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Chapter 14 Proteomics and remodeling of extracellular matrix in lung diseases

Malmström, Johan LU (2005) In Comprehensive Analytical Chemistry 46. p.535-556
Abstract
This chapter summarizes the proteomic tools and strategies used in asthma research. It provides a background to the remodeling process occurring in the lung—in diseases such as asthma and chronic obstructive pulmonary disease (COPD)—as well as a description of the status of the current proteomics techniques. It also describes strategies for the discovery of disease markers that can be used to monitor disease progression/reversibility and strategies for finding molecular features behind the disease. Asthma and COPD are examples of diseases characterized by both inflammation and tissue remodeling. Proteomics is the analysis of the protein complement arising from the genome. Essentially, proteomics requires protein separation and protein... (More)
This chapter summarizes the proteomic tools and strategies used in asthma research. It provides a background to the remodeling process occurring in the lung—in diseases such as asthma and chronic obstructive pulmonary disease (COPD)—as well as a description of the status of the current proteomics techniques. It also describes strategies for the discovery of disease markers that can be used to monitor disease progression/reversibility and strategies for finding molecular features behind the disease. Asthma and COPD are examples of diseases characterized by both inflammation and tissue remodeling. Proteomics is the analysis of the protein complement arising from the genome. Essentially, proteomics requires protein separation and protein identification and in many cases protein quantification. The cornerstones in proteomics are protein/peptide separation by gel electrophoresis and/or chromatography and protein identification by mass spectrometry (MS). Rapid development in different fields—such as separation sciences, MS, and computer-aided software tools—has allowed increasingly difficult tasks being addressed regarding the molecular aspects of the remodeling observed in asthma and COPD. Current state-of-the-art technologies allow the identification, quantification, and classification of thousands of components in a limited time frame. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Proteomics and Peptidomics : New Technology Platforms Elucidating Biology - New Technology Platforms Elucidating Biology
series title
Comprehensive Analytical Chemistry
editor
Marko-Varga, V.
volume
46
pages
22 pages
external identifiers
  • scopus:66249131638
ISSN
0166-526X
ISBN
9780444518101
DOI
10.1016/S0166-526X(05)46014-6
language
English
LU publication?
yes
id
0a8faa46-cbaa-4c8e-a903-aaaf01e8abb5
date added to LUP
2018-12-10 08:34:53
date last changed
2020-01-13 01:16:09
@inbook{0a8faa46-cbaa-4c8e-a903-aaaf01e8abb5,
  abstract     = {This chapter summarizes the proteomic tools and strategies used in asthma research. It provides a background to the remodeling process occurring in the lung—in diseases such as asthma and chronic obstructive pulmonary disease (COPD)—as well as a description of the status of the current proteomics techniques. It also describes strategies for the discovery of disease markers that can be used to monitor disease progression/reversibility and strategies for finding molecular features behind the disease. Asthma and COPD are examples of diseases characterized by both inflammation and tissue remodeling. Proteomics is the analysis of the protein complement arising from the genome. Essentially, proteomics requires protein separation and protein identification and in many cases protein quantification. The cornerstones in proteomics are protein/peptide separation by gel electrophoresis and/or chromatography and protein identification by mass spectrometry (MS). Rapid development in different fields—such as separation sciences, MS, and computer-aided software tools—has allowed increasingly difficult tasks being addressed regarding the molecular aspects of the remodeling observed in asthma and COPD. Current state-of-the-art technologies allow the identification, quantification, and classification of thousands of components in a limited time frame.},
  author       = {Malmström, Johan},
  booktitle    = {Proteomics and Peptidomics : New Technology Platforms Elucidating Biology},
  editor       = {Marko-Varga, V.},
  isbn         = {9780444518101},
  issn         = {0166-526X},
  language     = {eng},
  month        = {12},
  pages        = {535--556},
  series       = {Comprehensive Analytical Chemistry},
  title        = {Chapter 14 Proteomics and remodeling of extracellular matrix in lung diseases},
  url          = {http://dx.doi.org/10.1016/S0166-526X(05)46014-6},
  doi          = {10.1016/S0166-526X(05)46014-6},
  volume       = {46},
  year         = {2005},
}