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Changes in human fetal oxygenation during maternal hyperoxia as estimated by BOLD MRI

Sorensen, Anne ; Peters, David ; Simonsen, Carsten ; Pedersen, Michael ; Stausbol-Gron, Brian ; Christiansen, Ole Bjarne ; Lingman, Göran LU and Uldbjerg, Niels (2013) In Prenatal Diagnosis 33(2). p.141-145
Abstract
Objective Changes in blood oxygen level dependent (BOLD) magnetic resonance imaging (MRI) signal are closely related to changes in fetal oxygenation. In this study, we aimed to investigate the changes in human fetal oxygenation during maternal hyperoxia by using the non-invasive BOLD MRI technique. Method Eight healthy pregnant women in gestational week 28 to 34 were included. With the use of a facial oxygen mask, we induced maternal hyperoxia and measured changes in the BOLD MRI signal of selected fetal organs. Results In a number of fetal organs, the BOLD MRI signal increased significantly (P<0.01) during maternal hyperoxia (mean change in %+/- SEM): liver (14.3 +/- 3.7%), spleen (15.2 +/- 3.5%) and kidney (6.2 +/- 1.8%) as well as... (More)
Objective Changes in blood oxygen level dependent (BOLD) magnetic resonance imaging (MRI) signal are closely related to changes in fetal oxygenation. In this study, we aimed to investigate the changes in human fetal oxygenation during maternal hyperoxia by using the non-invasive BOLD MRI technique. Method Eight healthy pregnant women in gestational week 28 to 34 were included. With the use of a facial oxygen mask, we induced maternal hyperoxia and measured changes in the BOLD MRI signal of selected fetal organs. Results In a number of fetal organs, the BOLD MRI signal increased significantly (P<0.01) during maternal hyperoxia (mean change in %+/- SEM): liver (14.3 +/- 3.7%), spleen (15.2 +/- 3.5%) and kidney (6.2 +/- 1.8%) as well as the placenta (6.5 +/- 1.6%). In the fetal brain, however, the BOLD MRI signal remained constant (0.3 +/- 0.2%). Conclusion During maternal hyperoxia, we demonstrated an increased oxygenation in a number of human fetal organs by using the non-invasive BOLD technique. The oxygenation of the fetal brain remained constant, thus a reversed' brain sparing mechanism could be considered in healthy fetuses subjected to hyperoxia. (c) 2012 John Wiley & Sons, Ltd. (Less)
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type
Contribution to journal
publication status
published
subject
in
Prenatal Diagnosis
volume
33
issue
2
pages
141 - 145
publisher
John Wiley and Sons
external identifiers
  • wos:000314493500007
  • scopus:84873262916
  • pmid:23233459
ISSN
1097-0223
DOI
10.1002/pd.4025
language
English
LU publication?
yes
id
0c56eeb3-881f-456f-90dc-46b1e0769351 (old id 3589956)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23233459
date added to LUP
2016-04-01 10:14:53
date last changed
2021-01-06 05:49:20
@article{0c56eeb3-881f-456f-90dc-46b1e0769351,
  abstract     = {Objective Changes in blood oxygen level dependent (BOLD) magnetic resonance imaging (MRI) signal are closely related to changes in fetal oxygenation. In this study, we aimed to investigate the changes in human fetal oxygenation during maternal hyperoxia by using the non-invasive BOLD MRI technique. Method Eight healthy pregnant women in gestational week 28 to 34 were included. With the use of a facial oxygen mask, we induced maternal hyperoxia and measured changes in the BOLD MRI signal of selected fetal organs. Results In a number of fetal organs, the BOLD MRI signal increased significantly (P&lt;0.01) during maternal hyperoxia (mean change in %+/- SEM): liver (14.3 +/- 3.7%), spleen (15.2 +/- 3.5%) and kidney (6.2 +/- 1.8%) as well as the placenta (6.5 +/- 1.6%). In the fetal brain, however, the BOLD MRI signal remained constant (0.3 +/- 0.2%). Conclusion During maternal hyperoxia, we demonstrated an increased oxygenation in a number of human fetal organs by using the non-invasive BOLD technique. The oxygenation of the fetal brain remained constant, thus a reversed' brain sparing mechanism could be considered in healthy fetuses subjected to hyperoxia. (c) 2012 John Wiley &amp; Sons, Ltd.},
  author       = {Sorensen, Anne and Peters, David and Simonsen, Carsten and Pedersen, Michael and Stausbol-Gron, Brian and Christiansen, Ole Bjarne and Lingman, Göran and Uldbjerg, Niels},
  issn         = {1097-0223},
  language     = {eng},
  number       = {2},
  pages        = {141--145},
  publisher    = {John Wiley and Sons},
  series       = {Prenatal Diagnosis},
  title        = {Changes in human fetal oxygenation during maternal hyperoxia as estimated by BOLD MRI},
  url          = {http://dx.doi.org/10.1002/pd.4025},
  doi          = {10.1002/pd.4025},
  volume       = {33},
  year         = {2013},
}