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Grafts of Embryonic Dopamine Neurons in Rodent Models of Parkinson's Disease

Brundin, Patrik LU ; Emgård, Mia LU ; Mundt-Petersen, Ulrika LU and Emgård, Mia LU (1999) p.299-299
Abstract
This chapter exemplifies rodent models of Parkinson's disease that have been used in transplantation studies and recounts basic transplantation methods. It describes morphological features of grafts containing dopamine neurons and focuses on the role of nigral grafts that are implanted homotopically in the mesencephalon, for example, near their location in the normal brain. The neurotoxin 6-hydroxydopamine (OHDA) is selectively taken up by catecholaminergic neurons and kills them through a mechanism that is still not fully elucidated, but may well include oxidative stress. When injected in adequate amounts into the brain, it can cause extensive and permanent damage to catecholaminergic neurons, such as those giving rise to the... (More)
This chapter exemplifies rodent models of Parkinson's disease that have been used in transplantation studies and recounts basic transplantation methods. It describes morphological features of grafts containing dopamine neurons and focuses on the role of nigral grafts that are implanted homotopically in the mesencephalon, for example, near their location in the normal brain. The neurotoxin 6-hydroxydopamine (OHDA) is selectively taken up by catecholaminergic neurons and kills them through a mechanism that is still not fully elucidated, but may well include oxidative stress. When injected in adequate amounts into the brain, it can cause extensive and permanent damage to catecholaminergic neurons, such as those giving rise to the nigrostriatal pathway. The survival of dopamine neurons placed in a 6-OHDA denervated striatum is reflected by restoration of striatal dopamine levels to around 10 to 30% of normal. Examination of the ratio between levels of the dopamine metabolite DOPAC and dopamine reveals ratios that are 50 to 200% higher in grafted striata compared to normal, suggesting that the grafted neurons have an increased transmitter turnover (Less)
Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
graft survival, Basic science, Intracerebral grafts, Huntington's disease cell therapy, Parkinson's disease cell therapy
host publication
CNS regeneration: Basic Science and Clinical Applications
pages
320 pages
publisher
Academic Press
ISBN
9780127050706
language
English
LU publication?
yes
id
09af88aa-6e00-4257-85e1-7277a5ee042b
alternative location
https://www.sciencedirect.com/science/article/pii/B9780127050706500123
date added to LUP
2023-02-03 14:35:13
date last changed
2023-02-06 15:27:45
@inbook{09af88aa-6e00-4257-85e1-7277a5ee042b,
  abstract     = {{This chapter exemplifies rodent models of Parkinson's disease that have been used in transplantation studies and recounts basic transplantation methods. It describes morphological features of grafts containing dopamine neurons and focuses on the role of nigral grafts that are implanted homotopically in the mesencephalon, for example, near their location in the normal brain. The neurotoxin 6-hydroxydopamine (OHDA) is selectively taken up by catecholaminergic neurons and kills them through a mechanism that is still not fully elucidated, but may well include oxidative stress. When injected in adequate amounts into the brain, it can cause extensive and permanent damage to catecholaminergic neurons, such as those giving rise to the nigrostriatal pathway. The survival of dopamine neurons placed in a 6-OHDA denervated striatum is reflected by restoration of striatal dopamine levels to around 10 to 30% of normal. Examination of the ratio between levels of the dopamine metabolite DOPAC and dopamine reveals ratios that are 50 to 200% higher in grafted striata compared to normal, suggesting that the grafted neurons have an increased transmitter turnover}},
  author       = {{Brundin, Patrik and Emgård, Mia and Mundt-Petersen, Ulrika and Emgård, Mia}},
  booktitle    = {{CNS regeneration: Basic Science and Clinical Applications}},
  isbn         = {{9780127050706}},
  keywords     = {{graft survival; Basic science; Intracerebral grafts; Huntington's disease cell therapy; Parkinson's disease cell therapy}},
  language     = {{eng}},
  month        = {{06}},
  pages        = {{299--299}},
  publisher    = {{Academic Press}},
  title        = {{Grafts of Embryonic Dopamine Neurons in Rodent Models of Parkinson's Disease}},
  url          = {{https://www.sciencedirect.com/science/article/pii/B9780127050706500123}},
  year         = {{1999}},
}