The beta(1)-selective Adrenoceptor Agonist Dobutamine'': A Fallacy Being Perpetuated
(2011) 21st International Symposium on Chirality 23(1). p.63-64- Abstract
- Dobutamine is a cardiotonic agent, developed as a racemate more than 30 years ago. The compound soon got the label "the beta 1-selective adrenoceptor agonist''. However, a closer examination of the enantiomers showed that (+)-dobutamine is predominantly a beta(1)- and beta(2)-adrenoceptor agonist with modest selectivity whereas (-)-dobutamine is predominantly an alpha(1)-adrenoceptor agonist. Nevertheless, rac dobutamine is still frequently used as a tool for classification of beta-adrenoceptors. This ignorance of chiralilty may lead to erroneous conclusions and consolidate false labels. Chirality 23: 63-64, 2011. (C) 2010 Wiley-Liss, Inc.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1774007
- author
- Waldeck, Bertil LU
- organization
- publishing date
- 2011
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- beta-adrenoceptors, alpha-adrenoceptors, dobutamine, enantiomers, selectivity
- host publication
- Chirality
- volume
- 23
- issue
- 1
- pages
- 63 - 64
- publisher
- John Wiley and Sons
- conference name
- 21st International Symposium on Chirality
- conference dates
- 2009-07-12 - 2009-07-15
- external identifiers
-
- wos:000285262400007
- scopus:78650026307
- pmid:21125687
- ISSN
- 1520-636X
- 0899-0042
- DOI
- 10.1002/chir.20874
- language
- English
- LU publication?
- yes
- id
- 09dc56db-05d3-41bb-8f1e-9d44c17b8393 (old id 1774007)
- date added to LUP
- 2016-04-01 10:46:00
- date last changed
- 2021-02-17 07:22:15
@inproceedings{09dc56db-05d3-41bb-8f1e-9d44c17b8393, abstract = {Dobutamine is a cardiotonic agent, developed as a racemate more than 30 years ago. The compound soon got the label "the beta 1-selective adrenoceptor agonist''. However, a closer examination of the enantiomers showed that (+)-dobutamine is predominantly a beta(1)- and beta(2)-adrenoceptor agonist with modest selectivity whereas (-)-dobutamine is predominantly an alpha(1)-adrenoceptor agonist. Nevertheless, rac dobutamine is still frequently used as a tool for classification of beta-adrenoceptors. This ignorance of chiralilty may lead to erroneous conclusions and consolidate false labels. Chirality 23: 63-64, 2011. (C) 2010 Wiley-Liss, Inc.}, author = {Waldeck, Bertil}, booktitle = {Chirality}, issn = {1520-636X}, language = {eng}, number = {1}, pages = {63--64}, publisher = {John Wiley and Sons}, title = {The beta(1)-selective Adrenoceptor Agonist Dobutamine'': A Fallacy Being Perpetuated}, url = {http://dx.doi.org/10.1002/chir.20874}, doi = {10.1002/chir.20874}, volume = {23}, year = {2011}, }