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Evaluation of seismocardiography in detecting pre-load changes and cardiovascular disease : a comparative study with transthoracic echocardiography

Agam, Ahmad ; Agam, Ali ; Korsgaard, Emil ; Yding, Troels ; Kristensen, Charlotte Burup LU orcid ; Mogelvang, Rasmus ; Kragholm, Kristian ; Grønn Emerk, Kasper Janus ; Søgaard, Peter and Schmidt, Samuel Emil (2025) In European Heart Journal - Digital Health 6(4). p.811-821
Abstract

Aims This study aimed to test whether seismocardiography (SCG) can detect changes in loading conditions and detect significant differences in SCG signals between healthy individuals and those with cardiovascular disease (CVD). Methods Twenty-six subjects (age 45 ± 16 years and 77% male) were included, 11 healthy subjects and 15 subjects with CVD. SCG and results was compared with transthoracic echocardiography (TTE) before and after infusion of 2 L of isotonic saline. Nine subjects (34%) with CVD did not tolerate the full infusion (2 L infusion intolerant), while the remaining 17 subjects (2 L infusion tolerant) successfully completed the infusion. Significant changes in SCG measurements were observed after infusion, including... (More)

Aims This study aimed to test whether seismocardiography (SCG) can detect changes in loading conditions and detect significant differences in SCG signals between healthy individuals and those with cardiovascular disease (CVD). Methods Twenty-six subjects (age 45 ± 16 years and 77% male) were included, 11 healthy subjects and 15 subjects with CVD. SCG and results was compared with transthoracic echocardiography (TTE) before and after infusion of 2 L of isotonic saline. Nine subjects (34%) with CVD did not tolerate the full infusion (2 L infusion intolerant), while the remaining 17 subjects (2 L infusion tolerant) successfully completed the infusion. Significant changes in SCG measurements were observed after infusion, including amplitudes Ls (19%, P = 0.015), Dd (23%, P = 0.016), and Ed (48%, P < 0.001) as well as most time intervals. TTE measurements also showed post-infusion changes in stroke volume (15%, P = 0.038), mitral annular velocity (7%, P = 0.013), left ventricular ejection time (1%, P = 0.035), and global longitudinal strain (6%, P = 0.003). Although SCG did not detect differences between the healthy and CVD groups, the diastolic amplitude Cd-Dd significantly differed between the infusion tolerant and intolerant groups (pre-infusion: 7.7 vs. 3.7 mg, P = 0.046; post-infusion: 8.3 vs. 4.1 mg, P = 0.034). Conclusion SCG can detect changes in pre-load in both healthy subjects and subjects with CVD. SCG were also able to detect differences in SCG diastolic amplitudes between infusion-tolerant and -intolerant subjects, which may indicate ability to detect diastolic dysfunction and differences in left ventricular filling pressures.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Diastolic dysfunction, Echocardiography, Heart failure, Pre-load, Seismocardiography
in
European Heart Journal - Digital Health
volume
6
issue
4
pages
11 pages
publisher
Oxford University Press
external identifiers
  • scopus:105011380714
  • pmid:40703121
ISSN
2634-3916
DOI
10.1093/ehjdh/ztaf037
language
English
LU publication?
yes
additional info
Publisher Copyright: © The Author(s) 2025. Published by Oxford University Press on behalf of the European Society of Cardiology.
id
0b1b35f9-3a25-419e-8853-984e78c06223
date added to LUP
2025-12-15 14:48:08
date last changed
2025-12-16 03:47:54
@article{0b1b35f9-3a25-419e-8853-984e78c06223,
  abstract     = {{<p>Aims This study aimed to test whether seismocardiography (SCG) can detect changes in loading conditions and detect significant differences in SCG signals between healthy individuals and those with cardiovascular disease (CVD). Methods Twenty-six subjects (age 45 ± 16 years and 77% male) were included, 11 healthy subjects and 15 subjects with CVD. SCG and results was compared with transthoracic echocardiography (TTE) before and after infusion of 2 L of isotonic saline. Nine subjects (34%) with CVD did not tolerate the full infusion (2 L infusion intolerant), while the remaining 17 subjects (2 L infusion tolerant) successfully completed the infusion. Significant changes in SCG measurements were observed after infusion, including amplitudes Ls (19%, P = 0.015), Dd (23%, P = 0.016), and Ed (48%, P &lt; 0.001) as well as most time intervals. TTE measurements also showed post-infusion changes in stroke volume (15%, P = 0.038), mitral annular velocity (7%, P = 0.013), left ventricular ejection time (1%, P = 0.035), and global longitudinal strain (6%, P = 0.003). Although SCG did not detect differences between the healthy and CVD groups, the diastolic amplitude Cd-Dd significantly differed between the infusion tolerant and intolerant groups (pre-infusion: 7.7 vs. 3.7 mg, P = 0.046; post-infusion: 8.3 vs. 4.1 mg, P = 0.034). Conclusion SCG can detect changes in pre-load in both healthy subjects and subjects with CVD. SCG were also able to detect differences in SCG diastolic amplitudes between infusion-tolerant and -intolerant subjects, which may indicate ability to detect diastolic dysfunction and differences in left ventricular filling pressures.</p>}},
  author       = {{Agam, Ahmad and Agam, Ali and Korsgaard, Emil and Yding, Troels and Kristensen, Charlotte Burup and Mogelvang, Rasmus and Kragholm, Kristian and Grønn Emerk, Kasper Janus and Søgaard, Peter and Schmidt, Samuel Emil}},
  issn         = {{2634-3916}},
  keywords     = {{Diastolic dysfunction; Echocardiography; Heart failure; Pre-load; Seismocardiography}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{4}},
  pages        = {{811--821}},
  publisher    = {{Oxford University Press}},
  series       = {{European Heart Journal - Digital Health}},
  title        = {{Evaluation of seismocardiography in detecting pre-load changes and cardiovascular disease : a comparative study with transthoracic echocardiography}},
  url          = {{http://dx.doi.org/10.1093/ehjdh/ztaf037}},
  doi          = {{10.1093/ehjdh/ztaf037}},
  volume       = {{6}},
  year         = {{2025}},
}