Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Hybrid heterogeneous phantoms for biomedical applications: a demonstration to dosimetry validation

Ghauri, Muhammad Daniyal ; Susnjar, Stefan LU ; Guadagno, Claudia Nunzia ; Bhattacharya, Somdatta ; Thomasson, Björn ; Swartling, Johannes ; Gautam, Rekha ; Andersson-Engels, Stefan and Sekar, Sanathana Konugolu Venkata (2024) In Biomedical Optics Express 15(2). p.863-874
Abstract
Phantoms simultaneously mimicking anatomical and optical properties of real tissues can play a pivotal role for improving dosimetry algorithms. The aim of the paper is to design and develop a hybrid phantom model that builds up on the strengths of solid and liquid phantoms for mimicking various anatomical structures for prostate cancer photodynamic therapy (PDT) dosimetry validation. The model comprises of a photosensitizer-embedded gelatin lesion within a liquid Intralipid prostate shape that is surrounded by a solid silicone outer shell. The hybrid phantom was well characterized for optical properties. The final assembled phantom was also evaluated for fluorescence tomographic reconstruction in conjunction with SpectraCure’s IDOSE... (More)
Phantoms simultaneously mimicking anatomical and optical properties of real tissues can play a pivotal role for improving dosimetry algorithms. The aim of the paper is to design and develop a hybrid phantom model that builds up on the strengths of solid and liquid phantoms for mimicking various anatomical structures for prostate cancer photodynamic therapy (PDT) dosimetry validation. The model comprises of a photosensitizer-embedded gelatin lesion within a liquid Intralipid prostate shape that is surrounded by a solid silicone outer shell. The hybrid phantom was well characterized for optical properties. The final assembled phantom was also evaluated for fluorescence tomographic reconstruction in conjunction with SpectraCure’s IDOSE software. The developed model can lead to advancements in dosimetric evaluations. This would improve PDT outlook as a clinical treatment modality and boost phantom based standardization of biophotonic devices globally. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biomedical Optics Express
volume
15
issue
2
pages
11 pages
publisher
Optical Society of America
external identifiers
  • scopus:85184141568
ISSN
2156-7085
DOI
10.1364/BOE.514994
language
English
LU publication?
yes
id
09ab8daf-aacf-4627-bb47-0dba303a888f
date added to LUP
2024-02-07 10:18:17
date last changed
2024-03-12 13:15:43
@article{09ab8daf-aacf-4627-bb47-0dba303a888f,
  abstract     = {{Phantoms simultaneously mimicking anatomical and optical properties of real tissues can play a pivotal role for improving dosimetry algorithms. The aim of the paper is to design and develop a hybrid phantom model that builds up on the strengths of solid and liquid phantoms for mimicking various anatomical structures for prostate cancer photodynamic therapy (PDT) dosimetry validation. The model comprises of a photosensitizer-embedded gelatin lesion within a liquid Intralipid prostate shape that is surrounded by a solid silicone outer shell. The hybrid phantom was well characterized for optical properties. The final assembled phantom was also evaluated for fluorescence tomographic reconstruction in conjunction with SpectraCure’s IDOSE software. The developed model can lead to advancements in dosimetric evaluations. This would improve PDT outlook as a clinical treatment modality and boost phantom based standardization of biophotonic devices globally.}},
  author       = {{Ghauri, Muhammad Daniyal and Susnjar, Stefan and Guadagno, Claudia Nunzia and Bhattacharya, Somdatta and Thomasson, Björn and Swartling, Johannes and Gautam, Rekha and Andersson-Engels, Stefan and Sekar, Sanathana Konugolu Venkata}},
  issn         = {{2156-7085}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{2}},
  pages        = {{863--874}},
  publisher    = {{Optical Society of America}},
  series       = {{Biomedical Optics Express}},
  title        = {{Hybrid heterogeneous phantoms for biomedical applications: a demonstration to dosimetry validation}},
  url          = {{http://dx.doi.org/10.1364/BOE.514994}},
  doi          = {{10.1364/BOE.514994}},
  volume       = {{15}},
  year         = {{2024}},
}