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The beta(1)-selective Adrenoceptor Agonist Dobutamine'': A Fallacy Being Perpetuated

Waldeck, Bertil LU (2011) 21st International Symposium on Chirality 23(1). p.63-64
Abstract
Dobutamine is a cardiotonic agent, developed as a racemate more than 30 years ago. The compound soon got the label "the beta 1-selective adrenoceptor agonist''. However, a closer examination of the enantiomers showed that (+)-dobutamine is predominantly a beta(1)- and beta(2)-adrenoceptor agonist with modest selectivity whereas (-)-dobutamine is predominantly an alpha(1)-adrenoceptor agonist. Nevertheless, rac dobutamine is still frequently used as a tool for classification of beta-adrenoceptors. This ignorance of chiralilty may lead to erroneous conclusions and consolidate false labels. Chirality 23: 63-64, 2011. (C) 2010 Wiley-Liss, Inc.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
beta-adrenoceptors, alpha-adrenoceptors, dobutamine, enantiomers, selectivity
host publication
Chirality
volume
23
issue
1
pages
63 - 64
publisher
John Wiley & Sons Inc.
conference name
21st International Symposium on Chirality
conference dates
2009-07-12 - 2009-07-15
external identifiers
  • wos:000285262400007
  • scopus:78650026307
  • pmid:21125687
ISSN
1520-636X
0899-0042
DOI
10.1002/chir.20874
language
English
LU publication?
yes
id
09dc56db-05d3-41bb-8f1e-9d44c17b8393 (old id 1774007)
date added to LUP
2016-04-01 10:46:00
date last changed
2025-04-04 15:24:54
@inproceedings{09dc56db-05d3-41bb-8f1e-9d44c17b8393,
  abstract     = {{Dobutamine is a cardiotonic agent, developed as a racemate more than 30 years ago. The compound soon got the label "the beta 1-selective adrenoceptor agonist''. However, a closer examination of the enantiomers showed that (+)-dobutamine is predominantly a beta(1)- and beta(2)-adrenoceptor agonist with modest selectivity whereas (-)-dobutamine is predominantly an alpha(1)-adrenoceptor agonist. Nevertheless, rac dobutamine is still frequently used as a tool for classification of beta-adrenoceptors. This ignorance of chiralilty may lead to erroneous conclusions and consolidate false labels. Chirality 23: 63-64, 2011. (C) 2010 Wiley-Liss, Inc.}},
  author       = {{Waldeck, Bertil}},
  booktitle    = {{Chirality}},
  issn         = {{1520-636X}},
  keywords     = {{beta-adrenoceptors; alpha-adrenoceptors; dobutamine; enantiomers; selectivity}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{63--64}},
  publisher    = {{John Wiley & Sons Inc.}},
  title        = {{The beta(1)-selective Adrenoceptor Agonist Dobutamine'': A Fallacy Being Perpetuated}},
  url          = {{http://dx.doi.org/10.1002/chir.20874}},
  doi          = {{10.1002/chir.20874}},
  volume       = {{23}},
  year         = {{2011}},
}