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Biomechanical, histological, and computed X-ray tomographic analyses of hydroxyapatite coated PEEK implants in an extended healing model in rabbit

Johansson, Pär; Barkarmo, Sargon; Hawthan, Mohammed; Peruzzi, Niccolò LU ; Kjellin, Per and Wennerberg, Ann (2018) In Journal of Biomedical Materials Research - Part A 106(5). p.1440-1447
Abstract

A nanosized hydroxyapatite (HA) modification on polyetheretherketone (PEEK) using a novel spin coating technique was investigated in a rabbit model. Spin coating technique creates a 20–40 nm thick layer of nanosized HA particles with similar shape, size, and crystallinity as human bone. Some implants were designed with a perforating hole in the apical region to mimic a fusion chamber of a spinal implant. The coating nano-structures were assessed using a scanning electron microscope. The in vivo response to HA-PEEK was compared to untreated PEEK with respect to removal torque, histomorphometry, and computed microtomography. The HA-coated and pure PEEK implants were inserted in the tibia and femur bone according to simple randomization.... (More)

A nanosized hydroxyapatite (HA) modification on polyetheretherketone (PEEK) using a novel spin coating technique was investigated in a rabbit model. Spin coating technique creates a 20–40 nm thick layer of nanosized HA particles with similar shape, size, and crystallinity as human bone. Some implants were designed with a perforating hole in the apical region to mimic a fusion chamber of a spinal implant. The coating nano-structures were assessed using a scanning electron microscope. The in vivo response to HA-PEEK was compared to untreated PEEK with respect to removal torque, histomorphometry, and computed microtomography. The HA-coated and pure PEEK implants were inserted in the tibia and femur bone according to simple randomization. The rabbits were sacrificed 20 weeks after implantation. Removal torque analysis showed significantly higher values for HA-PEEK. Qualitative histological evaluation revealed an intimate contact between PEEK and the bone at the threads and perforated hole. Histomorphometric assessment showed higher bone-implant and bone area values for HA-PEEK but without statistical significance. The effect of the HA coating showed most prominent effect in the removal torque which may be correlated to an alteration in the bone quality around the HA-PEEK implants.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
HA, histology, hydroxyapatite, in vivo, osseointegration, polyether ether ketone
in
Journal of Biomedical Materials Research - Part A
volume
106
issue
5
pages
8 pages
publisher
John Wiley & Sons
external identifiers
  • scopus:85042167153
ISSN
1549-3296
DOI
10.1002/jbm.a.36345
language
English
LU publication?
yes
id
0c428b85-407f-47f0-997d-1e69a480a4ad
date added to LUP
2018-05-22 14:21:38
date last changed
2019-04-10 04:08:33
@article{0c428b85-407f-47f0-997d-1e69a480a4ad,
  abstract     = {<p>A nanosized hydroxyapatite (HA) modification on polyetheretherketone (PEEK) using a novel spin coating technique was investigated in a rabbit model. Spin coating technique creates a 20–40 nm thick layer of nanosized HA particles with similar shape, size, and crystallinity as human bone. Some implants were designed with a perforating hole in the apical region to mimic a fusion chamber of a spinal implant. The coating nano-structures were assessed using a scanning electron microscope. The in vivo response to HA-PEEK was compared to untreated PEEK with respect to removal torque, histomorphometry, and computed microtomography. The HA-coated and pure PEEK implants were inserted in the tibia and femur bone according to simple randomization. The rabbits were sacrificed 20 weeks after implantation. Removal torque analysis showed significantly higher values for HA-PEEK. Qualitative histological evaluation revealed an intimate contact between PEEK and the bone at the threads and perforated hole. Histomorphometric assessment showed higher bone-implant and bone area values for HA-PEEK but without statistical significance. The effect of the HA coating showed most prominent effect in the removal torque which may be correlated to an alteration in the bone quality around the HA-PEEK implants.</p>},
  author       = {Johansson, Pär and Barkarmo, Sargon and Hawthan, Mohammed and Peruzzi, Niccolò and Kjellin, Per and Wennerberg, Ann},
  issn         = {1549-3296},
  keyword      = {HA,histology,hydroxyapatite,in vivo,osseointegration,polyether ether ketone},
  language     = {eng},
  month        = {05},
  number       = {5},
  pages        = {1440--1447},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Biomedical Materials Research - Part A},
  title        = {Biomechanical, histological, and computed X-ray tomographic analyses of hydroxyapatite coated PEEK implants in an extended healing model in rabbit},
  url          = {http://dx.doi.org/10.1002/jbm.a.36345},
  volume       = {106},
  year         = {2018},
}