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Longevity of anti-spike and anti-nucleocapsid antibodies after COVID-19 in solid organ transplant recipients compared to immunocompetent controls

Søfteland, John M. ; Gisslén, Magnus ; Liljeqvist, Jan Åke ; Friman, Vanda ; de Coursey, Emily ; Karason, Kristjan ; Ekelund, Jan ; Felldin, Marie ; Magnusson, Jesper and Baid-Agrawal, Seema , et al. (2022) In American Journal of Transplantation 22(4). p.1245-1252
Abstract

Solid organ transplant recipients (SOTRs) are on lifelong immunosuppression, which may interfere with adaptive immunity to COVID-19. The data on dynamics and duration of antibody response in SOTRs are limited. This longitudinal study examined the longevity of both anti-spike (S)- and anti-nucleocapsid (N)-specific IgG antibodies after COVID-19 in SOTRs compared to matched immunocompetent persons. SOTRs (n = 65) were matched with controls (n = 65) for COVID-19 disease severity, age, and sex in order of priority. Serum-IgG antibodies against N and S antigens of SARS-CoV-2 were analyzed. At 1 and 9 months after COVID-19, anti-S-IgG detectability decreased from 91% to 82% in SOTRs versus 100% to 95% in controls, whereas the anti-N-IgG... (More)

Solid organ transplant recipients (SOTRs) are on lifelong immunosuppression, which may interfere with adaptive immunity to COVID-19. The data on dynamics and duration of antibody response in SOTRs are limited. This longitudinal study examined the longevity of both anti-spike (S)- and anti-nucleocapsid (N)-specific IgG antibodies after COVID-19 in SOTRs compared to matched immunocompetent persons. SOTRs (n = 65) were matched with controls (n = 65) for COVID-19 disease severity, age, and sex in order of priority. Serum-IgG antibodies against N and S antigens of SARS-CoV-2 were analyzed. At 1 and 9 months after COVID-19, anti-S-IgG detectability decreased from 91% to 82% in SOTRs versus 100% to 95% in controls, whereas the anti-N-IgG decreased from 63% to 29% in SOTRs versus 89% to 46% in controls. A matched paired analysis showed SOTRs having significantly lower levels of anti-N-IgG at all time points (1 month p =.007, 3 months p <.001, 6 months p =.019, and 9 months p =.021) but not anti-S-IgG at any time points. A mixed-model analysis confirmed these findings except for anti-S-IgG at 1 month (p =.005) and identified severity score as the most important predictor of antibody response. SOTRs mount comparable S-specific, but not N-specific, antibody responses to SARS-CoV-2 infection compared to immunocompetent controls.

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publishing date
type
Contribution to journal
publication status
published
subject
keywords
antibody biology, clinical research/practice, immunosuppression/immune modulation, infection and infectious agents—viral, infectious disease, organ transplantation in general
in
American Journal of Transplantation
volume
22
issue
4
pages
1245 - 1252
publisher
Wiley-Blackwell
external identifiers
  • pmid:34860447
  • scopus:85121146042
ISSN
1600-6135
DOI
10.1111/ajt.16909
language
English
LU publication?
no
id
0b90b2db-d72a-44ef-9895-b8cbaffa51fa
date added to LUP
2022-01-31 15:16:13
date last changed
2024-04-06 17:28:55
@article{0b90b2db-d72a-44ef-9895-b8cbaffa51fa,
  abstract     = {{<p>Solid organ transplant recipients (SOTRs) are on lifelong immunosuppression, which may interfere with adaptive immunity to COVID-19. The data on dynamics and duration of antibody response in SOTRs are limited. This longitudinal study examined the longevity of both anti-spike (S)- and anti-nucleocapsid (N)-specific IgG antibodies after COVID-19 in SOTRs compared to matched immunocompetent persons. SOTRs (n = 65) were matched with controls (n = 65) for COVID-19 disease severity, age, and sex in order of priority. Serum-IgG antibodies against N and S antigens of SARS-CoV-2 were analyzed. At 1 and 9 months after COVID-19, anti-S-IgG detectability decreased from 91% to 82% in SOTRs versus 100% to 95% in controls, whereas the anti-N-IgG decreased from 63% to 29% in SOTRs versus 89% to 46% in controls. A matched paired analysis showed SOTRs having significantly lower levels of anti-N-IgG at all time points (1 month p =.007, 3 months p &lt;.001, 6 months p =.019, and 9 months p =.021) but not anti-S-IgG at any time points. A mixed-model analysis confirmed these findings except for anti-S-IgG at 1 month (p =.005) and identified severity score as the most important predictor of antibody response. SOTRs mount comparable S-specific, but not N-specific, antibody responses to SARS-CoV-2 infection compared to immunocompetent controls.</p>}},
  author       = {{Søfteland, John M. and Gisslén, Magnus and Liljeqvist, Jan Åke and Friman, Vanda and de Coursey, Emily and Karason, Kristjan and Ekelund, Jan and Felldin, Marie and Magnusson, Jesper and Baid-Agrawal, Seema and Wallquist, Carin and Schult, Andreas and Jacobsson, Hanna and Bergdahl, Anders and Bemark, Mats and Andersson, Lars Magnus and Holm Gunnarsson, Inger and Stenström, Jan and Leach, Susannah}},
  issn         = {{1600-6135}},
  keywords     = {{antibody biology; clinical research/practice; immunosuppression/immune modulation; infection and infectious agents—viral; infectious disease; organ transplantation in general}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{1245--1252}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{American Journal of Transplantation}},
  title        = {{Longevity of anti-spike and anti-nucleocapsid antibodies after COVID-19 in solid organ transplant recipients compared to immunocompetent controls}},
  url          = {{http://dx.doi.org/10.1111/ajt.16909}},
  doi          = {{10.1111/ajt.16909}},
  volume       = {{22}},
  year         = {{2022}},
}