Intratumoral IL-7 delivery by mesenchymal stromal cells potentiates IFNgamma-transduced tumor cell immunotherapy of experimental glioma.
Gunnarsson, Salina LU ; Bexell, Daniel LU ; Svensson, Andreas LU ; Siesjö, Peter LU
; Darabi, Anna
LU
and Bengzon, Johan
LU
(2010)
In Journal of Neuroimmunology
218(1-2).
p.140-144
- Abstract
- The present study reports regression of pre-established experimental rat gliomas as a result of combining peripheral immunization using interferon gamma (IFNgamma) transduced autologous tumor cells with local intratumoral delivery of interleukin 7 (IL-7) by mesenchymal stromal cells. IL-7 alone significantly decreased the tumor area and this effect was enhanced with IFNgamma immunization. A higher density of intratumoral T-cells was observed in animals receiving combined therapies compared to rats receiving either cytokine alone suggesting that the therapeutic effect is dependent on a T-cell response.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1511913
- author
- Gunnarsson, Salina
LU
; Bexell, Daniel
LU
; Svensson, Andreas
LU
; Siesjö, Peter
LU
; Darabi, Anna
LU
and Bengzon, Johan
LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Neuroimmunology
- volume
- 218
- issue
- 1-2
- pages
- 140 - 144
- publisher
- Elsevier
- external identifiers
-
- wos:000274672700021
- pmid:19914721
- scopus:73349125063
- ISSN
- 1872-8421
- DOI
- 10.1016/j.jneuroim.2009.10.017
- language
- English
- LU publication?
- yes
- id
- 0bfc8e04-4901-4824-bd5c-c579621a5c7a (old id 1511913)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19914721?dopt=Abstract
- date added to LUP
- 2016-04-01 10:41:13
- date last changed
- 2025-10-14 12:33:38
@article{0bfc8e04-4901-4824-bd5c-c579621a5c7a,
abstract = {{The present study reports regression of pre-established experimental rat gliomas as a result of combining peripheral immunization using interferon gamma (IFNgamma) transduced autologous tumor cells with local intratumoral delivery of interleukin 7 (IL-7) by mesenchymal stromal cells. IL-7 alone significantly decreased the tumor area and this effect was enhanced with IFNgamma immunization. A higher density of intratumoral T-cells was observed in animals receiving combined therapies compared to rats receiving either cytokine alone suggesting that the therapeutic effect is dependent on a T-cell response.}},
author = {{Gunnarsson, Salina and Bexell, Daniel and Svensson, Andreas and Siesjö, Peter and Darabi, Anna and Bengzon, Johan}},
issn = {{1872-8421}},
language = {{eng}},
number = {{1-2}},
pages = {{140--144}},
publisher = {{Elsevier}},
series = {{Journal of Neuroimmunology}},
title = {{Intratumoral IL-7 delivery by mesenchymal stromal cells potentiates IFNgamma-transduced tumor cell immunotherapy of experimental glioma.}},
url = {{http://dx.doi.org/10.1016/j.jneuroim.2009.10.017}},
doi = {{10.1016/j.jneuroim.2009.10.017}},
volume = {{218}},
year = {{2010}},
}