Exercise differentially affects metabolic functions and white adipose tissue in female letrozole- and dihydrotestosterone-induced mouse models of polycystic ovary syndrome
(2017) In Molecular and Cellular Endocrinology 448. p.66-78- Abstract
Here we hypothesized that exercise in dihydrotestosterone (DHT) or letrozole (LET)-induced polycystic ovary syndrome mouse models improves impaired insulin and glucose metabolism, adipose tissue morphology, and expression of genes related to adipogenesis, lipid metabolism, Notch pathway and browning in inguinal and mesenteric fat. DHT-exposed mice had increased body weight, increased number of large mesenteric adipocytes. LET-exposed mice displayed increased body weight and fat mass, decreased insulin sensitivity, increased frequency of small adipocytes and increased expression of genes related to lipolysis in mesenteric fat. In both models, exercise decreased fat mass and inguinal and mesenteric adipose tissue expression of Notch... (More)
Here we hypothesized that exercise in dihydrotestosterone (DHT) or letrozole (LET)-induced polycystic ovary syndrome mouse models improves impaired insulin and glucose metabolism, adipose tissue morphology, and expression of genes related to adipogenesis, lipid metabolism, Notch pathway and browning in inguinal and mesenteric fat. DHT-exposed mice had increased body weight, increased number of large mesenteric adipocytes. LET-exposed mice displayed increased body weight and fat mass, decreased insulin sensitivity, increased frequency of small adipocytes and increased expression of genes related to lipolysis in mesenteric fat. In both models, exercise decreased fat mass and inguinal and mesenteric adipose tissue expression of Notch pathway genes, and restored altered mesenteric adipocytes morphology. In conclusion, exercise restored mesenteric adipocytes morphology in DHT- and LET-exposed mice, and insulin sensitivity and mesenteric expression of lipolysis-related genes in LET-exposed mice. Benefits could be explained by downregulation of Notch, and modulation of browning and lipolysis pathways in the adipose tissue.
(Less)
- author
- organization
- publishing date
- 2017-03-24
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adipose tissue, Exercise, Polycystic ovary syndrome
- in
- Molecular and Cellular Endocrinology
- volume
- 448
- pages
- 66 - 78
- publisher
- Elsevier
- external identifiers
-
- pmid:28344042
- wos:000401218000007
- scopus:85016551867
- ISSN
- 0303-7207
- DOI
- 10.1016/j.mce.2017.03.025
- language
- English
- LU publication?
- yes
- id
- 0b073644-c4d7-40b1-b076-9d243eb6db10
- date added to LUP
- 2017-04-13 10:06:08
- date last changed
- 2024-09-15 23:35:39
@article{0b073644-c4d7-40b1-b076-9d243eb6db10, abstract = {{<p>Here we hypothesized that exercise in dihydrotestosterone (DHT) or letrozole (LET)-induced polycystic ovary syndrome mouse models improves impaired insulin and glucose metabolism, adipose tissue morphology, and expression of genes related to adipogenesis, lipid metabolism, Notch pathway and browning in inguinal and mesenteric fat. DHT-exposed mice had increased body weight, increased number of large mesenteric adipocytes. LET-exposed mice displayed increased body weight and fat mass, decreased insulin sensitivity, increased frequency of small adipocytes and increased expression of genes related to lipolysis in mesenteric fat. In both models, exercise decreased fat mass and inguinal and mesenteric adipose tissue expression of Notch pathway genes, and restored altered mesenteric adipocytes morphology. In conclusion, exercise restored mesenteric adipocytes morphology in DHT- and LET-exposed mice, and insulin sensitivity and mesenteric expression of lipolysis-related genes in LET-exposed mice. Benefits could be explained by downregulation of Notch, and modulation of browning and lipolysis pathways in the adipose tissue.</p>}}, author = {{Marcondes, Rodrigo R. and Maliqueo, Manuel and Fornes, Romina and Benrick, Anna and Hu, Min and Ivarsson, Niklas and Carlström, Mattias and Cushman, Samuel W. and Stenkula, Karin G. and Maciel, Gustavo A R and Stener-Victorin, Elisabet}}, issn = {{0303-7207}}, keywords = {{Adipose tissue; Exercise; Polycystic ovary syndrome}}, language = {{eng}}, month = {{03}}, pages = {{66--78}}, publisher = {{Elsevier}}, series = {{Molecular and Cellular Endocrinology}}, title = {{Exercise differentially affects metabolic functions and white adipose tissue in female letrozole- and dihydrotestosterone-induced mouse models of polycystic ovary syndrome}}, url = {{http://dx.doi.org/10.1016/j.mce.2017.03.025}}, doi = {{10.1016/j.mce.2017.03.025}}, volume = {{448}}, year = {{2017}}, }