Numerical investigation of the influence of the source and detector position for optical measurement of lung volume and oxygen content in preterm infants
(2022) In Journal of Biophotonics 15(7).- Abstract
There is an urgent need for improved respiratory surveillance of preterm infants. Gas in scattering media absorption spectroscopy (GASMAS) is emerging as a potential clinical cutaneous monitoring tool of lung functions in neonates. A challenge in the clinical translation of GASMAS is to obtain sufficiently high signal-to-noise ratios in the measurements, since the light attenuation is high in human tissue. Previous GASMAS studies on piglets have shown higher signal quality with an internal source, as more light propagates through the lung and the loss due to scattering and absorption is less. In this article we simulated light propagation with an intratracheal and a dermal source, and investigated the signal quality and lung volume... (More)
There is an urgent need for improved respiratory surveillance of preterm infants. Gas in scattering media absorption spectroscopy (GASMAS) is emerging as a potential clinical cutaneous monitoring tool of lung functions in neonates. A challenge in the clinical translation of GASMAS is to obtain sufficiently high signal-to-noise ratios in the measurements, since the light attenuation is high in human tissue. Previous GASMAS studies on piglets have shown higher signal quality with an internal source, as more light propagates through the lung and the loss due to scattering and absorption is less. In this article we simulated light propagation with an intratracheal and a dermal source, and investigated the signal quality and lung volume probed. The results suggest that GASMAS has the potential to measure respiratory volumes; and the sensitivity is higher for an intratracheal source which also enables to probe most of the lung.
(Less)
- author
- Pacheco, Andrea ; Jayet, Baptiste ; Svanberg, Emilie Krite LU ; Dehghani, Hamid ; Dempsey, Eugene and Andersson-Engels, Stefan
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- computational model of a thorax, light transport, preterm infants, tuneable diode laser absorption spectroscopy
- in
- Journal of Biophotonics
- volume
- 15
- issue
- 7
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:35340113
- scopus:85128051221
- ISSN
- 1864-063X
- DOI
- 10.1002/jbio.202200041
- language
- English
- LU publication?
- yes
- id
- 0ca77721-ccea-4215-b667-0cda8385f23c
- date added to LUP
- 2022-06-15 11:59:22
- date last changed
- 2024-06-27 16:58:57
@article{0ca77721-ccea-4215-b667-0cda8385f23c,
abstract = {{<p>There is an urgent need for improved respiratory surveillance of preterm infants. Gas in scattering media absorption spectroscopy (GASMAS) is emerging as a potential clinical cutaneous monitoring tool of lung functions in neonates. A challenge in the clinical translation of GASMAS is to obtain sufficiently high signal-to-noise ratios in the measurements, since the light attenuation is high in human tissue. Previous GASMAS studies on piglets have shown higher signal quality with an internal source, as more light propagates through the lung and the loss due to scattering and absorption is less. In this article we simulated light propagation with an intratracheal and a dermal source, and investigated the signal quality and lung volume probed. The results suggest that GASMAS has the potential to measure respiratory volumes; and the sensitivity is higher for an intratracheal source which also enables to probe most of the lung.</p>}},
author = {{Pacheco, Andrea and Jayet, Baptiste and Svanberg, Emilie Krite and Dehghani, Hamid and Dempsey, Eugene and Andersson-Engels, Stefan}},
issn = {{1864-063X}},
keywords = {{computational model of a thorax; light transport; preterm infants; tuneable diode laser absorption spectroscopy}},
language = {{eng}},
number = {{7}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Journal of Biophotonics}},
title = {{Numerical investigation of the influence of the source and detector position for optical measurement of lung volume and oxygen content in preterm infants}},
url = {{http://dx.doi.org/10.1002/jbio.202200041}},
doi = {{10.1002/jbio.202200041}},
volume = {{15}},
year = {{2022}},
}