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Analysis of HLA‐DQA1 and ‐DQB1 genes in Mexican Americans with insulin‐dependent diabetes mellitus

Sanjeevi, C. B. ; Zeidler, A. ; Shaw, S. ; Rotter, J. ; Nepom, G. T. ; Costin, G. ; Raffel, L. ; Eastman, S. ; Kockum, I. and Wassmuth, R. , et al. (1993) In Tissue Antigens 42(1). p.72-77
Abstract

Abstract: Mexican American patients (n = 35) with insulin‐dependent diabetes mellitus (IDDM) and control subjects (n = 39) were HLA‐DQA and DQB typed by the polymerase chain reaction technique combined with allele‐specific oligonucleotide probes. Either DQBl*0302 or DQB1*0201 was present among 91% (32/35) of the patients compared to 67% (26/39) of controls. Either DQA1*0501 or DQA1*0301 was present in all patients (100% or 35/35) compared to 29/39 (74%) (OR 12.06 Pc<0.05) of controls. All four of these genes, in cis or trans, were present in 15/35 (43%) of the patients compared to 3/39 (8%) of controls (OR 9.0; Pc<0.01). The presence of one or more non‐susceptibility alleles showed a dose‐related decrease in relative risk.... (More)

Abstract: Mexican American patients (n = 35) with insulin‐dependent diabetes mellitus (IDDM) and control subjects (n = 39) were HLA‐DQA and DQB typed by the polymerase chain reaction technique combined with allele‐specific oligonucleotide probes. Either DQBl*0302 or DQB1*0201 was present among 91% (32/35) of the patients compared to 67% (26/39) of controls. Either DQA1*0501 or DQA1*0301 was present in all patients (100% or 35/35) compared to 29/39 (74%) (OR 12.06 Pc<0.05) of controls. All four of these genes, in cis or trans, were present in 15/35 (43%) of the patients compared to 3/39 (8%) of controls (OR 9.0; Pc<0.01). The presence of one or more non‐susceptibility alleles showed a dose‐related decrease in relative risk. Presence of aspartic acid (Asp) at position 57 of the DQ β chain did not confer protection and non‐Asp homozygozity did not confer susceptibility to IDDM in this ethnic group. In conclusion, susceptibility to IDDM in Mexican Americans is associated with particular DQA and DQB combinations, illustrates dose‐dependent parameters and contradicts the critical residue hypothesis. 1993 Blackwell Munksgaard

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publishing date
type
Contribution to journal
publication status
published
keywords
type I (insulin‐dependent) diabetes – HLA‐DQ – genetic susceptibility
in
Tissue Antigens
volume
42
issue
1
pages
72 - 77
publisher
Wiley-Blackwell
external identifiers
  • pmid:7903490
  • scopus:0027445088
ISSN
0001-2815
DOI
10.1111/j.1399-0039.1993.tb02170.x
language
English
LU publication?
no
id
0c79eefc-ec18-46a2-9dc5-292a1397b2a7
date added to LUP
2019-09-11 09:26:28
date last changed
2020-08-02 06:53:23
@article{0c79eefc-ec18-46a2-9dc5-292a1397b2a7,
  abstract     = {<p>Abstract:  Mexican American patients (n = 35) with insulin‐dependent diabetes mellitus (IDDM) and control subjects (n = 39) were HLA‐DQA and DQB typed by the polymerase chain reaction technique combined with allele‐specific oligonucleotide probes. Either DQBl*0302 or DQB1*0201 was present among 91% (32/35) of the patients compared to 67% (26/39) of controls. Either DQA1*0501 or DQA1*0301 was present in all patients (100% or 35/35) compared to 29/39 (74%) (OR 12.06 Pc&lt;0.05) of controls. All four of these genes, in cis or trans, were present in 15/35 (43%) of the patients compared to 3/39 (8%) of controls (OR 9.0; Pc&lt;0.01). The presence of one or more non‐susceptibility alleles showed a dose‐related decrease in relative risk. Presence of aspartic acid (Asp) at position 57 of the DQ β chain did not confer protection and non‐Asp homozygozity did not confer susceptibility to IDDM in this ethnic group. In conclusion, susceptibility to IDDM in Mexican Americans is associated with particular DQA and DQB combinations, illustrates dose‐dependent parameters and contradicts the critical residue hypothesis. 1993 Blackwell Munksgaard</p>},
  author       = {Sanjeevi, C. B. and Zeidler, A. and Shaw, S. and Rotter, J. and Nepom, G. T. and Costin, G. and Raffel, L. and Eastman, S. and Kockum, I. and Wassmuth, R. and Lernmark, Å},
  issn         = {0001-2815},
  language     = {eng},
  month        = {01},
  number       = {1},
  pages        = {72--77},
  publisher    = {Wiley-Blackwell},
  series       = {Tissue Antigens},
  title        = {Analysis of HLA‐DQA1 and ‐DQB1 genes in Mexican Americans with insulin‐dependent diabetes mellitus},
  url          = {http://dx.doi.org/10.1111/j.1399-0039.1993.tb02170.x},
  doi          = {10.1111/j.1399-0039.1993.tb02170.x},
  volume       = {42},
  year         = {1993},
}