Vitamin K1 Administration Increases the Level of Circulating Carboxylated Osteocalcin in Critically Ill Patients
Aydin, Nadide ; Kander, Thomas LU
; Schott, Ulf
LU
and Hafizi, Sassan
(2025)
In Nutrients
17(2).
p.1-13
- Abstract
- Background/Objectives: Vitamin K-dependent proteins (VKDPs) all commonly possess specially modified γ-carboxyglutamic acid residues created in a vitamin K-dependent manner. Several liver-derived coagulation factors are well characterised VKDPs. However, much less is known about extrahepatic VKDPs, which are more diverse in their molecular structures and functions, and some of which have been implicated in inflammatory disorders. Vitamin K metabolism was shown to be impaired in critically ill patients, in whom systemic inflammation and sepsis are common features. Therefore, the aim of this study was to investigate the effect of vitamin K administration to these patients on their circulating levels of selected VKDPs. A particular novelty of... (More)
- Background/Objectives: Vitamin K-dependent proteins (VKDPs) all commonly possess specially modified γ-carboxyglutamic acid residues created in a vitamin K-dependent manner. Several liver-derived coagulation factors are well characterised VKDPs. However, much less is known about extrahepatic VKDPs, which are more diverse in their molecular structures and functions, and some of which have been implicated in inflammatory disorders. Vitamin K metabolism was shown to be impaired in critically ill patients, in whom systemic inflammation and sepsis are common features. Therefore, the aim of this study was to investigate the effect of vitamin K administration to these patients on their circulating levels of selected VKDPs. A particular novelty of this study was the measurement of specifically carboxylated forms of these proteins in addition to their overall levels. Methods: Blood samples were taken from 47 patients in the intensive care unit before and approximately 24 h after intravenous vitamin K1 (10 mg) administration, and proteins were analysed by specific immunoassay. Results: Vitamin K1 induced increases in plasma levels of carboxylated osteocalcin and total Gas6 (p = 0.0002 and p = 0.0032, respectively). No changes were detected in levels of carboxylated Gas6 or PIVKA-II (undercarboxylated prothrombin), although the latter positively correlated with undercarboxylated osteocalcin (r = 0.38). Conclusion: Injected vitamin K1 increases the blood levels of two distinct VKDPs in critically ill patients, both of which have been implicated in inflammation regulation, including the increased carboxylation of one of them. (Less)
- Abstract (Swedish)
- Abstract: Background/Objectives: Vitamin K-dependent proteins (VKDPs) all commonly
possess specially modified γ-carboxyglutamic acid residues created in a vitamin
K-dependent manner. Several liver-derived coagulation factors are well characterised
VKDPs. However, much less is known about extrahepatic VKDPs, which are more diverse
in their molecular structures and functions, and some of which have been implicated in
inflammatory disorders. Vitamin K metabolism was shown to be impaired in critically ill
patients, in whom systemic inflammation and sepsis are common features. Therefore, the
aim of this study was to investigate the effect of vitamin K administration to these patients
on their circulating levels... (More) - Abstract: Background/Objectives: Vitamin K-dependent proteins (VKDPs) all commonly
possess specially modified γ-carboxyglutamic acid residues created in a vitamin
K-dependent manner. Several liver-derived coagulation factors are well characterised
VKDPs. However, much less is known about extrahepatic VKDPs, which are more diverse
in their molecular structures and functions, and some of which have been implicated in
inflammatory disorders. Vitamin K metabolism was shown to be impaired in critically ill
patients, in whom systemic inflammation and sepsis are common features. Therefore, the
aim of this study was to investigate the effect of vitamin K administration to these patients
on their circulating levels of selected VKDPs. A particular novelty of this study was the
measurement of specifically carboxylated forms of these proteins in addition to their overall
levels. Methods: Blood samples were taken from 47 patients in the intensive care unit before
and approximately 24 h after intravenous vitamin K1 (10 mg) administration, and proteins
were analysed by specific immunoassay. Results: Vitamin K1 induced increases in plasma
levels of carboxylated osteocalcin and total Gas6 (p = 0.0002 and p = 0.0032, respectively).
