Polyketide synthesis genes associated with toxin production in two species of Gambierdiscus (Dinophyceae).
(2015) In BMC Genomics 16.- Abstract
- Marine microbial protists, in particular, dinoflagellates, produce polyketide toxins with ecosystem-wide and human health impacts. Species of Gambierdiscus produce the polyether ladder compounds ciguatoxins and maitotoxins, which can lead to ciguatera fish poisoning, a serious human illness associated with reef fish consumption. Genes associated with the biosynthesis of polyether ladder compounds are yet to be elucidated, however, stable isotope feeding studies of such compounds consistently support their polyketide origin indicating that polyketide synthases are involved in their biosynthesis.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5442101
- author
- Kohli, Gurjeet S ; John, Uwe ; Figueroa, Rosa LU ; Rhodes, Lesley L ; Harwood, D Tim ; Groth, Marco ; Bolch, Christopher J S and Murray, Shauna A
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- BMC Genomics
- volume
- 16
- article number
- 410
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:26016672
- wos:000355146100002
- pmid:26016672
- scopus:85019175095
- ISSN
- 1471-2164
- DOI
- 10.1186/s12864-015-1625-y
- language
- English
- LU publication?
- yes
- id
- 0c3802a8-25b2-4b47-ae9f-ea487f1a1f52 (old id 5442101)
- date added to LUP
- 2016-04-01 14:19:41
- date last changed
- 2022-04-14 17:16:48
@article{0c3802a8-25b2-4b47-ae9f-ea487f1a1f52, abstract = {{Marine microbial protists, in particular, dinoflagellates, produce polyketide toxins with ecosystem-wide and human health impacts. Species of Gambierdiscus produce the polyether ladder compounds ciguatoxins and maitotoxins, which can lead to ciguatera fish poisoning, a serious human illness associated with reef fish consumption. Genes associated with the biosynthesis of polyether ladder compounds are yet to be elucidated, however, stable isotope feeding studies of such compounds consistently support their polyketide origin indicating that polyketide synthases are involved in their biosynthesis.}}, author = {{Kohli, Gurjeet S and John, Uwe and Figueroa, Rosa and Rhodes, Lesley L and Harwood, D Tim and Groth, Marco and Bolch, Christopher J S and Murray, Shauna A}}, issn = {{1471-2164}}, language = {{eng}}, publisher = {{BioMed Central (BMC)}}, series = {{BMC Genomics}}, title = {{Polyketide synthesis genes associated with toxin production in two species of Gambierdiscus (Dinophyceae).}}, url = {{http://dx.doi.org/10.1186/s12864-015-1625-y}}, doi = {{10.1186/s12864-015-1625-y}}, volume = {{16}}, year = {{2015}}, }