Can Parkinson's disease pathology be propagated from one neuron to another?
(2012) In Progress in Neurobiology 97. p.205-219- Abstract
- Parkinson's disease is the second most prevalent neurodegenerative disease, yet despite this, very little is known about the underlying cellular mechanisms. Initially it was thought to be a disease primarily involving loss of dopaminergic neurons in the substantia nigra pars compacta. Recent studies, however, have focused on observations that aggregated α-synuclein protein, the major component of Lewy bodies, is found throughout the nervous system. It is speculated that misfolded α-synuclein transfers between cells in a prion-like manner, thereby mediating the spread of the neuropathology. In this review, we discuss the staging (according to Braak) of Parkinson pathology and the concept describing the disease progression from one region of... (More)
- Parkinson's disease is the second most prevalent neurodegenerative disease, yet despite this, very little is known about the underlying cellular mechanisms. Initially it was thought to be a disease primarily involving loss of dopaminergic neurons in the substantia nigra pars compacta. Recent studies, however, have focused on observations that aggregated α-synuclein protein, the major component of Lewy bodies, is found throughout the nervous system. It is speculated that misfolded α-synuclein transfers between cells in a prion-like manner, thereby mediating the spread of the neuropathology. In this review, we discuss the staging (according to Braak) of Parkinson pathology and the concept describing the disease progression from one region of the brain to the other. We highlight how α-synuclein might be responsible for the spread of the disease. We compare the idea of a prion-like mechanism contributing to Parkinson's disease to emerging concepts that other proteins participate in similar processes in other neurodegenerative diseases. We then examine the future implications of a critical role in disease pathogenesis of α-synuclein for the classification, diagnosis and treatment of Parkinson's disease in the future. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2220348
- author
- Dunning, Christopher LU ; Reyes, Juan F LU ; Steiner, Jennifer LU and Brundin, Patrik LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Progress in Neurobiology
- volume
- 97
- pages
- 205 - 219
- publisher
- Elsevier
- external identifiers
-
- wos:000304796100011
- pmid:22115849
- scopus:84860686110
- pmid:22115849
- ISSN
- 1873-5118
- DOI
- 10.1016/j.pneurobio.2011.11.003
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041)
- id
- 0bfc1b76-1af6-4a69-b374-eb2e3861462b (old id 2220348)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22115849?dopt=Abstract
- date added to LUP
- 2016-04-01 10:34:47
- date last changed
- 2022-03-12 07:09:26
@article{0bfc1b76-1af6-4a69-b374-eb2e3861462b,
abstract = {{Parkinson's disease is the second most prevalent neurodegenerative disease, yet despite this, very little is known about the underlying cellular mechanisms. Initially it was thought to be a disease primarily involving loss of dopaminergic neurons in the substantia nigra pars compacta. Recent studies, however, have focused on observations that aggregated α-synuclein protein, the major component of Lewy bodies, is found throughout the nervous system. It is speculated that misfolded α-synuclein transfers between cells in a prion-like manner, thereby mediating the spread of the neuropathology. In this review, we discuss the staging (according to Braak) of Parkinson pathology and the concept describing the disease progression from one region of the brain to the other. We highlight how α-synuclein might be responsible for the spread of the disease. We compare the idea of a prion-like mechanism contributing to Parkinson's disease to emerging concepts that other proteins participate in similar processes in other neurodegenerative diseases. We then examine the future implications of a critical role in disease pathogenesis of α-synuclein for the classification, diagnosis and treatment of Parkinson's disease in the future.}},
author = {{Dunning, Christopher and Reyes, Juan F and Steiner, Jennifer and Brundin, Patrik}},
issn = {{1873-5118}},
language = {{eng}},
pages = {{205--219}},
publisher = {{Elsevier}},
series = {{Progress in Neurobiology}},
title = {{Can Parkinson's disease pathology be propagated from one neuron to another?}},
url = {{https://lup.lub.lu.se/search/files/1962759/2363521.pdf}},
doi = {{10.1016/j.pneurobio.2011.11.003}},
volume = {{97}},
year = {{2012}},
}