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Therapeutic Potential of C1-Inhibitor in Vascular Diseases and Beyond

Sundler Björkman, Linda LU orcid ; Eswaran, Harish and Grover, Steven P (2025) In Arteriosclerosis, Thrombosis, and Vascular Biology
Abstract

C1INH (C1-inhibitor) is a multifunctional SERPIN (serine protease inhibitor) that functions as a major negative regulator of the complement, coagulation, and kallikrein-kinin systems. C1INH products were originally developed for the treatment of hereditary angioedema associated with C1INH deficiency. A growing body of literature indicates that C1INH products may find utility in the management of several other disease states. In this review, we detail the key biological activities of C1INH and consider the pathophysiological role of C1INH targets in many conditions. The therapeutic potential of exogenous C1INH is highlighted in the settings of thromboembolism, ischemia-reperfusion injury, sepsis, transplantation, and coronavirus disease... (More)

C1INH (C1-inhibitor) is a multifunctional SERPIN (serine protease inhibitor) that functions as a major negative regulator of the complement, coagulation, and kallikrein-kinin systems. C1INH products were originally developed for the treatment of hereditary angioedema associated with C1INH deficiency. A growing body of literature indicates that C1INH products may find utility in the management of several other disease states. In this review, we detail the key biological activities of C1INH and consider the pathophysiological role of C1INH targets in many conditions. The therapeutic potential of exogenous C1INH is highlighted in the settings of thromboembolism, ischemia-reperfusion injury, sepsis, transplantation, and coronavirus disease 2019.

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Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
epub
subject
in
Arteriosclerosis, Thrombosis, and Vascular Biology
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:41410053
ISSN
1524-4636
DOI
10.1161/ATVBAHA.125.323743
language
English
LU publication?
yes
id
0a497c2e-fc62-4e81-9eb5-a7c8763cb0e4
date added to LUP
2025-12-19 08:50:01
date last changed
2025-12-19 08:50:01
@article{0a497c2e-fc62-4e81-9eb5-a7c8763cb0e4,
  abstract     = {{<p>C1INH (C1-inhibitor) is a multifunctional SERPIN (serine protease inhibitor) that functions as a major negative regulator of the complement, coagulation, and kallikrein-kinin systems. C1INH products were originally developed for the treatment of hereditary angioedema associated with C1INH deficiency. A growing body of literature indicates that C1INH products may find utility in the management of several other disease states. In this review, we detail the key biological activities of C1INH and consider the pathophysiological role of C1INH targets in many conditions. The therapeutic potential of exogenous C1INH is highlighted in the settings of thromboembolism, ischemia-reperfusion injury, sepsis, transplantation, and coronavirus disease 2019.</p>}},
  author       = {{Sundler Björkman, Linda and Eswaran, Harish and Grover, Steven P}},
  issn         = {{1524-4636}},
  language     = {{eng}},
  month        = {{12}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Arteriosclerosis, Thrombosis, and Vascular Biology}},
  title        = {{Therapeutic Potential of C1-Inhibitor in Vascular Diseases and Beyond}},
  url          = {{http://dx.doi.org/10.1161/ATVBAHA.125.323743}},
  doi          = {{10.1161/ATVBAHA.125.323743}},
  year         = {{2025}},
}