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A biodegradable patch used as a pericardial substitute after cardiac surgery : 6- and 24-month evaluation with CT

Duvernoy, O ; Malm, T LU ; Ramström, J and Bowald, S (1995) In The Thoracic and Cardiovascular Surgeon 43(5). p.4-271
Abstract

Biodegradable patches made of polyhydroxybutyrate (PHB) were recently shown to limit postoperative pericardial adhesions when inserted into the pericardium in sheep. The present study was carried out to evaluate the presence of post-operative retrosternal adhesions after cardiac surgery in patients operated on with the PHB patch compared with those operated on without the insertion of such a patch. 50 patients admitted for CABG and/or valvular replacement were randomised to treatment either with pericardial closure with a patch or with the pericardium left open. In 39 of these (19 with and 20 without a PHB patch) computerised tomography was carried out six and twenty-four months postoperatively. Computerised tomography indicated a lower... (More)

Biodegradable patches made of polyhydroxybutyrate (PHB) were recently shown to limit postoperative pericardial adhesions when inserted into the pericardium in sheep. The present study was carried out to evaluate the presence of post-operative retrosternal adhesions after cardiac surgery in patients operated on with the PHB patch compared with those operated on without the insertion of such a patch. 50 patients admitted for CABG and/or valvular replacement were randomised to treatment either with pericardial closure with a patch or with the pericardium left open. In 39 of these (19 with and 20 without a PHB patch) computerised tomography was carried out six and twenty-four months postoperatively. Computerised tomography indicated a lower incidence (p < 0.05) of postoperative adhesions between the patch and the cardiac surface in the patch group, compared with the corresponding area in the non-patch group. A reduction of patch size in 27% (p = 0.003) was also seen.

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author
; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aged, Biodegradation, Environmental, Cardiac Surgical Procedures/methods, Female, Follow-Up Studies, Humans, Hydroxybutyrates, Incidence, Male, Membranes, Artificial, Middle Aged, Pericardium/diagnostic imaging, Polyesters, Tissue Adhesions, Tomography, X-Ray Computed
in
The Thoracic and Cardiovascular Surgeon
volume
43
issue
5
pages
4 pages
publisher
Georg Thieme Verlag
external identifiers
  • scopus:0028862088
  • pmid:8610286
ISSN
0171-6425
DOI
10.1055/s-2007-1013226
language
English
LU publication?
no
id
0ba16f5b-5a46-44e3-8a4d-42f848680f75
date added to LUP
2018-12-05 15:26:49
date last changed
2024-04-15 19:33:13
@article{0ba16f5b-5a46-44e3-8a4d-42f848680f75,
  abstract     = {{<p>Biodegradable patches made of polyhydroxybutyrate (PHB) were recently shown to limit postoperative pericardial adhesions when inserted into the pericardium in sheep. The present study was carried out to evaluate the presence of post-operative retrosternal adhesions after cardiac surgery in patients operated on with the PHB patch compared with those operated on without the insertion of such a patch. 50 patients admitted for CABG and/or valvular replacement were randomised to treatment either with pericardial closure with a patch or with the pericardium left open. In 39 of these (19 with and 20 without a PHB patch) computerised tomography was carried out six and twenty-four months postoperatively. Computerised tomography indicated a lower incidence (p &lt; 0.05) of postoperative adhesions between the patch and the cardiac surface in the patch group, compared with the corresponding area in the non-patch group. A reduction of patch size in 27% (p = 0.003) was also seen.</p>}},
  author       = {{Duvernoy, O and Malm, T and Ramström, J and Bowald, S}},
  issn         = {{0171-6425}},
  keywords     = {{Aged; Biodegradation, Environmental; Cardiac Surgical Procedures/methods; Female; Follow-Up Studies; Humans; Hydroxybutyrates; Incidence; Male; Membranes, Artificial; Middle Aged; Pericardium/diagnostic imaging; Polyesters; Tissue Adhesions; Tomography, X-Ray Computed}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{4--271}},
  publisher    = {{Georg Thieme Verlag}},
  series       = {{The Thoracic and Cardiovascular Surgeon}},
  title        = {{A biodegradable patch used as a pericardial substitute after cardiac surgery : 6- and 24-month evaluation with CT}},
  url          = {{http://dx.doi.org/10.1055/s-2007-1013226}},
  doi          = {{10.1055/s-2007-1013226}},
  volume       = {{43}},
  year         = {{1995}},
}