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Nobiletin improves emotional and novelty recognition memory but not spatial referential memory

Kang, Jiyun ; Shin, Jung-Won ; Kim, Yoo-Rim ; Swanberg, Kelley M LU orcid ; Kim, Yooseung ; Bae, Jae Ryong ; Kim, Young Ki ; Lee, Jinwon ; Kim, Soo-Yeon and Sohn, Nak-Won , et al. (2017) In Journal of Natural Medicines 71(1). p.181-189
Abstract

How to maintain and enhance cognitive functions for both aged and young populations is a highly interesting subject. But candidate memory-enhancing reagents are tested almost exclusively on lesioned or aged animals. Also, there is insufficient information on the type of memory these reagents can improve. Working memory, located in the prefrontal cortex, manages short-term sensory information, but, by gaining significant relevance, this information is converted to long-term memory by hippocampal formation and/or amygdala, followed by tagging with space-time or emotional cues, respectively. Nobiletin is a product of citrus peel known for cognitive-enhancing effects in various pharmacological and neurodegenerative disease models, yet, it... (More)

How to maintain and enhance cognitive functions for both aged and young populations is a highly interesting subject. But candidate memory-enhancing reagents are tested almost exclusively on lesioned or aged animals. Also, there is insufficient information on the type of memory these reagents can improve. Working memory, located in the prefrontal cortex, manages short-term sensory information, but, by gaining significant relevance, this information is converted to long-term memory by hippocampal formation and/or amygdala, followed by tagging with space-time or emotional cues, respectively. Nobiletin is a product of citrus peel known for cognitive-enhancing effects in various pharmacological and neurodegenerative disease models, yet, it is not well studied in non-lesioned animals and the type of memory that nobiletin can improve remains unclear. In this study, 8-week-old male mice were tested using behavioral measurements for working, spatial referential, emotional and visual recognition memory after daily administration of nobiletin. While nobiletin did not induce any change of spontaneous activity in the open field test, freezing by fear conditioning and novel object recognition increased. However, the effectiveness of spatial navigation in the Y-maze and Morris water maze was not improved. These results mean that nobiletin can specifically improve memories of emotionally salient information associated with fear and novelty, but not of spatial information without emotional saliency. Accordingly, the use of nobiletin on normal subjects as a memory enhancer would be more effective on emotional types but may have limited value for the improvement of episodic memories.

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publishing date
type
Contribution to journal
publication status
published
keywords
Animals, Emotions, Flavones/administration & dosage, Male, Memory Disorders/drug therapy, Memory, Short-Term/drug effects, Mice
in
Journal of Natural Medicines
volume
71
issue
1
pages
181 - 189
publisher
Springer
external identifiers
  • scopus:84994403982
  • pmid:27830412
ISSN
1340-3443
DOI
10.1007/s11418-016-1047-4
language
English
LU publication?
no
id
09f0341a-d2c3-412a-93a0-d23d4240e157
date added to LUP
2023-09-18 15:02:59
date last changed
2024-04-19 00:56:46
@article{09f0341a-d2c3-412a-93a0-d23d4240e157,
  abstract     = {{<p>How to maintain and enhance cognitive functions for both aged and young populations is a highly interesting subject. But candidate memory-enhancing reagents are tested almost exclusively on lesioned or aged animals. Also, there is insufficient information on the type of memory these reagents can improve. Working memory, located in the prefrontal cortex, manages short-term sensory information, but, by gaining significant relevance, this information is converted to long-term memory by hippocampal formation and/or amygdala, followed by tagging with space-time or emotional cues, respectively. Nobiletin is a product of citrus peel known for cognitive-enhancing effects in various pharmacological and neurodegenerative disease models, yet, it is not well studied in non-lesioned animals and the type of memory that nobiletin can improve remains unclear. In this study, 8-week-old male mice were tested using behavioral measurements for working, spatial referential, emotional and visual recognition memory after daily administration of nobiletin. While nobiletin did not induce any change of spontaneous activity in the open field test, freezing by fear conditioning and novel object recognition increased. However, the effectiveness of spatial navigation in the Y-maze and Morris water maze was not improved. These results mean that nobiletin can specifically improve memories of emotionally salient information associated with fear and novelty, but not of spatial information without emotional saliency. Accordingly, the use of nobiletin on normal subjects as a memory enhancer would be more effective on emotional types but may have limited value for the improvement of episodic memories.</p>}},
  author       = {{Kang, Jiyun and Shin, Jung-Won and Kim, Yoo-Rim and Swanberg, Kelley M and Kim, Yooseung and Bae, Jae Ryong and Kim, Young Ki and Lee, Jinwon and Kim, Soo-Yeon and Sohn, Nak-Won and Maeng, Sungho}},
  issn         = {{1340-3443}},
  keywords     = {{Animals; Emotions; Flavones/administration & dosage; Male; Memory Disorders/drug therapy; Memory, Short-Term/drug effects; Mice}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{181--189}},
  publisher    = {{Springer}},
  series       = {{Journal of Natural Medicines}},
  title        = {{Nobiletin improves emotional and novelty recognition memory but not spatial referential memory}},
  url          = {{http://dx.doi.org/10.1007/s11418-016-1047-4}},
  doi          = {{10.1007/s11418-016-1047-4}},
  volume       = {{71}},
  year         = {{2017}},
}