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The interaction of transcription factors controls the spatial layout of plant aerial stem cell niches

Gruel, Jérémy LU ; Deichmann, Julia; Landrein, Benoit; Hitchcock, Thomas and Jönsson, Henrik LU (2018) In npj Systems Biology and Applications 4(1).
Abstract

The plant shoot apical meristem holds a stem cell niche from which all aerial organs originate. Using a computational approach we show that a mixture of monomers and heterodimers of the transcription factors WUSCHEL and HAIRY MERISTEM is sufficient to pattern the stem cell niche, and predict that immobile heterodimers form a regulatory “pocket” surrounding the stem cells. The model achieves to reproduce an array of perturbations, including mutants and tissue size modifications. We also show its ability to reproduce the recently observed dynamical shift of the stem cell niche during the development of an axillary meristem. The work integrates recent experimental results to answer the longstanding question of how the asymmetry of... (More)

The plant shoot apical meristem holds a stem cell niche from which all aerial organs originate. Using a computational approach we show that a mixture of monomers and heterodimers of the transcription factors WUSCHEL and HAIRY MERISTEM is sufficient to pattern the stem cell niche, and predict that immobile heterodimers form a regulatory “pocket” surrounding the stem cells. The model achieves to reproduce an array of perturbations, including mutants and tissue size modifications. We also show its ability to reproduce the recently observed dynamical shift of the stem cell niche during the development of an axillary meristem. The work integrates recent experimental results to answer the longstanding question of how the asymmetry of expression between the stem cell marker CLAVATA3 and its activator WUSCHEL is achieved, and recent findings of plasticity in the system.

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publication status
published
subject
in
npj Systems Biology and Applications
volume
4
issue
1
external identifiers
  • scopus:85052939319
DOI
10.1038/s41540-018-0072-1
language
English
LU publication?
yes
id
094db5e9-7a65-4049-b1f8-7b294b3d416b
date added to LUP
2018-10-08 11:54:20
date last changed
2019-02-20 11:29:55
@article{094db5e9-7a65-4049-b1f8-7b294b3d416b,
  abstract     = {<p>The plant shoot apical meristem holds a stem cell niche from which all aerial organs originate. Using a computational approach we show that a mixture of monomers and heterodimers of the transcription factors WUSCHEL and HAIRY MERISTEM is sufficient to pattern the stem cell niche, and predict that immobile heterodimers form a regulatory “pocket” surrounding the stem cells. The model achieves to reproduce an array of perturbations, including mutants and tissue size modifications. We also show its ability to reproduce the recently observed dynamical shift of the stem cell niche during the development of an axillary meristem. The work integrates recent experimental results to answer the longstanding question of how the asymmetry of expression between the stem cell marker CLAVATA3 and its activator WUSCHEL is achieved, and recent findings of plasticity in the system.</p>},
  articleno    = {36},
  author       = {Gruel, Jérémy and Deichmann, Julia and Landrein, Benoit and Hitchcock, Thomas and Jönsson, Henrik},
  language     = {eng},
  number       = {1},
  series       = {npj Systems Biology and Applications},
  title        = {The interaction of transcription factors controls the spatial layout of plant aerial stem cell niches},
  url          = {http://dx.doi.org/10.1038/s41540-018-0072-1},
  volume       = {4},
  year         = {2018},
}