Basal ganglia oscillations as biomarkers for targeting circuit dysfunction in Parkinson's disease
(2020) In Progress in Brain Research 252. p.525-557- Abstract
Oscillations are a naturally occurring phenomenon in highly interconnected dynamical systems. However, it is thought that excessive synchronized oscillations in brain circuits can be detrimental for many brain functions by disrupting neuronal information processing. Because synchronized basal ganglia oscillations are a hallmark of Parkinson's disease (PD), it has been suggested that aberrant rhythmic activity associated with symptoms of the disease could be used as a physiological biomarker to guide pharmacological and electrical neuromodulatory interventions. We here briefly review the various manifestations of basal ganglia oscillations observed in human subjects and in animal models of PD. In this context, we also review the evidence... (More)
Oscillations are a naturally occurring phenomenon in highly interconnected dynamical systems. However, it is thought that excessive synchronized oscillations in brain circuits can be detrimental for many brain functions by disrupting neuronal information processing. Because synchronized basal ganglia oscillations are a hallmark of Parkinson's disease (PD), it has been suggested that aberrant rhythmic activity associated with symptoms of the disease could be used as a physiological biomarker to guide pharmacological and electrical neuromodulatory interventions. We here briefly review the various manifestations of basal ganglia oscillations observed in human subjects and in animal models of PD. In this context, we also review the evidence supporting a pathophysiological role of different oscillations for the suppression of voluntary movements as well as for the induction of excessive motor activity. In light of these findings, it is discussed how oscillations could be used to guide a more precise targeting of dysfunctional circuits to obtain improved symptomatic treatment of PD.
(Less)
- author
- Petersson, Per LU ; Kühn, Andrea A. ; Neumann, Wolf Julian and Fuentes, Romulo
- organization
- publishing date
- 2020
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Hyperkinesia, Hypokinesia, Levodopa, LFP, Neuronal circuits, Neurophysiology, Non-motor symptoms
- host publication
- Recent Advances in Parkinson's Disease
- series title
- Progress in Brain Research
- volume
- 252
- pages
- 33 pages
- publisher
- Elsevier Science Publishers B.V.
- external identifiers
-
- scopus:85081972115
- pmid:32247374
- ISSN
- 1875-7855
- 0079-6123
- ISBN
- 978-0-444-64260-8
- DOI
- 10.1016/bs.pbr.2020.02.002
- language
- English
- LU publication?
- yes
- id
- 0d001d19-7889-479e-aa6f-cffddb174e64
- date added to LUP
- 2020-04-08 14:21:48
- date last changed
- 2024-04-03 04:25:55
@inbook{0d001d19-7889-479e-aa6f-cffddb174e64,
abstract = {{<p>Oscillations are a naturally occurring phenomenon in highly interconnected dynamical systems. However, it is thought that excessive synchronized oscillations in brain circuits can be detrimental for many brain functions by disrupting neuronal information processing. Because synchronized basal ganglia oscillations are a hallmark of Parkinson's disease (PD), it has been suggested that aberrant rhythmic activity associated with symptoms of the disease could be used as a physiological biomarker to guide pharmacological and electrical neuromodulatory interventions. We here briefly review the various manifestations of basal ganglia oscillations observed in human subjects and in animal models of PD. In this context, we also review the evidence supporting a pathophysiological role of different oscillations for the suppression of voluntary movements as well as for the induction of excessive motor activity. In light of these findings, it is discussed how oscillations could be used to guide a more precise targeting of dysfunctional circuits to obtain improved symptomatic treatment of PD.</p>}},
author = {{Petersson, Per and Kühn, Andrea A. and Neumann, Wolf Julian and Fuentes, Romulo}},
booktitle = {{Recent Advances in Parkinson's Disease}},
isbn = {{978-0-444-64260-8}},
issn = {{1875-7855}},
keywords = {{Hyperkinesia; Hypokinesia; Levodopa; LFP; Neuronal circuits; Neurophysiology; Non-motor symptoms}},
language = {{eng}},
pages = {{525--557}},
publisher = {{Elsevier Science Publishers B.V.}},
series = {{Progress in Brain Research}},
title = {{Basal ganglia oscillations as biomarkers for targeting circuit dysfunction in Parkinson's disease}},
url = {{http://dx.doi.org/10.1016/bs.pbr.2020.02.002}},
doi = {{10.1016/bs.pbr.2020.02.002}},
volume = {{252}},
year = {{2020}},
}