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Differentiation of the Gastric Mucosa I. Role of histamine in control of function and integrity of oxyntic mucosa: understanding gastric physiology through disruption of targeted genes

Chen, Duan; Aihara, Takeshi; Zhao, Chun-Mei; Håkanson, Rolf LU and Okabe, Susumu (2006) In American Journal of Physiology: Gastrointestinal and Liver Physiology 291(4). p.539-544
Abstract
Many physiological functions of the stomach depend on an intact mucosal integrity; function reflects structure and vice versa. Histamine in the stomach is synthesized by histidine decarboxylase (HDC), stored in enterochromaffin-like (ECL) cells, and released in response to gastrin, acting on CCK2 receptors on the ECL cells. Mobilized ECL cell histamine stimulates histamine H-2 receptors on the parietal cells, resulting in acid secretion. The parietal cells express H-2, M-3, and CCK2 receptors and somatostatin sst(2) receptors. This review discusses the consequences of disrupting genes that are important for ECL cell histamine release and synthesis (HDC, gastrin, and CCK2 receptor genes) and genes that are important for "cross-talk" between... (More)
Many physiological functions of the stomach depend on an intact mucosal integrity; function reflects structure and vice versa. Histamine in the stomach is synthesized by histidine decarboxylase (HDC), stored in enterochromaffin-like (ECL) cells, and released in response to gastrin, acting on CCK2 receptors on the ECL cells. Mobilized ECL cell histamine stimulates histamine H-2 receptors on the parietal cells, resulting in acid secretion. The parietal cells express H-2, M-3, and CCK2 receptors and somatostatin sst(2) receptors. This review discusses the consequences of disrupting genes that are important for ECL cell histamine release and synthesis (HDC, gastrin, and CCK2 receptor genes) and genes that are important for "cross-talk" between H-2 receptors and other receptors on the parietal cell (CCK2, M-3, and sst(2) receptors). Such analysis may provide insight into the functional significance of gastric histamine. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
gastric acid secretion, knockout mice, oxyntic mucosal proliferation, gastrin, and differentiation, gastrin receptor, histamine
in
American Journal of Physiology: Gastrointestinal and Liver Physiology
volume
291
issue
4
pages
539 - 544
publisher
American Physiological Society
external identifiers
  • pmid:16959953
  • wos:000240364400001
  • scopus:33749449884
ISSN
1522-1547
DOI
10.1152/ajpgi.00178.2006
language
English
LU publication?
yes
id
09c596f1-9b9f-4b84-b162-051007a60aa0 (old id 394293)
date added to LUP
2007-10-01 17:45:34
date last changed
2019-02-20 04:49:34
@article{09c596f1-9b9f-4b84-b162-051007a60aa0,
  abstract     = {Many physiological functions of the stomach depend on an intact mucosal integrity; function reflects structure and vice versa. Histamine in the stomach is synthesized by histidine decarboxylase (HDC), stored in enterochromaffin-like (ECL) cells, and released in response to gastrin, acting on CCK2 receptors on the ECL cells. Mobilized ECL cell histamine stimulates histamine H-2 receptors on the parietal cells, resulting in acid secretion. The parietal cells express H-2, M-3, and CCK2 receptors and somatostatin sst(2) receptors. This review discusses the consequences of disrupting genes that are important for ECL cell histamine release and synthesis (HDC, gastrin, and CCK2 receptor genes) and genes that are important for "cross-talk" between H-2 receptors and other receptors on the parietal cell (CCK2, M-3, and sst(2) receptors). Such analysis may provide insight into the functional significance of gastric histamine.},
  author       = {Chen, Duan and Aihara, Takeshi and Zhao, Chun-Mei and Håkanson, Rolf and Okabe, Susumu},
  issn         = {1522-1547},
  keyword      = {gastric acid secretion,knockout mice,oxyntic mucosal proliferation,gastrin,and differentiation,gastrin receptor,histamine},
  language     = {eng},
  number       = {4},
  pages        = {539--544},
  publisher    = {American Physiological Society},
  series       = {American Journal of Physiology: Gastrointestinal and Liver Physiology},
  title        = {Differentiation of the Gastric Mucosa I. Role of histamine in control of function and integrity of oxyntic mucosa: understanding gastric physiology through disruption of targeted genes},
  url          = {http://dx.doi.org/10.1152/ajpgi.00178.2006},
  volume       = {291},
  year         = {2006},
}