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No association between infections, HLA type and other transplant-related factors and risk of cutaneous squamous cell carcinoma in solid organ transplant recipients

Ingvar, Åsa LU orcid ; Ekström Smedby, Karin ; Lindelöf, Bernt ; Fernberg, Pia ; Bellocco, Rino ; Tufveson, Gunnar ; Höglund, Petter and Adami, Johanna (2012) In Acta Dermato-Venereologica 92(6). p.14-609
Abstract

Recipients of solid organ transplants are at a markedly increased risk of cutaneous squamous cell carcinoma (SCC). We investigated potential associations between post-transplant infections, HLA type, and other transplant-related factors and risk of SCC, taking immuno-suppressive treatment into account. A population-based case-control study was conducted. All patients who developed SCC during follow-up (1970-1997) were eligible as cases (n = 207). Controls (n = 189) were individually matched to the cases on age and calendar period of transplantation. Detailed exposure information was collected through an extensive, blinded review of medical records. Odds ratios were computed with conditional logistic regression. There were no significant... (More)

Recipients of solid organ transplants are at a markedly increased risk of cutaneous squamous cell carcinoma (SCC). We investigated potential associations between post-transplant infections, HLA type, and other transplant-related factors and risk of SCC, taking immuno-suppressive treatment into account. A population-based case-control study was conducted. All patients who developed SCC during follow-up (1970-1997) were eligible as cases (n = 207). Controls (n = 189) were individually matched to the cases on age and calendar period of transplantation. Detailed exposure information was collected through an extensive, blinded review of medical records. Odds ratios were computed with conditional logistic regression. There were no significant associations with any infectious agents, or with number and timing of infections, specific HLA-type, donor characteristics, or other transplant characteristics and risk of post-transplant SCC. These results suggest that risk of post-transplant SCC is neither closely related to specific post-transplant infectious disorders, nor to the infectious load or specific HLA types.

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author
; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adolescent, Adult, Carcinoma, Squamous Cell/etiology, Case-Control Studies, Child, Child, Preschool, Communicable Diseases/etiology, Female, HLA Antigens/immunology, Histocompatibility, Humans, Immunosuppressive Agents/adverse effects, Infant, Infant, Newborn, Logistic Models, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Organ Transplantation/adverse effects, Risk Assessment, Risk Factors, Skin Neoplasms/etiology, Sweden, Time Factors, Treatment Outcome, Young Adult
in
Acta Dermato-Venereologica
volume
92
issue
6
pages
6 pages
publisher
Medical Journals Limited
external identifiers
  • scopus:84867757564
  • pmid:22293782
ISSN
1651-2057
DOI
10.2340/00015555-1271
language
English
LU publication?
no
id
0a15c6a0-8c88-401a-bca7-aa161cbe464c
date added to LUP
2020-11-16 09:43:55
date last changed
2024-01-02 21:48:58
@article{0a15c6a0-8c88-401a-bca7-aa161cbe464c,
  abstract     = {{<p>Recipients of solid organ transplants are at a markedly increased risk of cutaneous squamous cell carcinoma (SCC). We investigated potential associations between post-transplant infections, HLA type, and other transplant-related factors and risk of SCC, taking immuno-suppressive treatment into account. A population-based case-control study was conducted. All patients who developed SCC during follow-up (1970-1997) were eligible as cases (n = 207). Controls (n = 189) were individually matched to the cases on age and calendar period of transplantation. Detailed exposure information was collected through an extensive, blinded review of medical records. Odds ratios were computed with conditional logistic regression. There were no significant associations with any infectious agents, or with number and timing of infections, specific HLA-type, donor characteristics, or other transplant characteristics and risk of post-transplant SCC. These results suggest that risk of post-transplant SCC is neither closely related to specific post-transplant infectious disorders, nor to the infectious load or specific HLA types.</p>}},
  author       = {{Ingvar, Åsa and Ekström Smedby, Karin and Lindelöf, Bernt and Fernberg, Pia and Bellocco, Rino and Tufveson, Gunnar and Höglund, Petter and Adami, Johanna}},
  issn         = {{1651-2057}},
  keywords     = {{Adolescent; Adult; Carcinoma, Squamous Cell/etiology; Case-Control Studies; Child; Child, Preschool; Communicable Diseases/etiology; Female; HLA Antigens/immunology; Histocompatibility; Humans; Immunosuppressive Agents/adverse effects; Infant; Infant, Newborn; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Organ Transplantation/adverse effects; Risk Assessment; Risk Factors; Skin Neoplasms/etiology; Sweden; Time Factors; Treatment Outcome; Young Adult}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{14--609}},
  publisher    = {{Medical Journals Limited}},
  series       = {{Acta Dermato-Venereologica}},
  title        = {{No association between infections, HLA type and other transplant-related factors and risk of cutaneous squamous cell carcinoma in solid organ transplant recipients}},
  url          = {{http://dx.doi.org/10.2340/00015555-1271}},
  doi          = {{10.2340/00015555-1271}},
  volume       = {{92}},
  year         = {{2012}},
}