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Association between autoantibody markers and subtypes of DR4 and DR4-DQ in Swedish children with insulin-dependent diabetes reveals closer association of tyrosine pyrophosphatase autoimmunity with DR4 than DQ8

Sanjeevi, C. B. ; Hagopian, W. A. ; Landin-Olsson, M. LU ; Kockum, I. ; Woo, W. ; Palmer, J. P. ; Lernmark, Å LU orcid and Dahlquist, G. (1998) In Tissue Antigens 51(3). p.281-286
Abstract

HLA DQA1(*)0301-DQB1(*)0302 (DQ8) and DQA1(*)0501-DQB1(*)0201 (DQ2) are positively and DQA1(*)0102-DQB1(*)0602 (DQ6) negatively associated with IDDM. In DQA1(*)0301-DQB1(*)0302 (DQ8)-positive patients, susceptibility is also mediated by DRB1(*)0401. The aim of the study was to determine the association between HLA-DR4 and DQ and the presence of GAD65, ICA512, and insulin autoantibodies as well as ICA in 425 Swedish children with IDDM and 367 controls in the age group of 0-15 years. We found that ICA512 autoantibodies were associated primarily with DRB1(*)0401 and not with DQA1(*)0301-DQB1(*)0302 (DQ8). No such hierarchy could be demonstrated for insulin autoantibodies, which were associated with both DQA1(*)0301-DQB1(*)0302 (DQ8) and... (More)

HLA DQA1(*)0301-DQB1(*)0302 (DQ8) and DQA1(*)0501-DQB1(*)0201 (DQ2) are positively and DQA1(*)0102-DQB1(*)0602 (DQ6) negatively associated with IDDM. In DQA1(*)0301-DQB1(*)0302 (DQ8)-positive patients, susceptibility is also mediated by DRB1(*)0401. The aim of the study was to determine the association between HLA-DR4 and DQ and the presence of GAD65, ICA512, and insulin autoantibodies as well as ICA in 425 Swedish children with IDDM and 367 controls in the age group of 0-15 years. We found that ICA512 autoantibodies were associated primarily with DRB1(*)0401 and not with DQA1(*)0301-DQB1(*)0302 (DQ8). No such hierarchy could be demonstrated for insulin autoantibodies, which were associated with both DQA1(*)0301-DQB1(*)0302 (DQ8) and DRB1(*)0401. GAD65 autoantibodies, known to be closely associated with DQA1(*)0501-DQB1(*)0201 (DQ2)-DRB1(*)0301 haplotype, also showed no preferential association with DQA1(*)0301-DQB1(*)0302 (DQ8) versus DRB1(*)04. These results suggest that the immune response to different β-cell autoantigens may be mediated via HLA class II molecules from different loci. Design of the antigen-specific immuno-intervention trials should take into account these HLA-DR and DQ subtype associations.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
DQ, GAD65 autoantibodies, HLA-DR, ICA, ICA512 autoantibodies, IDDM, Insulin autoantibodies
in
Tissue Antigens
volume
51
issue
3
pages
281 - 286
publisher
Wiley-Blackwell
external identifiers
  • scopus:0031935660
  • pmid:9550329
ISSN
0001-2815
DOI
10.1111/j.1399-0039.1998.tb03103.x
language
English
LU publication?
yes
id
09686c63-a489-4023-8add-d2a812b1bb1c
date added to LUP
2019-06-30 23:43:05
date last changed
2024-03-13 08:05:29
@article{09686c63-a489-4023-8add-d2a812b1bb1c,
  abstract     = {{<p>HLA DQA1(*)0301-DQB1(*)0302 (DQ8) and DQA1(*)0501-DQB1(*)0201 (DQ2) are positively and DQA1(*)0102-DQB1(*)0602 (DQ6) negatively associated with IDDM. In DQA1(*)0301-DQB1(*)0302 (DQ8)-positive patients, susceptibility is also mediated by DRB1(*)0401. The aim of the study was to determine the association between HLA-DR4 and DQ and the presence of GAD65, ICA512, and insulin autoantibodies as well as ICA in 425 Swedish children with IDDM and 367 controls in the age group of 0-15 years. We found that ICA512 autoantibodies were associated primarily with DRB1(*)0401 and not with DQA1(*)0301-DQB1(*)0302 (DQ8). No such hierarchy could be demonstrated for insulin autoantibodies, which were associated with both DQA1(*)0301-DQB1(*)0302 (DQ8) and DRB1(*)0401. GAD65 autoantibodies, known to be closely associated with DQA1(*)0501-DQB1(*)0201 (DQ2)-DRB1(*)0301 haplotype, also showed no preferential association with DQA1(*)0301-DQB1(*)0302 (DQ8) versus DRB1(*)04. These results suggest that the immune response to different β-cell autoantigens may be mediated via HLA class II molecules from different loci. Design of the antigen-specific immuno-intervention trials should take into account these HLA-DR and DQ subtype associations.</p>}},
  author       = {{Sanjeevi, C. B. and Hagopian, W. A. and Landin-Olsson, M. and Kockum, I. and Woo, W. and Palmer, J. P. and Lernmark, Å and Dahlquist, G.}},
  issn         = {{0001-2815}},
  keywords     = {{DQ; GAD65 autoantibodies; HLA-DR; ICA; ICA512 autoantibodies; IDDM; Insulin autoantibodies}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{3}},
  pages        = {{281--286}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Tissue Antigens}},
  title        = {{Association between autoantibody markers and subtypes of DR4 and DR4-DQ in Swedish children with insulin-dependent diabetes reveals closer association of tyrosine pyrophosphatase autoimmunity with DR4 than DQ8}},
  url          = {{http://dx.doi.org/10.1111/j.1399-0039.1998.tb03103.x}},
  doi          = {{10.1111/j.1399-0039.1998.tb03103.x}},
  volume       = {{51}},
  year         = {{1998}},
}