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RIFM fragrance ingredient safety assessment, p-Isopropylbenzyl acetate, CAS Registry Number 59230-57-8

Api, A. M.; Belsito, D.; Bhatia, S.; Bruze, Magnus LU ; Calow, P.; Dagli, M. L.; Dekant, W.; Fryer, A. D.; Kromidas, L. and La Cava, S., et al. (2016) In Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 97(Suppl.). p.69-79
Abstract

The use of this material under current use conditions is supported by the existing information.This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization, as well as environmental safety. Data from the suitable read across analog, benzyl acetate (CAS # 140-11-4), show that this material is not genotoxic nor does it have skin sensitization potential. The repeated dose, developmental and reproductive, and local respiratory toxicity endpoints were completed using benzyl acetate (CAS # 140-11-4) as a suitable read across analog, which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed... (More)

The use of this material under current use conditions is supported by the existing information.This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization, as well as environmental safety. Data from the suitable read across analog, benzyl acetate (CAS # 140-11-4), show that this material is not genotoxic nor does it have skin sensitization potential. The repeated dose, developmental and reproductive, and local respiratory toxicity endpoints were completed using benzyl acetate (CAS # 140-11-4) as a suitable read across analog, which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.

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publication status
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keywords
Environmental safety, Genotoxicity, Local respiratory toxicity, Phototoxicity/photoallergenicity, Repeated dose, developmental and reproductive toxicity, Skin sensitization
in
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
volume
97
issue
Suppl.
pages
69 - 79
publisher
Elsevier
external identifiers
  • scopus:84964402360
ISSN
0278-6915
DOI
10.1016/j.fct.2016.04.002
language
English
LU publication?
yes
id
0c76ae27-3a43-42d6-b9a1-761a2543372d
date added to LUP
2016-10-04 14:27:23
date last changed
2017-04-25 08:23:42
@article{0c76ae27-3a43-42d6-b9a1-761a2543372d,
  abstract     = {<p>The use of this material under current use conditions is supported by the existing information.This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization, as well as environmental safety. Data from the suitable read across analog, benzyl acetate (CAS # 140-11-4), show that this material is not genotoxic nor does it have skin sensitization potential. The repeated dose, developmental and reproductive, and local respiratory toxicity endpoints were completed using benzyl acetate (CAS # 140-11-4) as a suitable read across analog, which provided a MOE &gt; 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.</p>},
  author       = {Api, A. M. and Belsito, D. and Bhatia, S. and Bruze, Magnus and Calow, P. and Dagli, M. L. and Dekant, W. and Fryer, A. D. and Kromidas, L. and La Cava, S. and Lalko, J. F. and Lapczynski, A. and Liebler, D. C. and Politano, V. T. and Ritacco, G. and Salvito, D. and Schultz, T. W. and Shen, J. and Sipes, I. G. and Wall, B. and Wilcox, D. K.},
  issn         = {0278-6915},
  keyword      = {Environmental safety,Genotoxicity,Local respiratory toxicity,Phototoxicity/photoallergenicity,Repeated dose, developmental and reproductive toxicity,Skin sensitization},
  language     = {eng},
  number       = {Suppl.},
  pages        = {69--79},
  publisher    = {Elsevier},
  series       = {Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  title        = {RIFM fragrance ingredient safety assessment, p-Isopropylbenzyl acetate, CAS Registry Number 59230-57-8},
  url          = {http://dx.doi.org/10.1016/j.fct.2016.04.002},
  volume       = {97},
  year         = {2016},
}