Proportions of polyunsaturated fatty acids in umbilical cord blood at birth are related to atopic eczema development in the first year of life
Barman, Malin ; Stråvik, Mia ; Broberg, Karin LU
; Sandin, Anna
; Wold, Agnes E.
and Sandberg, Ann Sofie
(2021)
In Nutrients
13(11).
- Abstract
Atopic eczema, the most common atopic disease in infants, may pave the way for sensitization and allergy later in childhood. Fatty acids have immune-regulating properties and may regulate skin permeability. Here we examine whether the proportions of fatty acids among the infant and maternal plasma phospholipids at birth were associated with maternal dietary intake during pregnancy and development of atopic eczema during the first year of age in the Nutritional impact on Immunological maturation during Childhood in relation to the Environment (NICE) birth cohort. Dietary data were collected with a semi-quantitative food frequency questionnaire, fatty acids were measured with GC-MS and atopic eczema was diagnosed by a pediatric... (More)
Atopic eczema, the most common atopic disease in infants, may pave the way for sensitization and allergy later in childhood. Fatty acids have immune-regulating properties and may regulate skin permeability. Here we examine whether the proportions of fatty acids among the infant and maternal plasma phospholipids at birth were associated with maternal dietary intake during pregnancy and development of atopic eczema during the first year of age in the Nutritional impact on Immunological maturation during Childhood in relation to the Environment (NICE) birth cohort. Dietary data were collected with a semi-quantitative food frequency questionnaire, fatty acids were measured with GC-MS and atopic eczema was diagnosed by a pediatric allergologist at 12 months of age. We found that higher proportions of n-6 PUFAs (including arachidonic acid) but lower proportions of n-3 PUFAs (including DPA) in the infant’s phospholipids at birth were associated with an increased risk of atopic eczema at 12 months of age. The n-6 and n-3 PUFAs were related to maternal intake of meat and fish, respectively. Our results suggest that prenatal exposure to unsaturated fatty acids is associated with eczema development in the infant. Maternal diet during pregnancy may partly explain the fatty acid profiles in utero.
(Less)
- author
- Barman, Malin
; Stråvik, Mia
; Broberg, Karin
LU
; Sandin, Anna
; Wold, Agnes E.
and Sandberg, Ann Sofie
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Arachidonic acid, Atopic eczema, Cord blood, Diet, Fatty acids, N-3 PUFAs, N-6 PUFAs, NICE birth cohort, Phospholipids, Pregnancy
- in
- Nutrients
- volume
- 13
- issue
- 11
- article number
- 3779
- publisher
- MDPI AG
- external identifiers
-
- pmid:34836034
- scopus:85117569095
- ISSN
- 2072-6643
- DOI
- 10.3390/nu13113779
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
- id
- 0aba919c-ebca-4846-a484-7954b64585a6
- date added to LUP
- 2021-11-19 14:34:25
- date last changed
- 2025-03-24 00:24:06
@article{0aba919c-ebca-4846-a484-7954b64585a6,
abstract = {{<p>Atopic eczema, the most common atopic disease in infants, may pave the way for sensitization and allergy later in childhood. Fatty acids have immune-regulating properties and may regulate skin permeability. Here we examine whether the proportions of fatty acids among the infant and maternal plasma phospholipids at birth were associated with maternal dietary intake during pregnancy and development of atopic eczema during the first year of age in the Nutritional impact on Immunological maturation during Childhood in relation to the Environment (NICE) birth cohort. Dietary data were collected with a semi-quantitative food frequency questionnaire, fatty acids were measured with GC-MS and atopic eczema was diagnosed by a pediatric allergologist at 12 months of age. We found that higher proportions of n-6 PUFAs (including arachidonic acid) but lower proportions of n-3 PUFAs (including DPA) in the infant’s phospholipids at birth were associated with an increased risk of atopic eczema at 12 months of age. The n-6 and n-3 PUFAs were related to maternal intake of meat and fish, respectively. Our results suggest that prenatal exposure to unsaturated fatty acids is associated with eczema development in the infant. Maternal diet during pregnancy may partly explain the fatty acid profiles in utero.</p>}},
author = {{Barman, Malin and Stråvik, Mia and Broberg, Karin and Sandin, Anna and Wold, Agnes E. and Sandberg, Ann Sofie}},
issn = {{2072-6643}},
keywords = {{Arachidonic acid; Atopic eczema; Cord blood; Diet; Fatty acids; N-3 PUFAs; N-6 PUFAs; NICE birth cohort; Phospholipids; Pregnancy}},
language = {{eng}},
number = {{11}},
publisher = {{MDPI AG}},
series = {{Nutrients}},
title = {{Proportions of polyunsaturated fatty acids in umbilical cord blood at birth are related to atopic eczema development in the first year of life}},
url = {{http://dx.doi.org/10.3390/nu13113779}},
doi = {{10.3390/nu13113779}},
volume = {{13}},
year = {{2021}},
}