Hybrid heterogeneous phantoms for biomedical applications: a demonstration to dosimetry validation
(2024) In Biomedical Optics Express 15(2). p.863-874- Abstract
- Phantoms simultaneously mimicking anatomical and optical properties of real tissues can play a pivotal role for improving dosimetry algorithms. The aim of the paper is to design and develop a hybrid phantom model that builds up on the strengths of solid and liquid phantoms for mimicking various anatomical structures for prostate cancer photodynamic therapy (PDT) dosimetry validation. The model comprises of a photosensitizer-embedded gelatin lesion within a liquid Intralipid prostate shape that is surrounded by a solid silicone outer shell. The hybrid phantom was well characterized for optical properties. The final assembled phantom was also evaluated for fluorescence tomographic reconstruction in conjunction with SpectraCure’s IDOSE... (More)
- Phantoms simultaneously mimicking anatomical and optical properties of real tissues can play a pivotal role for improving dosimetry algorithms. The aim of the paper is to design and develop a hybrid phantom model that builds up on the strengths of solid and liquid phantoms for mimicking various anatomical structures for prostate cancer photodynamic therapy (PDT) dosimetry validation. The model comprises of a photosensitizer-embedded gelatin lesion within a liquid Intralipid prostate shape that is surrounded by a solid silicone outer shell. The hybrid phantom was well characterized for optical properties. The final assembled phantom was also evaluated for fluorescence tomographic reconstruction in conjunction with SpectraCure’s IDOSE software. The developed model can lead to advancements in dosimetric evaluations. This would improve PDT outlook as a clinical treatment modality and boost phantom based standardization of biophotonic devices globally. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/09ab8daf-aacf-4627-bb47-0dba303a888f
- author
- Ghauri, Muhammad Daniyal ; Susnjar, Stefan LU ; Guadagno, Claudia Nunzia ; Bhattacharya, Somdatta ; Thomasson, Björn ; Swartling, Johannes ; Gautam, Rekha ; Andersson-Engels, Stefan and Sekar, Sanathana Konugolu Venkata
- organization
- publishing date
- 2024-01-18
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Biomedical Optics Express
- volume
- 15
- issue
- 2
- pages
- 11 pages
- publisher
- Optical Society of America
- external identifiers
-
- scopus:85184141568
- ISSN
- 2156-7085
- DOI
- 10.1364/BOE.514994
- language
- English
- LU publication?
- yes
- id
- 09ab8daf-aacf-4627-bb47-0dba303a888f
- date added to LUP
- 2024-02-07 10:18:17
- date last changed
- 2024-03-12 13:15:43
@article{09ab8daf-aacf-4627-bb47-0dba303a888f, abstract = {{Phantoms simultaneously mimicking anatomical and optical properties of real tissues can play a pivotal role for improving dosimetry algorithms. The aim of the paper is to design and develop a hybrid phantom model that builds up on the strengths of solid and liquid phantoms for mimicking various anatomical structures for prostate cancer photodynamic therapy (PDT) dosimetry validation. The model comprises of a photosensitizer-embedded gelatin lesion within a liquid Intralipid prostate shape that is surrounded by a solid silicone outer shell. The hybrid phantom was well characterized for optical properties. The final assembled phantom was also evaluated for fluorescence tomographic reconstruction in conjunction with SpectraCure’s IDOSE software. The developed model can lead to advancements in dosimetric evaluations. This would improve PDT outlook as a clinical treatment modality and boost phantom based standardization of biophotonic devices globally.}}, author = {{Ghauri, Muhammad Daniyal and Susnjar, Stefan and Guadagno, Claudia Nunzia and Bhattacharya, Somdatta and Thomasson, Björn and Swartling, Johannes and Gautam, Rekha and Andersson-Engels, Stefan and Sekar, Sanathana Konugolu Venkata}}, issn = {{2156-7085}}, language = {{eng}}, month = {{01}}, number = {{2}}, pages = {{863--874}}, publisher = {{Optical Society of America}}, series = {{Biomedical Optics Express}}, title = {{Hybrid heterogeneous phantoms for biomedical applications: a demonstration to dosimetry validation}}, url = {{http://dx.doi.org/10.1364/BOE.514994}}, doi = {{10.1364/BOE.514994}}, volume = {{15}}, year = {{2024}}, }