No changes were detected in levels of carboxylated Gas6 or PIVKA-II (undercarboxylated
prothrombin), although the latter positively correlated with undercarboxylated osteocalcin
(r = 0.38). Conclusion: Injected vitamin K1 increases the blood levels of two distinct VKDPs
in critically ill patients, both of which have been implicated in inflammation regulation,
including the increased carboxylation of one of them. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/0a73329b-9c8f-49c9-a65c-247df1b049b9
- author
- Aydin, Nadide
; Kander, Thomas
LU
; Schott, Ulf
LU
and Hafizi, Sassan
- organization
- publishing date
- 2025-01-19
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- vitamin K, osteocalcin, Gas6, PIVKA-II, Carboxylation, intensive care, inflammation, Sepsis, Acute lung injury, Leukocyte recruitment, Intravital fluorescence microscopy
- in
- Nutrients
- volume
- 17
- issue
- 2
- article number
- 348
- pages
- 13 pages
- publisher
- MDPI AG
- external identifiers
-
- scopus:85215806835
- pmid:39861478
- ISSN
- 2072-6643
- DOI
- 10.3390/nu17020348
- language
- English
- LU publication?
- yes
- id
- 0a73329b-9c8f-49c9-a65c-247df1b049b9
- date added to LUP
- 2025-01-22 08:41:05
- date last changed
- 2025-04-24 03:00:11
@article{0a73329b-9c8f-49c9-a65c-247df1b049b9,
abstract = {{Background/Objectives: Vitamin K-dependent proteins (VKDPs) all commonly possess specially modified γ-carboxyglutamic acid residues created in a vitamin K-dependent manner. Several liver-derived coagulation factors are well characterised VKDPs. However, much less is known about extrahepatic VKDPs, which are more diverse in their molecular structures and functions, and some of which have been implicated in inflammatory disorders. Vitamin K metabolism was shown to be impaired in critically ill patients, in whom systemic inflammation and sepsis are common features. Therefore, the aim of this study was to investigate the effect of vitamin K administration to these patients on their circulating levels of selected VKDPs. A particular novelty of this study was the measurement of specifically carboxylated forms of these proteins in addition to their overall levels. Methods: Blood samples were taken from 47 patients in the intensive care unit before and approximately 24 h after intravenous vitamin K1 (10 mg) administration, and proteins were analysed by specific immunoassay. Results: Vitamin K1 induced increases in plasma levels of carboxylated osteocalcin and total Gas6 (p = 0.0002 and p = 0.0032, respectively). No changes were detected in levels of carboxylated Gas6 or PIVKA-II (undercarboxylated prothrombin), although the latter positively correlated with undercarboxylated osteocalcin (r = 0.38). Conclusion: Injected vitamin K1 increases the blood levels of two distinct VKDPs in critically ill patients, both of which have been implicated in inflammation regulation, including the increased carboxylation of one of them.}},
author = {{Aydin, Nadide and Kander, Thomas and Schott, Ulf and Hafizi, Sassan}},
issn = {{2072-6643}},
keywords = {{vitamin K; osteocalcin; Gas6; PIVKA-II; Carboxylation; intensive care; inflammation; Sepsis, Acute lung injury, Leukocyte recruitment, Intravital fluorescence microscopy}},
language = {{eng}},
month = {{01}},
number = {{2}},
pages = {{1--13}},
publisher = {{MDPI AG}},
series = {{Nutrients}},
title = {{Vitamin K1 Administration Increases the Level of Circulating Carboxylated Osteocalcin in Critically Ill Patients}},
url = {{https://lup.lub.lu.se/search/files/206657165/nutrients-17-00348_1_.pdf}},
doi = {{10.3390/nu17020348}},
volume = {{17}},
year = {{2025}},
}