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Determinants for local tumour control probability after radiotherapy of anal cancer

Johnsson, Anders LU ; Leon, Otilia LU ; Gunnlaugsson, Adalsteinn LU ; Nilsson, Per LU and Höglund, Peter LU (2018) In Radiotherapy and Oncology 128(2). p.380-386
Abstract

Background and purpose: Anal squamous cell carcinoma is primarily treated with radiotherapy (RT), but the optimal RT dose for anal tumours of different sizes is not known. The purpose of this study was to identify determinants for local tumour control probability (LTCP). Material and methods: From a large Nordic database 901 patients who received RT for anal cancer between 2000 and 2007 were selected. LTCP was analysed in a series of uni- and multivariable regression analyses. Results: Higher RT dose, female gender and addition of chemotherapy were associated with higher LTCP whereas increasing tumour size, tumour invasiveness (stage T4) and lymph node metastases (N+) were associated with lower LTCP. Male patients needed approximately... (More)

Background and purpose: Anal squamous cell carcinoma is primarily treated with radiotherapy (RT), but the optimal RT dose for anal tumours of different sizes is not known. The purpose of this study was to identify determinants for local tumour control probability (LTCP). Material and methods: From a large Nordic database 901 patients who received RT for anal cancer between 2000 and 2007 were selected. LTCP was analysed in a series of uni- and multivariable regression analyses. Results: Higher RT dose, female gender and addition of chemotherapy were associated with higher LTCP whereas increasing tumour size, tumour invasiveness (stage T4) and lymph node metastases (N+) were associated with lower LTCP. Male patients needed approximately 10 Gy higher RT dose than female patients for similar LTCP. The addition of chemotherapy corresponded to 5–10 Gy RT dose. Conclusions: Our results basically support current guidelines recommending: (1) lower RT dose in small tumours (<4 cm), (2) higher RT dose larger tumours and in stages T4 and /or N+, (3) Chemo should be used in combination with RT. These results will hopefully constitute the basis for future trials, aiming at individualized RT dosing in patients with anal cancer.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Anal cancer, Radiotherapy, TCP
in
Radiotherapy and Oncology
volume
128
issue
2
pages
380 - 386
publisher
Elsevier
external identifiers
  • scopus:85048706670
ISSN
0167-8140
DOI
10.1016/j.radonc.2018.06.007
language
English
LU publication?
yes
id
0c35ed03-63d1-46b4-ab60-b2e70fb0293d
date added to LUP
2018-07-03 11:02:41
date last changed
2019-08-14 04:19:23
@article{0c35ed03-63d1-46b4-ab60-b2e70fb0293d,
  abstract     = {<p>Background and purpose: Anal squamous cell carcinoma is primarily treated with radiotherapy (RT), but the optimal RT dose for anal tumours of different sizes is not known. The purpose of this study was to identify determinants for local tumour control probability (LTCP). Material and methods: From a large Nordic database 901 patients who received RT for anal cancer between 2000 and 2007 were selected. LTCP was analysed in a series of uni- and multivariable regression analyses. Results: Higher RT dose, female gender and addition of chemotherapy were associated with higher LTCP whereas increasing tumour size, tumour invasiveness (stage T4) and lymph node metastases (N+) were associated with lower LTCP. Male patients needed approximately 10 Gy higher RT dose than female patients for similar LTCP. The addition of chemotherapy corresponded to 5–10 Gy RT dose. Conclusions: Our results basically support current guidelines recommending: (1) lower RT dose in small tumours (&lt;4 cm), (2) higher RT dose larger tumours and in stages T4 and /or N+, (3) Chemo should be used in combination with RT. These results will hopefully constitute the basis for future trials, aiming at individualized RT dosing in patients with anal cancer.</p>},
  author       = {Johnsson, Anders and Leon, Otilia and Gunnlaugsson, Adalsteinn and Nilsson, Per and Höglund, Peter},
  issn         = {0167-8140},
  keyword      = {Anal cancer,Radiotherapy,TCP},
  language     = {eng},
  month        = {01},
  number       = {2},
  pages        = {380--386},
  publisher    = {Elsevier},
  series       = {Radiotherapy and Oncology},
  title        = {Determinants for local tumour control probability after radiotherapy of anal cancer},
  url          = {http://dx.doi.org/10.1016/j.radonc.2018.06.007},
  volume       = {128},
  year         = {2018},
}