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Differential effect of hypothermia on the vascular tone and reactivity of the human coronary artery and graft vessels

Bodelsson, Mikael LU ; Arneklo-Nobin, B ; Chester, Alan LU ; Tadjkarimi, S ; Tornebrandt, K and Yacoub, M (1991) In Journal of Cardiovascular Surgery 32(3). p.288-294
Abstract
Hypothermia may contribute to vascular spasm during bypass surgery. The effect of cooling on the reactivity of the human coronary artery (CA), saphenous vein (SV) and internal mammary artery (IMA) was studied in vitro. In CA and IMA cooling diminished the resting tension and the contraction to potassium, noradrenaline and 5-hydroxytryptamine. In contrast, in SV the contraction to noradrenaline and 5-hydroxytryptamine was augmented by cooling. The effect of cold was reversible. These results demonstrate different effects of hypothermia in CA and the graft vessels. Thus, hypothermia augments the receptor-mediated contraction in SV but depresses it in IMA which thereby resembles CA. The difference is most marked in the contractile response to... (More)
Hypothermia may contribute to vascular spasm during bypass surgery. The effect of cooling on the reactivity of the human coronary artery (CA), saphenous vein (SV) and internal mammary artery (IMA) was studied in vitro. In CA and IMA cooling diminished the resting tension and the contraction to potassium, noradrenaline and 5-hydroxytryptamine. In contrast, in SV the contraction to noradrenaline and 5-hydroxytryptamine was augmented by cooling. The effect of cold was reversible. These results demonstrate different effects of hypothermia in CA and the graft vessels. Thus, hypothermia augments the receptor-mediated contraction in SV but depresses it in IMA which thereby resembles CA. The difference is most marked in the contractile response to 5-hydroxytryptamine, which may accumulate during surgery. This may contribute to spasm in the saphenous vein grafts and may be involved in the mechanisms responsible for the inferior patency of SV compared to IMA as a graft vessel. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Hypothermia, Induced : Muscle Contraction physiology : Muscle, Smooth, Vascular physiology
in
Journal of Cardiovascular Surgery
volume
32
issue
3
pages
288 - 294
publisher
Edizioni Minerva Medica
external identifiers
  • pmid:2055921
  • scopus:0025732850
ISSN
0021-9509
language
English
LU publication?
yes
id
0bb8314e-abe9-4476-9c94-981aaba91c3a (old id 1105728)
date added to LUP
2016-04-01 16:57:57
date last changed
2024-01-11 18:10:47
@article{0bb8314e-abe9-4476-9c94-981aaba91c3a,
  abstract     = {{Hypothermia may contribute to vascular spasm during bypass surgery. The effect of cooling on the reactivity of the human coronary artery (CA), saphenous vein (SV) and internal mammary artery (IMA) was studied in vitro. In CA and IMA cooling diminished the resting tension and the contraction to potassium, noradrenaline and 5-hydroxytryptamine. In contrast, in SV the contraction to noradrenaline and 5-hydroxytryptamine was augmented by cooling. The effect of cold was reversible. These results demonstrate different effects of hypothermia in CA and the graft vessels. Thus, hypothermia augments the receptor-mediated contraction in SV but depresses it in IMA which thereby resembles CA. The difference is most marked in the contractile response to 5-hydroxytryptamine, which may accumulate during surgery. This may contribute to spasm in the saphenous vein grafts and may be involved in the mechanisms responsible for the inferior patency of SV compared to IMA as a graft vessel.}},
  author       = {{Bodelsson, Mikael and Arneklo-Nobin, B and Chester, Alan and Tadjkarimi, S and Tornebrandt, K and Yacoub, M}},
  issn         = {{0021-9509}},
  keywords     = {{Hypothermia; Induced : Muscle Contraction physiology : Muscle; Smooth; Vascular physiology}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{288--294}},
  publisher    = {{Edizioni Minerva Medica}},
  series       = {{Journal of Cardiovascular Surgery}},
  title        = {{Differential effect of hypothermia on the vascular tone and reactivity of the human coronary artery and graft vessels}},
  volume       = {{32}},
  year         = {{1991}},
}