Advanced

Evolutionary adaptation to environmental stressors : A common response at the proteomic level

Sørensen, Jesper G.; Schou, Mads F. LU and Loeschcke, Volker (2017) In Evolution 71(6). p.1627-1642
Abstract
Mechanistic trade-offs between traits under selection can shape and constrain evolutionary adaptation to environmental stressors. However, our knowledge of the quantitative and qualitative overlap in the molecular machinery among stress tolerance traits is highly restricted by the challenges of comparing and interpreting data between separate studies and laboratories, as well as to extrapolating between different levels of biological organization. We investigated the expression of the constitutive proteome (833 proteins) of 35 Drosophila melanogaster replicate populations artificially selected for increased resistance to six different environmental stressors. The evolved proteomes were significantly differentiated from replicated control... (More)
Mechanistic trade-offs between traits under selection can shape and constrain evolutionary adaptation to environmental stressors. However, our knowledge of the quantitative and qualitative overlap in the molecular machinery among stress tolerance traits is highly restricted by the challenges of comparing and interpreting data between separate studies and laboratories, as well as to extrapolating between different levels of biological organization. We investigated the expression of the constitutive proteome (833 proteins) of 35 Drosophila melanogaster replicate populations artificially selected for increased resistance to six different environmental stressors. The evolved proteomes were significantly differentiated from replicated control lines. A targeted analysis of the constitutive proteomes revealed a regime-specific selection response among heat-shock proteins, which provides evidence that selection also adjusts the constitutive expression of these molecular chaperones. Although the selection response in some proteins was regime specific, the results were dominated by evidence for a “common stress response.” With the exception of high temperature survival, we found no evidence for negative correlations between environmental stress resistance traits, meaning that evolutionary adaptation is not constrained by mechanistic trade-offs in regulation of functional important proteins. Instead, standing genetic variation and genetic trade-offs outside regulatory domains likely constrain the evolutionary responses in natural populations.
(Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Drosophila melanogaster,Ectotherms,General stress response,Heat-shock protein,Stress tolerance,Thermal stress
in
Evolution
volume
71
issue
6
pages
1627 - 1642
publisher
Wiley-Blackwell
external identifiers
  • scopus:85018632863
ISSN
1558-5646
DOI
10.1111/evo.13243
language
English
LU publication?
no
id
0a0cf0f8-228e-4e2d-bacd-8534f6cc3f44
date added to LUP
2017-12-18 09:47:26
date last changed
2018-04-22 04:34:15
@article{0a0cf0f8-228e-4e2d-bacd-8534f6cc3f44,
  abstract     = {Mechanistic trade-offs between traits under selection can shape and constrain evolutionary adaptation to environmental stressors. However, our knowledge of the quantitative and qualitative overlap in the molecular machinery among stress tolerance traits is highly restricted by the challenges of comparing and interpreting data between separate studies and laboratories, as well as to extrapolating between different levels of biological organization. We investigated the expression of the constitutive proteome (833 proteins) of 35 Drosophila melanogaster replicate populations artificially selected for increased resistance to six different environmental stressors. The evolved proteomes were significantly differentiated from replicated control lines. A targeted analysis of the constitutive proteomes revealed a regime-specific selection response among heat-shock proteins, which provides evidence that selection also adjusts the constitutive expression of these molecular chaperones. Although the selection response in some proteins was regime specific, the results were dominated by evidence for a “common stress response.” With the exception of high temperature survival, we found no evidence for negative correlations between environmental stress resistance traits, meaning that evolutionary adaptation is not constrained by mechanistic trade-offs in regulation of functional important proteins. Instead, standing genetic variation and genetic trade-offs outside regulatory domains likely constrain the evolutionary responses in natural populations.<br/>},
  author       = {Sørensen, Jesper G. and Schou, Mads F. and Loeschcke, Volker},
  issn         = {1558-5646},
  keyword      = {Drosophila melanogaster,Ectotherms,General stress response,Heat-shock protein,Stress tolerance,Thermal stress},
  language     = {eng},
  number       = {6},
  pages        = {1627--1642},
  publisher    = {Wiley-Blackwell},
  series       = {Evolution},
  title        = {Evolutionary adaptation to environmental stressors : A common response at the proteomic level},
  url          = {http://dx.doi.org/10.1111/evo.13243},
  volume       = {71},
  year         = {2017},
}