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Who are the long-term survivors of recurrent ovarian carcinoma? : a retrospective analysis of a multicenter study

Yoshihara, Masato ; Mogi, Kazumasa ; Kitami, Kazuhisa ; Uno, Kaname LU orcid ; Iyoshi, Shohei ; Tano, Sho ; Fujimoto, Hiroki ; Miyamoto, Emiri ; Yoshikawa, Nobuhisa and Emoto, Ryo , et al. (2022) In International Journal of Clinical Oncology 27(10). p.1660-1668
Abstract

Background: The aim of the present study was to investigate the incidence and hallmarks of long-term survivors of recurrent ovarian carcinoma (LTSROC) in a large-scale retrospective cohort of patients from a multicenter study group. Methods: We performed a regional multicenter retrospective study between January 1986 and September 2021 using clinical data collected under the central pathological review system. Patients who underwent surgery for primary OC at diagnosis and developed recurrent tumors after the initial treatment were included. We defined LTSROC as patients who survived for 5 years or longer after initial tumor recurrence and examined factors affecting the long-term survival of ROC and outcomes of LTSROC. Results: We... (More)

Background: The aim of the present study was to investigate the incidence and hallmarks of long-term survivors of recurrent ovarian carcinoma (LTSROC) in a large-scale retrospective cohort of patients from a multicenter study group. Methods: We performed a regional multicenter retrospective study between January 1986 and September 2021 using clinical data collected under the central pathological review system. Patients who underwent surgery for primary OC at diagnosis and developed recurrent tumors after the initial treatment were included. We defined LTSROC as patients who survived for 5 years or longer after initial tumor recurrence and examined factors affecting the long-term survival of ROC and outcomes of LTSROC. Results: We collected information on patients with malignant ovarian tumors and finally 657 of them that developed ROC were included in the study population. Sixty-eight (10.4%) patients were LTSROC while 399 (60.7%) were short-term survivors of recurrent ovarian carcinoma. In a multivariate logistic regression analysis, negative ascites cytology [odds ratio (OR) 1.865; 95% CI 1.026–3.393; p = 0.041] and a recurrence-free interval (RFI) of 1 year or longer (OR 2.896; 95% CI 1.546–5.425; p < 0.001) were identified as independent factors associated with LTSROC. Approximately 80% of LTSROC presented with solitary recurrent tumors. Furthermore, more than 50% of LTSROC underwent tumor debulking surgery for the first recurrent tumor with or without chemotherapy. Conclusion: RFI of 1 year or longer and negative ascites cytology in the initial surgery were identified as independent predictive factors for LTSROC.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Long-term survivor, Post-recurrence survival, Recurrent ovarian cancer
in
International Journal of Clinical Oncology
volume
27
issue
10
pages
9 pages
publisher
Springer
external identifiers
  • scopus:85135253841
  • pmid:35906336
ISSN
1341-9625
DOI
10.1007/s10147-022-02214-9
language
English
LU publication?
yes
id
0cf68255-8365-453a-a1cc-97c5b4dc3f4d
date added to LUP
2022-11-29 11:13:58
date last changed
2024-09-02 07:05:48
@article{0cf68255-8365-453a-a1cc-97c5b4dc3f4d,
  abstract     = {{<p>Background: The aim of the present study was to investigate the incidence and hallmarks of long-term survivors of recurrent ovarian carcinoma (LTSROC) in a large-scale retrospective cohort of patients from a multicenter study group. Methods: We performed a regional multicenter retrospective study between January 1986 and September 2021 using clinical data collected under the central pathological review system. Patients who underwent surgery for primary OC at diagnosis and developed recurrent tumors after the initial treatment were included. We defined LTSROC as patients who survived for 5 years or longer after initial tumor recurrence and examined factors affecting the long-term survival of ROC and outcomes of LTSROC. Results: We collected information on patients with malignant ovarian tumors and finally 657 of them that developed ROC were included in the study population. Sixty-eight (10.4%) patients were LTSROC while 399 (60.7%) were short-term survivors of recurrent ovarian carcinoma. In a multivariate logistic regression analysis, negative ascites cytology [odds ratio (OR) 1.865; 95% CI 1.026–3.393; p = 0.041] and a recurrence-free interval (RFI) of 1 year or longer (OR 2.896; 95% CI 1.546–5.425; p &lt; 0.001) were identified as independent factors associated with LTSROC. Approximately 80% of LTSROC presented with solitary recurrent tumors. Furthermore, more than 50% of LTSROC underwent tumor debulking surgery for the first recurrent tumor with or without chemotherapy. Conclusion: RFI of 1 year or longer and negative ascites cytology in the initial surgery were identified as independent predictive factors for LTSROC.</p>}},
  author       = {{Yoshihara, Masato and Mogi, Kazumasa and Kitami, Kazuhisa and Uno, Kaname and Iyoshi, Shohei and Tano, Sho and Fujimoto, Hiroki and Miyamoto, Emiri and Yoshikawa, Nobuhisa and Emoto, Ryo and Matsui, Shigeyuki and Kajiyama, Hiroaki}},
  issn         = {{1341-9625}},
  keywords     = {{Long-term survivor; Post-recurrence survival; Recurrent ovarian cancer}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{1660--1668}},
  publisher    = {{Springer}},
  series       = {{International Journal of Clinical Oncology}},
  title        = {{Who are the long-term survivors of recurrent ovarian carcinoma? : a retrospective analysis of a multicenter study}},
  url          = {{http://dx.doi.org/10.1007/s10147-022-02214-9}},
  doi          = {{10.1007/s10147-022-02214-9}},
  volume       = {{27}},
  year         = {{2022}},
}