Mutation of the key residue for extraribosomal function of ribosomal protein S19 cause increased grooming behaviors in mice
(2016) In Neuroscience Letters 629. p.221-226- Abstract
Ribosomal protein S19 (RP S19) possesses ribosomal function as RP S19 monomer and extraribosomal function as cross-linked RP S19 oligomers which function as a ligand of the complement 5a (C5a) receptor (CD88). We have generated a Gln137Glu-RP S19 knock-in (KI) mouse, which is shown to possess the weakened extraribosomal function of RP S19. Because whether the extraribosomal function of RP S19 has a role in brain function had been unclear, we performed behavioral analysis on these mice and demonstrated that KI mice displayed an increased grooming behavior during open-field test and elevated plus maze test and an enhanced freezing behavior in contextual fear conditioning test. These results suggest an involvement of RP S19 oligomers in... (More)
Ribosomal protein S19 (RP S19) possesses ribosomal function as RP S19 monomer and extraribosomal function as cross-linked RP S19 oligomers which function as a ligand of the complement 5a (C5a) receptor (CD88). We have generated a Gln137Glu-RP S19 knock-in (KI) mouse, which is shown to possess the weakened extraribosomal function of RP S19. Because whether the extraribosomal function of RP S19 has a role in brain function had been unclear, we performed behavioral analysis on these mice and demonstrated that KI mice displayed an increased grooming behavior during open-field test and elevated plus maze test and an enhanced freezing behavior in contextual fear conditioning test. These results suggest an involvement of RP S19 oligomers in some anxiety-like behavior, especially grooming behavior.
(Less)
- author
- Chen, Jun LU ; Kaitsuka, Taku ; Fujino, Rika ; Araki, Kimi ; Tomizawa, Kazuhito and Yamamoto, Tetsuro
- organization
- publishing date
- 2016-08-26
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Anxiety-like behavior, Complement system, Extraribosomal function, Fear memory, Grooming behavior, Ribosomal protein S19
- in
- Neuroscience Letters
- volume
- 629
- pages
- 6 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:27424793
- wos:000382409000039
- scopus:84978698035
- ISSN
- 0304-3940
- DOI
- 10.1016/j.neulet.2016.07.022
- language
- English
- LU publication?
- yes
- id
- 0c191942-2da0-48c1-8a01-4869a6c02d7a
- date added to LUP
- 2016-12-19 14:58:27
- date last changed
- 2024-11-16 13:45:01
@article{0c191942-2da0-48c1-8a01-4869a6c02d7a,
abstract = {{<p>Ribosomal protein S19 (RP S19) possesses ribosomal function as RP S19 monomer and extraribosomal function as cross-linked RP S19 oligomers which function as a ligand of the complement 5a (C5a) receptor (CD88). We have generated a Gln137Glu-RP S19 knock-in (KI) mouse, which is shown to possess the weakened extraribosomal function of RP S19. Because whether the extraribosomal function of RP S19 has a role in brain function had been unclear, we performed behavioral analysis on these mice and demonstrated that KI mice displayed an increased grooming behavior during open-field test and elevated plus maze test and an enhanced freezing behavior in contextual fear conditioning test. These results suggest an involvement of RP S19 oligomers in some anxiety-like behavior, especially grooming behavior.</p>}},
author = {{Chen, Jun and Kaitsuka, Taku and Fujino, Rika and Araki, Kimi and Tomizawa, Kazuhito and Yamamoto, Tetsuro}},
issn = {{0304-3940}},
keywords = {{Anxiety-like behavior; Complement system; Extraribosomal function; Fear memory; Grooming behavior; Ribosomal protein S19}},
language = {{eng}},
month = {{08}},
pages = {{221--226}},
publisher = {{Elsevier}},
series = {{Neuroscience Letters}},
title = {{Mutation of the key residue for extraribosomal function of ribosomal protein S19 cause increased grooming behaviors in mice}},
url = {{http://dx.doi.org/10.1016/j.neulet.2016.07.022}},
doi = {{10.1016/j.neulet.2016.07.022}},
volume = {{629}},
year = {{2016}},
}