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Effect of latex-stimulated granulocytes on platelet aggregation in man

Zoucas, E. LU ; Faldt, R. LU and Ankerst, J. LU orcid (1985) In Haemostasis 15(3). p.176-181
Abstract

The effect of granulocytes on human platelet aggregation was investigated in vitro. Platelet function was assayed by photometric technique. Incubation of platelets with latex-stimulated granulocytes for 1 h at room temperature resulted in total inhibition of arachidonic acid-induced platelet aggregation. ADP-induced platelet aggregation was suppressed, lacked secondary wave and was pursued by swift disaggregation. Platelet aggregates induced by collagen dispersed faster under the influence of stimulated granulocytes. The present results indicate that granulocytes may play a role in the hemostatic mechanism in man.

Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Haemostasis
volume
15
issue
3
pages
176 - 181
publisher
Karger
external identifiers
  • scopus:0021868676
  • pmid:3928458
ISSN
0301-0147
DOI
10.1159/000215141
language
English
LU publication?
yes
id
0ac174ff-fabe-4583-863a-678d4e3f8f3d
date added to LUP
2021-01-15 15:34:22
date last changed
2024-01-03 04:42:35
@article{0ac174ff-fabe-4583-863a-678d4e3f8f3d,
  abstract     = {{<p>The effect of granulocytes on human platelet aggregation was investigated in vitro. Platelet function was assayed by photometric technique. Incubation of platelets with latex-stimulated granulocytes for 1 h at room temperature resulted in total inhibition of arachidonic acid-induced platelet aggregation. ADP-induced platelet aggregation was suppressed, lacked secondary wave and was pursued by swift disaggregation. Platelet aggregates induced by collagen dispersed faster under the influence of stimulated granulocytes. The present results indicate that granulocytes may play a role in the hemostatic mechanism in man.</p>}},
  author       = {{Zoucas, E. and Faldt, R. and Ankerst, J.}},
  issn         = {{0301-0147}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{176--181}},
  publisher    = {{Karger}},
  series       = {{Haemostasis}},
  title        = {{Effect of latex-stimulated granulocytes on platelet aggregation in man}},
  url          = {{http://dx.doi.org/10.1159/000215141}},
  doi          = {{10.1159/000215141}},
  volume       = {{15}},
  year         = {{1985}},
}