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Exclusion of Disperse Orange 3 From the Textile Dye Mix Present in the Baseline Patch-Test Series : A Study by the International Contact Dermatitis Research Group

Isaksson, Marléne LU ; Antelmi, Annarita LU ; Stenton, Joanna ; Svedman, Cecilia LU ; Ale, Iris ; Andersen, Klaus Ejner ; Goh, Chee Leok ; Gonçalo, Margarida ; Hadzavdic, Suzana Ljubojevic and Matsunaga, Kayoko , et al. (2025) In Dermatitis 36(3). p.227-234
Abstract

Background: The textile dye mix (TDM) 6.6% in petrolatum contains Disperse Blue (DB) 35, Disperse Yellow 3, Disperse Orange (DO) 1 and 3, Disperse Red 1 and 17, and DB 106 and 124. The most frequent allergen in TDM-positive patients is DO 3. Around 85% of para-phenylenediamine (PPD)-allergic dermatitis patients have been positive to DO 3. There has been a discussion to exclude DO 3 from TDM 6.6% because of strong simultaneous reactions to TDM and PPD. Objective: To study if DO 3 can be excluded from TDM 6.6%. Methods: Patch tests were performed on 2951 dermatitis patients with TDM 6.6%, TDM 7.0% (without DO 3 but with the other disperse dyes at 1.0% each), DO 3 1.0%, and PPD 1.0% pet. Results: Contact allergy to TDM 6.6% was 4.3% and to... (More)

Background: The textile dye mix (TDM) 6.6% in petrolatum contains Disperse Blue (DB) 35, Disperse Yellow 3, Disperse Orange (DO) 1 and 3, Disperse Red 1 and 17, and DB 106 and 124. The most frequent allergen in TDM-positive patients is DO 3. Around 85% of para-phenylenediamine (PPD)-allergic dermatitis patients have been positive to DO 3. There has been a discussion to exclude DO 3 from TDM 6.6% because of strong simultaneous reactions to TDM and PPD. Objective: To study if DO 3 can be excluded from TDM 6.6%. Methods: Patch tests were performed on 2951 dermatitis patients with TDM 6.6%, TDM 7.0% (without DO 3 but with the other disperse dyes at 1.0% each), DO 3 1.0%, and PPD 1.0% pet. Results: Contact allergy to TDM 6.6% was 4.3% and to TDM 7.0% was 3.5%. Sixty-three out of 69 DO 3-positive patients were positive to PPD. The 102 patients positive to TDM 7.0% plus the 28 patients positive to PPD and TDM 6.6% but negative to TDM 7.0% were 130, outnumbering the 127 positive to TDM 6.6%. Conclusion: TDM 7.0% can replace TDM 6.6% in the International Contact Dermatitis Research Group baseline series, since TDM 7.0% together with PPD 1.0% will detect patients with textile dye allergy.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Dermatitis
volume
36
issue
3
pages
8 pages
publisher
Mary Ann Liebert, Inc.
external identifiers
  • scopus:105004916621
  • pmid:40332782
ISSN
1710-3568
DOI
10.1089/derm.2024.0036
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2025 American Contact Dermatitis Society. All Rights Reserved.
id
0bf53d5a-6c05-48cc-ab64-c0f6ad0eb7e4
date added to LUP
2025-08-11 15:10:01
date last changed
2025-08-12 04:13:36
@article{0bf53d5a-6c05-48cc-ab64-c0f6ad0eb7e4,
  abstract     = {{<p>Background: The textile dye mix (TDM) 6.6% in petrolatum contains Disperse Blue (DB) 35, Disperse Yellow 3, Disperse Orange (DO) 1 and 3, Disperse Red 1 and 17, and DB 106 and 124. The most frequent allergen in TDM-positive patients is DO 3. Around 85% of para-phenylenediamine (PPD)-allergic dermatitis patients have been positive to DO 3. There has been a discussion to exclude DO 3 from TDM 6.6% because of strong simultaneous reactions to TDM and PPD. Objective: To study if DO 3 can be excluded from TDM 6.6%. Methods: Patch tests were performed on 2951 dermatitis patients with TDM 6.6%, TDM 7.0% (without DO 3 but with the other disperse dyes at 1.0% each), DO 3 1.0%, and PPD 1.0% pet. Results: Contact allergy to TDM 6.6% was 4.3% and to TDM 7.0% was 3.5%. Sixty-three out of 69 DO 3-positive patients were positive to PPD. The 102 patients positive to TDM 7.0% plus the 28 patients positive to PPD and TDM 6.6% but negative to TDM 7.0% were 130, outnumbering the 127 positive to TDM 6.6%. Conclusion: TDM 7.0% can replace TDM 6.6% in the International Contact Dermatitis Research Group baseline series, since TDM 7.0% together with PPD 1.0% will detect patients with textile dye allergy.</p>}},
  author       = {{Isaksson, Marléne and Antelmi, Annarita and Stenton, Joanna and Svedman, Cecilia and Ale, Iris and Andersen, Klaus Ejner and Goh, Chee Leok and Gonçalo, Margarida and Hadzavdic, Suzana Ljubojevic and Matsunaga, Kayoko and Pratt, Melanie and Puangpet, Pailin and Schuttelaar, Marie Louise and Verma, Kaushal}},
  issn         = {{1710-3568}},
  language     = {{eng}},
  month        = {{05}},
  number       = {{3}},
  pages        = {{227--234}},
  publisher    = {{Mary Ann Liebert, Inc.}},
  series       = {{Dermatitis}},
  title        = {{Exclusion of Disperse Orange 3 From the Textile Dye Mix Present in the Baseline Patch-Test Series : A Study by the International Contact Dermatitis Research Group}},
  url          = {{http://dx.doi.org/10.1089/derm.2024.0036}},
  doi          = {{10.1089/derm.2024.0036}},
  volume       = {{36}},
  year         = {{2025}},
}