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Exposure to inorganic arsenic and gene expression in peripheral blood

Broberg, K. LU ; Ameer, S. S. LU ; Concha, Gabriela; Vahter, M and Engström, K. LU (2016) 6th International Congress on Arsenic in the Environment, AS 2016 In Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016 p.448-449
Abstract

Arsenic is an established carcinogen and a risk factor for several non-malignant diseases. Mechanisms of arsenic toxicity may include interference with gene expression. The impact of arsenic exposure on gene expression was evaluated in women (n = 80) living in the Puna of the northern Argentinian Andes with varying concentrations (10–1251 μg/L) of arsenic in drinking water. DirectHyb HumanHT-12 v4.0 was used for genome wide gene expression analysis. Robust linear regression model was used to each array to evaluate the relations between arsenic exposure, gene expression and with the influence of arsenic metabolism efficiency. Also, Ingenuity Pathway Analysis (IPA) was performed to look for relevant pathways, diseases, networks etc.... (More)

Arsenic is an established carcinogen and a risk factor for several non-malignant diseases. Mechanisms of arsenic toxicity may include interference with gene expression. The impact of arsenic exposure on gene expression was evaluated in women (n = 80) living in the Puna of the northern Argentinian Andes with varying concentrations (10–1251 μg/L) of arsenic in drinking water. DirectHyb HumanHT-12 v4.0 was used for genome wide gene expression analysis. Robust linear regression model was used to each array to evaluate the relations between arsenic exposure, gene expression and with the influence of arsenic metabolism efficiency. Also, Ingenuity Pathway Analysis (IPA) was performed to look for relevant pathways, diseases, networks etc. associated with the genes. In the association between arsenic and gene expression, most of the genes were downregu-lated. Pathway analyses revealed different expression pattern associated with arsenic exposure between women with high and low urinary %MMA, indicating variation in arsenic susceptibility by arsenic-methylation.

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publication status
published
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in
Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016
pages
2 pages
publisher
CRC Press/Balkema
conference name
6th International Congress on Arsenic in the Environment, AS 2016
external identifiers
  • scopus:85016991179
ISBN
9781138029415
language
English
LU publication?
yes
id
0bce8638-8e31-4d43-b642-3790e9a5a28c
date added to LUP
2017-05-11 11:55:02
date last changed
2017-05-11 11:55:02
@inproceedings{0bce8638-8e31-4d43-b642-3790e9a5a28c,
  abstract     = {<p>Arsenic is an established carcinogen and a risk factor for several non-malignant diseases. Mechanisms of arsenic toxicity may include interference with gene expression. The impact of arsenic exposure on gene expression was evaluated in women (n = 80) living in the Puna of the northern Argentinian Andes with varying concentrations (10–1251 μg/L) of arsenic in drinking water. DirectHyb HumanHT-12 v4.0 was used for genome wide gene expression analysis. Robust linear regression model was used to each array to evaluate the relations between arsenic exposure, gene expression and with the influence of arsenic metabolism efficiency. Also, Ingenuity Pathway Analysis (IPA) was performed to look for relevant pathways, diseases, networks etc. associated with the genes. In the association between arsenic and gene expression, most of the genes were downregu-lated. Pathway analyses revealed different expression pattern associated with arsenic exposure between women with high and low urinary %MMA, indicating variation in arsenic susceptibility by arsenic-methylation.</p>},
  author       = {Broberg, K. and Ameer, S. S. and Concha, Gabriela and Vahter, M and Engström, K.},
  booktitle    = {Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016},
  isbn         = {9781138029415},
  language     = {eng},
  pages        = {448--449},
  publisher    = {CRC Press/Balkema},
  title        = {Exposure to inorganic arsenic and gene expression in peripheral blood},
  year         = {2016},
}