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Mutation of the key residue for extraribosomal function of ribosomal protein S19 cause increased grooming behaviors in mice

Chen, Jun LU ; Kaitsuka, Taku; Fujino, Rika; Araki, Kimi; Tomizawa, Kazuhito and Yamamoto, Tetsuro (2016) In Neuroscience Letters 629. p.221-226
Abstract

Ribosomal protein S19 (RP S19) possesses ribosomal function as RP S19 monomer and extraribosomal function as cross-linked RP S19 oligomers which function as a ligand of the complement 5a (C5a) receptor (CD88). We have generated a Gln137Glu-RP S19 knock-in (KI) mouse, which is shown to possess the weakened extraribosomal function of RP S19. Because whether the extraribosomal function of RP S19 has a role in brain function had been unclear, we performed behavioral analysis on these mice and demonstrated that KI mice displayed an increased grooming behavior during open-field test and elevated plus maze test and an enhanced freezing behavior in contextual fear conditioning test. These results suggest an involvement of RP S19 oligomers in... (More)

Ribosomal protein S19 (RP S19) possesses ribosomal function as RP S19 monomer and extraribosomal function as cross-linked RP S19 oligomers which function as a ligand of the complement 5a (C5a) receptor (CD88). We have generated a Gln137Glu-RP S19 knock-in (KI) mouse, which is shown to possess the weakened extraribosomal function of RP S19. Because whether the extraribosomal function of RP S19 has a role in brain function had been unclear, we performed behavioral analysis on these mice and demonstrated that KI mice displayed an increased grooming behavior during open-field test and elevated plus maze test and an enhanced freezing behavior in contextual fear conditioning test. These results suggest an involvement of RP S19 oligomers in some anxiety-like behavior, especially grooming behavior.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Anxiety-like behavior, Complement system, Extraribosomal function, Fear memory, Grooming behavior, Ribosomal protein S19
in
Neuroscience Letters
volume
629
pages
6 pages
publisher
Elsevier
external identifiers
  • scopus:84978698035
  • wos:000382409000039
ISSN
0304-3940
DOI
10.1016/j.neulet.2016.07.022
language
English
LU publication?
yes
id
0c191942-2da0-48c1-8a01-4869a6c02d7a
date added to LUP
2016-12-19 14:58:27
date last changed
2017-09-18 11:32:24
@article{0c191942-2da0-48c1-8a01-4869a6c02d7a,
  abstract     = {<p>Ribosomal protein S19 (RP S19) possesses ribosomal function as RP S19 monomer and extraribosomal function as cross-linked RP S19 oligomers which function as a ligand of the complement 5a (C5a) receptor (CD88). We have generated a Gln137Glu-RP S19 knock-in (KI) mouse, which is shown to possess the weakened extraribosomal function of RP S19. Because whether the extraribosomal function of RP S19 has a role in brain function had been unclear, we performed behavioral analysis on these mice and demonstrated that KI mice displayed an increased grooming behavior during open-field test and elevated plus maze test and an enhanced freezing behavior in contextual fear conditioning test. These results suggest an involvement of RP S19 oligomers in some anxiety-like behavior, especially grooming behavior.</p>},
  author       = {Chen, Jun and Kaitsuka, Taku and Fujino, Rika and Araki, Kimi and Tomizawa, Kazuhito and Yamamoto, Tetsuro},
  issn         = {0304-3940},
  keyword      = {Anxiety-like behavior,Complement system,Extraribosomal function,Fear memory,Grooming behavior,Ribosomal protein S19},
  language     = {eng},
  month        = {08},
  pages        = {221--226},
  publisher    = {Elsevier},
  series       = {Neuroscience Letters},
  title        = {Mutation of the key residue for extraribosomal function of ribosomal protein S19 cause increased grooming behaviors in mice},
  url          = {http://dx.doi.org/10.1016/j.neulet.2016.07.022},
  volume       = {629},
  year         = {2016},
}