Association between autoantibody markers and subtypes of DR4 and DR4-DQ in Swedish children with insulin-dependent diabetes reveals closer association of tyrosine pyrophosphatase autoimmunity with DR4 than DQ8
(1998) In Tissue Antigens 51(3). p.281-286- Abstract
HLA DQA1(*)0301-DQB1(*)0302 (DQ8) and DQA1(*)0501-DQB1(*)0201 (DQ2) are positively and DQA1(*)0102-DQB1(*)0602 (DQ6) negatively associated with IDDM. In DQA1(*)0301-DQB1(*)0302 (DQ8)-positive patients, susceptibility is also mediated by DRB1(*)0401. The aim of the study was to determine the association between HLA-DR4 and DQ and the presence of GAD65, ICA512, and insulin autoantibodies as well as ICA in 425 Swedish children with IDDM and 367 controls in the age group of 0-15 years. We found that ICA512 autoantibodies were associated primarily with DRB1(*)0401 and not with DQA1(*)0301-DQB1(*)0302 (DQ8). No such hierarchy could be demonstrated for insulin autoantibodies, which were associated with both DQA1(*)0301-DQB1(*)0302 (DQ8) and... (More)
HLA DQA1(*)0301-DQB1(*)0302 (DQ8) and DQA1(*)0501-DQB1(*)0201 (DQ2) are positively and DQA1(*)0102-DQB1(*)0602 (DQ6) negatively associated with IDDM. In DQA1(*)0301-DQB1(*)0302 (DQ8)-positive patients, susceptibility is also mediated by DRB1(*)0401. The aim of the study was to determine the association between HLA-DR4 and DQ and the presence of GAD65, ICA512, and insulin autoantibodies as well as ICA in 425 Swedish children with IDDM and 367 controls in the age group of 0-15 years. We found that ICA512 autoantibodies were associated primarily with DRB1(*)0401 and not with DQA1(*)0301-DQB1(*)0302 (DQ8). No such hierarchy could be demonstrated for insulin autoantibodies, which were associated with both DQA1(*)0301-DQB1(*)0302 (DQ8) and DRB1(*)0401. GAD65 autoantibodies, known to be closely associated with DQA1(*)0501-DQB1(*)0201 (DQ2)-DRB1(*)0301 haplotype, also showed no preferential association with DQA1(*)0301-DQB1(*)0302 (DQ8) versus DRB1(*)04. These results suggest that the immune response to different β-cell autoantigens may be mediated via HLA class II molecules from different loci. Design of the antigen-specific immuno-intervention trials should take into account these HLA-DR and DQ subtype associations.
(Less)
- author
- Sanjeevi, C. B. ; Hagopian, W. A. ; Landin-Olsson, M. LU ; Kockum, I. ; Woo, W. ; Palmer, J. P. ; Lernmark, Å LU and Dahlquist, G.
- organization
- publishing date
- 1998-03-25
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- DQ, GAD65 autoantibodies, HLA-DR, ICA, ICA512 autoantibodies, IDDM, Insulin autoantibodies
- in
- Tissue Antigens
- volume
- 51
- issue
- 3
- pages
- 281 - 286
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:9550329
- scopus:0031935660
- ISSN
- 0001-2815
- DOI
- 10.1111/j.1399-0039.1998.tb03103.x
- language
- English
- LU publication?
- yes
- id
- 09686c63-a489-4023-8add-d2a812b1bb1c
- date added to LUP
- 2019-06-30 23:43:05
- date last changed
- 2024-03-13 08:05:29
@article{09686c63-a489-4023-8add-d2a812b1bb1c, abstract = {{<p>HLA DQA1(*)0301-DQB1(*)0302 (DQ8) and DQA1(*)0501-DQB1(*)0201 (DQ2) are positively and DQA1(*)0102-DQB1(*)0602 (DQ6) negatively associated with IDDM. In DQA1(*)0301-DQB1(*)0302 (DQ8)-positive patients, susceptibility is also mediated by DRB1(*)0401. The aim of the study was to determine the association between HLA-DR4 and DQ and the presence of GAD65, ICA512, and insulin autoantibodies as well as ICA in 425 Swedish children with IDDM and 367 controls in the age group of 0-15 years. We found that ICA512 autoantibodies were associated primarily with DRB1(*)0401 and not with DQA1(*)0301-DQB1(*)0302 (DQ8). No such hierarchy could be demonstrated for insulin autoantibodies, which were associated with both DQA1(*)0301-DQB1(*)0302 (DQ8) and DRB1(*)0401. GAD65 autoantibodies, known to be closely associated with DQA1(*)0501-DQB1(*)0201 (DQ2)-DRB1(*)0301 haplotype, also showed no preferential association with DQA1(*)0301-DQB1(*)0302 (DQ8) versus DRB1(*)04. These results suggest that the immune response to different β-cell autoantigens may be mediated via HLA class II molecules from different loci. Design of the antigen-specific immuno-intervention trials should take into account these HLA-DR and DQ subtype associations.</p>}}, author = {{Sanjeevi, C. B. and Hagopian, W. A. and Landin-Olsson, M. and Kockum, I. and Woo, W. and Palmer, J. P. and Lernmark, Å and Dahlquist, G.}}, issn = {{0001-2815}}, keywords = {{DQ; GAD65 autoantibodies; HLA-DR; ICA; ICA512 autoantibodies; IDDM; Insulin autoantibodies}}, language = {{eng}}, month = {{03}}, number = {{3}}, pages = {{281--286}}, publisher = {{Wiley-Blackwell}}, series = {{Tissue Antigens}}, title = {{Association between autoantibody markers and subtypes of DR4 and DR4-DQ in Swedish children with insulin-dependent diabetes reveals closer association of tyrosine pyrophosphatase autoimmunity with DR4 than DQ8}}, url = {{http://dx.doi.org/10.1111/j.1399-0039.1998.tb03103.x}}, doi = {{10.1111/j.1399-0039.1998.tb03103.x}}, volume = {{51}}, year = {{1998}}, }