwann cells in BM proved responsible for activation. These glial cells ensheathed autonomic nerves, expressed HSC niche factor genes, and were in contact with a substantial proportion of HSCs.... (More)
- Hematopoietic stem cells (HSCs) reside and self-renew in the bone marrow (BM) niche. Overall, the signaling that regulates stem cell dormancy in the HSC niche remains controversial. Here, we demonstrate that TGF-beta type II receptor-deficient HSCs show low-level Smad activation and impaired long-term repopulating activity, underlining the critical role of TGF-beta/Smad signaling in HSC maintenance. TGF-b is produced as a latent form by a variety of cells, so we searched for those that express activator molecules for latent TGF-beta. Nonmyelinating Schwann cells in BM proved responsible for activation. These glial cells ensheathed autonomic nerves, expressed HSC niche factor genes, and were in contact with a substantial proportion of HSCs. Autonomic nerve denervation reduced the number of these active TGF-beta-producing cells and led to rapid loss of HSCs from BM. We propose that glial cells are components of a BM niche and maintain HSC hibernation by regulating activation of latent TGF-beta. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2272183
- author
- Yamazaki, Satoshi
; Ema, Hideo
; Karlsson, Göran
LU
; Yamaguchi, Tomoyuki
; Miyoshi, Hiroyuki
; Shioda, Seiji
; Taketo, Makoto M.
; Karlsson, Stefan
LU
; Iwama, Atsushi
and Nakauchi, Hiromitsu
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cell
- volume
- 147
- issue
- 5
- pages
- 1146 - 1158
- publisher
- Cell Press
- external identifiers
-
- wos:000297376600024
- scopus:81855183667
- ISSN
- 1097-4172
- DOI
- 10.1016/j.cell.2011.09.053
- language
- English
- LU publication?
- yes
- id
- 0905f534-9d37-46af-842f-4fb3889d0e77 (old id 2272183)
- date added to LUP
- 2016-04-01 10:44:59
- date last changed
- 2022-04-20 05:35:21
@article{0905f534-9d37-46af-842f-4fb3889d0e77,
abstract = {{Hematopoietic stem cells (HSCs) reside and self-renew in the bone marrow (BM) niche. Overall, the signaling that regulates stem cell dormancy in the HSC niche remains controversial. Here, we demonstrate that TGF-beta type II receptor-deficient HSCs show low-level Smad activation and impaired long-term repopulating activity, underlining the critical role of TGF-beta/Smad signaling in HSC maintenance. TGF-b is produced as a latent form by a variety of cells, so we searched for those that express activator molecules for latent TGF-beta. Nonmyelinating Schwann cells in BM proved responsible for activation. These glial cells ensheathed autonomic nerves, expressed HSC niche factor genes, and were in contact with a substantial proportion of HSCs. Autonomic nerve denervation reduced the number of these active TGF-beta-producing cells and led to rapid loss of HSCs from BM. We propose that glial cells are components of a BM niche and maintain HSC hibernation by regulating activation of latent TGF-beta.}},
author = {{Yamazaki, Satoshi and Ema, Hideo and Karlsson, Göran and Yamaguchi, Tomoyuki and Miyoshi, Hiroyuki and Shioda, Seiji and Taketo, Makoto M. and Karlsson, Stefan and Iwama, Atsushi and Nakauchi, Hiromitsu}},
issn = {{1097-4172}},
language = {{eng}},
number = {{5}},
pages = {{1146--1158}},
publisher = {{Cell Press}},
series = {{Cell}},
title = {{Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche}},
url = {{http://dx.doi.org/10.1016/j.cell.2011.09.053}},
doi = {{10.1016/j.cell.2011.09.053}},
volume = {{147}},
year = {{2011}},
}