Distribution of planar cell polarity proteins in the developing avian retina
(2021) In Experimental Eye Research 209.- Abstract
Planar cell polarity (PCP) is evolutionary conserved and play a critical role in proper tissue development and function. During central nervous system development, PCP proteins exhibit specific patterns of distribution and are indispensable for axonal growth, dendritogenesis, neuronal migration, and neuronal differentiation. The retina constitutes an excellent model in which to study molecular mechanisms involved in neural development. The analysis of the spatiotemporal expression of PCP proteins in this model constitutes an useful histological approach in order to identify possible roles of these proteins in retinogenesis. Immunohistochemical techniques revealed that Frz6, Celsr1, Vangl1, Pk1, Pk3, and Fat1 were present in emerging... (More)
Planar cell polarity (PCP) is evolutionary conserved and play a critical role in proper tissue development and function. During central nervous system development, PCP proteins exhibit specific patterns of distribution and are indispensable for axonal growth, dendritogenesis, neuronal migration, and neuronal differentiation. The retina constitutes an excellent model in which to study molecular mechanisms involved in neural development. The analysis of the spatiotemporal expression of PCP proteins in this model constitutes an useful histological approach in order to identify possible roles of these proteins in retinogenesis. Immunohistochemical techniques revealed that Frz6, Celsr1, Vangl1, Pk1, Pk3, and Fat1 were present in emerging axons from recently differentiated ganglion cells in the chicken retina. Except for Vangl1, they were also asymmetrically distributed in differentiated amacrine cells. Pk1 and Pk3 were restricted in the outer nuclear layer to the outer segment of photoreceptors. Vangl1 was also located in the cell somata of Müller glia. Given these findings together, the distribution of PCP proteins in the developing chicken retina suggest essential roles in axonal guidance during early retinogenesis and a possible involvement in the establishment of cell asymmetry and maintenance of retinal cell phenotypes.
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- author
- Álvarez-Hernán, Guadalupe LU ; Garrido-Jiménez, Sergio ; Román, Ángel Carlos ; Carvajal-González, José María and Francisco-Morcillo, Javier
- publishing date
- 2021-08
- type
- Contribution to journal
- publication status
- published
- keywords
- Animals, Axons/metabolism, Cell Differentiation, Cell Polarity/physiology, Chick Embryo, Models, Animal, Neuroglia/metabolism, Retina/embryology, Retinal Ganglion Cells/cytology
- in
- Experimental Eye Research
- volume
- 209
- article number
- 108681
- publisher
- Elsevier
- external identifiers
-
- pmid:34166683
- scopus:85108603221
- ISSN
- 0014-4835
- DOI
- 10.1016/j.exer.2021.108681
- language
- English
- LU publication?
- no
- additional info
- Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.
- id
- 0c02da69-fd48-4655-a2a0-c4b99c53c63b
- date added to LUP
- 2021-12-15 14:03:30
- date last changed
- 2024-06-15 00:31:43
@article{0c02da69-fd48-4655-a2a0-c4b99c53c63b,
abstract = {{<p>Planar cell polarity (PCP) is evolutionary conserved and play a critical role in proper tissue development and function. During central nervous system development, PCP proteins exhibit specific patterns of distribution and are indispensable for axonal growth, dendritogenesis, neuronal migration, and neuronal differentiation. The retina constitutes an excellent model in which to study molecular mechanisms involved in neural development. The analysis of the spatiotemporal expression of PCP proteins in this model constitutes an useful histological approach in order to identify possible roles of these proteins in retinogenesis. Immunohistochemical techniques revealed that Frz6, Celsr1, Vangl1, Pk1, Pk3, and Fat1 were present in emerging axons from recently differentiated ganglion cells in the chicken retina. Except for Vangl1, they were also asymmetrically distributed in differentiated amacrine cells. Pk1 and Pk3 were restricted in the outer nuclear layer to the outer segment of photoreceptors. Vangl1 was also located in the cell somata of Müller glia. Given these findings together, the distribution of PCP proteins in the developing chicken retina suggest essential roles in axonal guidance during early retinogenesis and a possible involvement in the establishment of cell asymmetry and maintenance of retinal cell phenotypes.</p>}},
author = {{Álvarez-Hernán, Guadalupe and Garrido-Jiménez, Sergio and Román, Ángel Carlos and Carvajal-González, José María and Francisco-Morcillo, Javier}},
issn = {{0014-4835}},
keywords = {{Animals; Axons/metabolism; Cell Differentiation; Cell Polarity/physiology; Chick Embryo; Models, Animal; Neuroglia/metabolism; Retina/embryology; Retinal Ganglion Cells/cytology}},
language = {{eng}},
publisher = {{Elsevier}},
series = {{Experimental Eye Research}},
title = {{Distribution of planar cell polarity proteins in the developing avian retina}},
url = {{http://dx.doi.org/10.1016/j.exer.2021.108681}},
doi = {{10.1016/j.exer.2021.108681}},
volume = {{209}},
year = {{2021}},
}