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Seasonal influenza vaccine effectiveness against laboratory-confirmed influenza in 2015-2016 : A hospital-based test-negative case-control study in Lithuania

Kuliese, Monika ; Jancoriene, Ligita ; Grimalauskaite, Rita ; Zablockiene, Birute ; Damuleviciene, Gyte ; Velyvyte, Daiva ; Lesauskaite, Vita ; Ambrozaitis, Arvydas ; Mickiene, Aukse and Gefenaite, Giedre LU (2017) In BMJ Open 7(10).
Abstract

Objective A case-control study was conducted to assess seasonal influenza vaccine effectiveness (SIVE) during the 2015-2016 influenza season. Methods A study was performed in three departments in Lithuania between 1 December 2015 and 1 May 2016. Data on demographic and clinical characteristics including influenza vaccination status were collected from the patients recommended to receive the seasonal influenza vaccine. Influenza virus infection was confirmed by multiplex reverse transcription polymerase chain reaction (RT-PCR). Results Ninety-one (56.4%) of the 163 included subjects were ≥65 years old. Fifteen (9.2%) subjects were vaccinated against influenza at least 2 weeks before the onset of influenza symptoms, 12 of them were ≥65... (More)

Objective A case-control study was conducted to assess seasonal influenza vaccine effectiveness (SIVE) during the 2015-2016 influenza season. Methods A study was performed in three departments in Lithuania between 1 December 2015 and 1 May 2016. Data on demographic and clinical characteristics including influenza vaccination status were collected from the patients recommended to receive the seasonal influenza vaccine. Influenza virus infection was confirmed by multiplex reverse transcription polymerase chain reaction (RT-PCR). Results Ninety-one (56.4%) of the 163 included subjects were ≥65 years old. Fifteen (9.2%) subjects were vaccinated against influenza at least 2 weeks before the onset of influenza symptoms, 12 of them were ≥65 years old. Of the 72 (44.2%) influenza virus positive cases, 65 (39.9%) were confirmed with influenza A (including 50 cases of influenza A(H1N1)pdm09), eight (4.9%) were confirmed with influenza B and one was a co-infection. Unadjusted SIVE against any influenza, influenza type A and influenza A(H1N1)pdm09 was 57% (95% CI -41% to 87%), 52% (95% CI -57% to 85%) and 70% (95% CI -43% to 94%) respectively. Conclusion Although SIVE estimates were not statistically significant the point estimates suggest moderate effectiveness against influenza type A.

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author
; ; ; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
effectiveness, influenza, influenza vaccination, Lithuania, test-negative case-control study
in
BMJ Open
volume
7
issue
10
article number
e017835
publisher
British Medical Journal Publishing Group
external identifiers
  • pmid:29018073
  • scopus:85031297159
ISSN
2044-6055
DOI
10.1136/bmjopen-2017-017835
language
English
LU publication?
no
id
0a066f18-5112-4502-a281-84dda29b1b1f
date added to LUP
2020-05-14 14:16:26
date last changed
2020-11-03 01:38:30
@article{0a066f18-5112-4502-a281-84dda29b1b1f,
  abstract     = {<p>Objective A case-control study was conducted to assess seasonal influenza vaccine effectiveness (SIVE) during the 2015-2016 influenza season. Methods A study was performed in three departments in Lithuania between 1 December 2015 and 1 May 2016. Data on demographic and clinical characteristics including influenza vaccination status were collected from the patients recommended to receive the seasonal influenza vaccine. Influenza virus infection was confirmed by multiplex reverse transcription polymerase chain reaction (RT-PCR). Results Ninety-one (56.4%) of the 163 included subjects were ≥65 years old. Fifteen (9.2%) subjects were vaccinated against influenza at least 2 weeks before the onset of influenza symptoms, 12 of them were ≥65 years old. Of the 72 (44.2%) influenza virus positive cases, 65 (39.9%) were confirmed with influenza A (including 50 cases of influenza A(H1N1)pdm09), eight (4.9%) were confirmed with influenza B and one was a co-infection. Unadjusted SIVE against any influenza, influenza type A and influenza A(H1N1)pdm09 was 57% (95% CI -41% to 87%), 52% (95% CI -57% to 85%) and 70% (95% CI -43% to 94%) respectively. Conclusion Although SIVE estimates were not statistically significant the point estimates suggest moderate effectiveness against influenza type A.</p>},
  author       = {Kuliese, Monika and Jancoriene, Ligita and Grimalauskaite, Rita and Zablockiene, Birute and Damuleviciene, Gyte and Velyvyte, Daiva and Lesauskaite, Vita and Ambrozaitis, Arvydas and Mickiene, Aukse and Gefenaite, Giedre},
  issn         = {2044-6055},
  language     = {eng},
  month        = {10},
  number       = {10},
  publisher    = {British Medical Journal Publishing Group},
  series       = {BMJ Open},
  title        = {Seasonal influenza vaccine effectiveness against laboratory-confirmed influenza in 2015-2016 : A hospital-based test-negative case-control study in Lithuania},
  url          = {http://dx.doi.org/10.1136/bmjopen-2017-017835},
  doi          = {10.1136/bmjopen-2017-017835},
  volume       = {7},
  year         = {2017},
}