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Effects of hydration on plasma copeptin, glycemia and gluco-regulatory hormones : a water intervention in humans

Enhörning, Sofia LU ; Tasevska, Irina LU ; Roussel, Ronan; Bouby, Nadine; Persson, Margaretha LU ; Burri, Philippe LU ; Bankir, Lise and Melander, Olle LU (2017) In European Journal of Nutrition p.1-10
Abstract

Purpose: High plasma copeptin, a marker of vasopressin, predicts diabetes mellitus. We tested if copeptin could be suppressed by increased water intake in healthy individuals, and if a water-induced change in copeptin was accompanied by altered concentrations of glucose, insulin or glucagon. Methods: Thirty-nine healthy individuals underwent, in random order, 1 week of high water intake (3 L/day on top of habitual intake) and 1 week of normal (habitual) fluid intake (control). Fasting plasma concentrations of copeptin, glucose, insulin and glucagon were compared between the ends of both periods. Furthermore, acute copeptin kinetics were mapped for 4 h after ingestion of 1 L of water. Results: After acute intake of 1 L water, copeptin... (More)

Purpose: High plasma copeptin, a marker of vasopressin, predicts diabetes mellitus. We tested if copeptin could be suppressed by increased water intake in healthy individuals, and if a water-induced change in copeptin was accompanied by altered concentrations of glucose, insulin or glucagon. Methods: Thirty-nine healthy individuals underwent, in random order, 1 week of high water intake (3 L/day on top of habitual intake) and 1 week of normal (habitual) fluid intake (control). Fasting plasma concentrations of copeptin, glucose, insulin and glucagon were compared between the ends of both periods. Furthermore, acute copeptin kinetics were mapped for 4 h after ingestion of 1 L of water. Results: After acute intake of 1 L water, copeptin was significantly reduced within 30 min, and reached maximum reduction within 90 min with on average 39% reduction (95% confidence interval (95 CI) 34–45) (p < 0.001) and remained low the entire test period (4 h). One week of increased water intake led to a 15% reduction (95 CI 5–25) (p = 0.003) of copeptin compared to control week. The greatest reduction occurred among subjects with habitually high copeptin and concentrated urine (“water-responders”). Water-responders had significant water-induced reduction of glucagon, but glucose and insulin were unaffected. Conclusions: Both acute and 1 week extra water intake potently reduced copeptin concentration. In those with the greatest decline (water-responders), who are typically low drinkers with high baseline copeptin, water induced a reduction in fasting glucagon. Long-term trials assessing the effect of water on glucometabolic traits should focus on low-water drinkers with high copeptin concentration.

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author
organization
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type
Contribution to journal
publication status
epub
subject
keywords
Glucagon, Insulin, OGTT, Vasopressin, Water
in
European Journal of Nutrition
pages
10 pages
publisher
Springer
external identifiers
  • scopus:85038114965
ISSN
1436-6207
DOI
10.1007/s00394-017-1595-8
language
English
LU publication?
yes
id
0ca3a1a4-7a59-4981-a7d9-31e77cb83509
date added to LUP
2018-01-03 13:23:26
date last changed
2018-10-28 01:41:00
@article{0ca3a1a4-7a59-4981-a7d9-31e77cb83509,
  abstract     = {<p>Purpose: High plasma copeptin, a marker of vasopressin, predicts diabetes mellitus. We tested if copeptin could be suppressed by increased water intake in healthy individuals, and if a water-induced change in copeptin was accompanied by altered concentrations of glucose, insulin or glucagon. Methods: Thirty-nine healthy individuals underwent, in random order, 1 week of high water intake (3 L/day on top of habitual intake) and 1 week of normal (habitual) fluid intake (control). Fasting plasma concentrations of copeptin, glucose, insulin and glucagon were compared between the ends of both periods. Furthermore, acute copeptin kinetics were mapped for 4 h after ingestion of 1 L of water. Results: After acute intake of 1 L water, copeptin was significantly reduced within 30 min, and reached maximum reduction within 90 min with on average 39% reduction (95% confidence interval (95 CI) 34–45) (p &lt; 0.001) and remained low the entire test period (4 h). One week of increased water intake led to a 15% reduction (95 CI 5–25) (p = 0.003) of copeptin compared to control week. The greatest reduction occurred among subjects with habitually high copeptin and concentrated urine (“water-responders”). Water-responders had significant water-induced reduction of glucagon, but glucose and insulin were unaffected. Conclusions: Both acute and 1 week extra water intake potently reduced copeptin concentration. In those with the greatest decline (water-responders), who are typically low drinkers with high baseline copeptin, water induced a reduction in fasting glucagon. Long-term trials assessing the effect of water on glucometabolic traits should focus on low-water drinkers with high copeptin concentration.</p>},
  author       = {Enhörning, Sofia and Tasevska, Irina and Roussel, Ronan and Bouby, Nadine and Persson, Margaretha and Burri, Philippe and Bankir, Lise and Melander, Olle},
  issn         = {1436-6207},
  keyword      = {Glucagon,Insulin,OGTT,Vasopressin,Water},
  language     = {eng},
  month        = {12},
  pages        = {1--10},
  publisher    = {Springer},
  series       = {European Journal of Nutrition},
  title        = {Effects of hydration on plasma copeptin, glycemia and gluco-regulatory hormones : a water intervention in humans},
  url          = {http://dx.doi.org/10.1007/s00394-017-1595-8},
  year         = {2017},
}