Blood lipids in 75,048 type 2 diabetic patients: a population-based survey from the Swedish National diabetes register
(2011) In European Journal of Cardiovascular Prevention & Rehabilitation 18(1). p.97-105- Abstract
- Background: Type 2 diabetes and diabetic dyslipidemia are high-risk conditions for cardiovascular disease. However, the description of the distribution of blood lipids in diabetic patients has not been based on population-based surveys. The aim of this study was to describe diabetic dyslipidemia in a large unselected sample of patients from the Swedish National Diabetes Register. Methods: Blood lipid profiles and clinical characteristics in 75,048 type 2 diabetic patients (57% men) were studied. Results: Pronounced hypertriglyceridemia (triglycerides >4.0mmol/l) was seen in 3.4% of the patients. Total cholesterol (TC), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C) and non-HDL-C were generally higher, and LDL-C/HDL-C and... (More)
- Background: Type 2 diabetes and diabetic dyslipidemia are high-risk conditions for cardiovascular disease. However, the description of the distribution of blood lipids in diabetic patients has not been based on population-based surveys. The aim of this study was to describe diabetic dyslipidemia in a large unselected sample of patients from the Swedish National Diabetes Register. Methods: Blood lipid profiles and clinical characteristics in 75,048 type 2 diabetic patients (57% men) were studied. Results: Pronounced hypertriglyceridemia (triglycerides >4.0mmol/l) was seen in 3.4% of the patients. Total cholesterol (TC), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C) and non-HDL-C were generally higher, and LDL-C/HDL-C and Non-HDL-C/HDL-C ratios were lower in women. Mean TC, LDL-C as well as HDL-C values were lower in patients treated with lipid-lowering agents, whereas triglycerides was higher than in the untreated patients. In patients not treated with lipid-lowering agents all blood lipids increased in women and decreased in men (except HDL-C) at higher ages. Patients with LDL-C/HDL-C ratio >= 3 were slightly younger, less frequently used lipid-lowering drugs and had not so often a history of coronary heart disease or stroke. Conclusion: The distribution of blood lipids in this large sample of unselected type 2 diabetic patients challenges the previous conception of diabetic dyslipidemia, and calls for new studies to explain the roles of LDL-C and HDL-C as strong cardiovascular risk factors in type 2 diabetes. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1876170
- author
- Eriksson, Mats ; Zethelius, Bjorn ; Eeg-Olofsson, Katarina ; Nilsson, Peter LU ; Gudbjornsdottir, Soffia ; Cederholm, Jan and Eliasson, Bjorn
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Blood lipids, cholesterol, epidemiology, high-density, lipoprotein-cholesterol, low-density lipoprotein-cholesterol, triglycerides, type 2 diabetes
- in
- European Journal of Cardiovascular Prevention & Rehabilitation
- volume
- 18
- issue
- 1
- pages
- 97 - 105
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000287780400011
- scopus:79955707469
- ISSN
- 1741-8275
- DOI
- 10.1097/HJR.0b013e32833ba61e
- language
- English
- LU publication?
- yes
- id
- 0a99d9a8-c8b0-47c4-94ed-516c5d9834a7 (old id 1876170)
- date added to LUP
- 2016-04-01 09:51:09
- date last changed
- 2022-04-19 20:13:48
@article{0a99d9a8-c8b0-47c4-94ed-516c5d9834a7,
abstract = {{Background: Type 2 diabetes and diabetic dyslipidemia are high-risk conditions for cardiovascular disease. However, the description of the distribution of blood lipids in diabetic patients has not been based on population-based surveys. The aim of this study was to describe diabetic dyslipidemia in a large unselected sample of patients from the Swedish National Diabetes Register. Methods: Blood lipid profiles and clinical characteristics in 75,048 type 2 diabetic patients (57% men) were studied. Results: Pronounced hypertriglyceridemia (triglycerides >4.0mmol/l) was seen in 3.4% of the patients. Total cholesterol (TC), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C) and non-HDL-C were generally higher, and LDL-C/HDL-C and Non-HDL-C/HDL-C ratios were lower in women. Mean TC, LDL-C as well as HDL-C values were lower in patients treated with lipid-lowering agents, whereas triglycerides was higher than in the untreated patients. In patients not treated with lipid-lowering agents all blood lipids increased in women and decreased in men (except HDL-C) at higher ages. Patients with LDL-C/HDL-C ratio >= 3 were slightly younger, less frequently used lipid-lowering drugs and had not so often a history of coronary heart disease or stroke. Conclusion: The distribution of blood lipids in this large sample of unselected type 2 diabetic patients challenges the previous conception of diabetic dyslipidemia, and calls for new studies to explain the roles of LDL-C and HDL-C as strong cardiovascular risk factors in type 2 diabetes.}},
author = {{Eriksson, Mats and Zethelius, Bjorn and Eeg-Olofsson, Katarina and Nilsson, Peter and Gudbjornsdottir, Soffia and Cederholm, Jan and Eliasson, Bjorn}},
issn = {{1741-8275}},
keywords = {{Blood lipids; cholesterol; epidemiology; high-density; lipoprotein-cholesterol; low-density lipoprotein-cholesterol; triglycerides; type 2 diabetes}},
language = {{eng}},
number = {{1}},
pages = {{97--105}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{European Journal of Cardiovascular Prevention & Rehabilitation}},
title = {{Blood lipids in 75,048 type 2 diabetic patients: a population-based survey from the Swedish National diabetes register}},
url = {{http://dx.doi.org/10.1097/HJR.0b013e32833ba61e}},
doi = {{10.1097/HJR.0b013e32833ba61e}},
volume = {{18}},
year = {{2011}},
}