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The Association Between Psychiatric Disorders and Telomere Length : A Meta-Analysis Involving 14,827 Persons

Darrow, Sabrina M.; Verhoeven, Josine E.; Révész, Dóra; Lindqvist, Daniel LU ; Penninx, Brenda W J H; Delucchi, Kevin L.; Wolkowitz, Owen M. and Mathews, Carol A. (2016) In Psychosomatic Medicine 78(7). p.776-787
Abstract

OBJECTIVE: This study examined the relationship between leukocyte telomere length (LTL), a marker of cell aging, and psychiatric disorders in adults compared with controls using meta-analytic methods. METHODS: Data were abstracted from studies examining the relationship between LTL and adult psychiatric disorders. In addition to an overall estimate of effect size, subgroup analyses and meta-regression were performed to examine whether covariates (including psychiatric diagnoses) moderated the estimate. RESULTS: A significant overall effect size showing LTL shortening was found across all psychiatric disorders (Hedge g = −0.50, p <.001). Subgroup analyses did not demonstrate significant differences in effect size based on individual... (More)

OBJECTIVE: This study examined the relationship between leukocyte telomere length (LTL), a marker of cell aging, and psychiatric disorders in adults compared with controls using meta-analytic methods. METHODS: Data were abstracted from studies examining the relationship between LTL and adult psychiatric disorders. In addition to an overall estimate of effect size, subgroup analyses and meta-regression were performed to examine whether covariates (including psychiatric diagnoses) moderated the estimate. RESULTS: A significant overall effect size showing LTL shortening was found across all psychiatric disorders (Hedge g = −0.50, p <.001). Subgroup analyses did not demonstrate significant differences in effect size based on individual covariates (psychiatric disorder, sex, age, or assay method). The meta-regression indicated that although type of disorder and, likely, age moderate the overall effect size, the heterogeneity between studies could not be explained by a model that included these variables as well as sex and assay method. Although not significantly different, posttraumatic stress disorder, anxiety disorders, and depressive disorders had comparatively larger effect sizes (−1.27, −0.53, and −0.55), and psychotic and bipolar disorders had comparatively smaller ones (−0.23 and −0.26). CONCLUSIONS: We observed a robust effect size of LTL shortening for psychiatric disorders as a whole compared with controls. The results were less straightforward regarding relative differences in the strength of this association by specific disorder. Future studies should focus on mechanisms explaining accelerated cell aging with psychiatric illness, defining directions (if any) of causality and elucidating possible differences in this association between disorders.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Psychosomatic Medicine
volume
78
issue
7
pages
776 - 787
publisher
Lippincott Williams and Wilkins
external identifiers
  • scopus:84976523467
  • wos:000383999400002
ISSN
0033-3174
DOI
10.1097/PSY.0000000000000356
language
English
LU publication?
yes
id
0a6b0684-4667-45a9-8e11-d9d640c1a09b
date added to LUP
2016-07-21 11:03:24
date last changed
2017-10-22 05:17:45
@article{0a6b0684-4667-45a9-8e11-d9d640c1a09b,
  abstract     = {<p>OBJECTIVE: This study examined the relationship between leukocyte telomere length (LTL), a marker of cell aging, and psychiatric disorders in adults compared with controls using meta-analytic methods. METHODS: Data were abstracted from studies examining the relationship between LTL and adult psychiatric disorders. In addition to an overall estimate of effect size, subgroup analyses and meta-regression were performed to examine whether covariates (including psychiatric diagnoses) moderated the estimate. RESULTS: A significant overall effect size showing LTL shortening was found across all psychiatric disorders (Hedge g = −0.50, p &lt;.001). Subgroup analyses did not demonstrate significant differences in effect size based on individual covariates (psychiatric disorder, sex, age, or assay method). The meta-regression indicated that although type of disorder and, likely, age moderate the overall effect size, the heterogeneity between studies could not be explained by a model that included these variables as well as sex and assay method. Although not significantly different, posttraumatic stress disorder, anxiety disorders, and depressive disorders had comparatively larger effect sizes (−1.27, −0.53, and −0.55), and psychotic and bipolar disorders had comparatively smaller ones (−0.23 and −0.26). CONCLUSIONS: We observed a robust effect size of LTL shortening for psychiatric disorders as a whole compared with controls. The results were less straightforward regarding relative differences in the strength of this association by specific disorder. Future studies should focus on mechanisms explaining accelerated cell aging with psychiatric illness, defining directions (if any) of causality and elucidating possible differences in this association between disorders.</p>},
  author       = {Darrow, Sabrina M. and Verhoeven, Josine E. and Révész, Dóra and Lindqvist, Daniel and Penninx, Brenda W J H and Delucchi, Kevin L. and Wolkowitz, Owen M. and Mathews, Carol A.},
  issn         = {0033-3174},
  language     = {eng},
  month        = {09},
  number       = {7},
  pages        = {776--787},
  publisher    = {Lippincott Williams and Wilkins},
  series       = {Psychosomatic Medicine},
  title        = {The Association Between Psychiatric Disorders and Telomere Length : A Meta-Analysis Involving 14,827 Persons},
  url          = {http://dx.doi.org/10.1097/PSY.0000000000000356},
  volume       = {78},
  year         = {2016},
}