Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Ozonation of Sitagliptin : Removal Kinetics and Elucidation of Oxidative Transformation Products

Hermes, Nina ; Jewell, Kevin S. ; Falås, Per LU ; Lutze, Holger V. ; Wick, Arne and Ternes, Thomas A. (2020) In Environmental Science and Technology 54(17). p.10588-10598
Abstract

Due to the increasing use and high excretion rates, high quantities of the antidiabetic drug sitagliptin (STG) enter wastewater treatment plants (WWTPs). In conventional biological treatment, only a moderate removal was achieved, and thus, STG can be detected in WWTP effluents with concentrations in the higher ng/L range. Ozonation is a widely discussed technique for advanced wastewater treatment. In lab-scale experiments, STG showed pH-dependent removal kinetics with a maximum apparent rate constant of k ∼1 × 104 M-1 s-1 at pH ≥ 9. With an apparent rate constant of kO3 = (1.8 ± 0.7) × 103 M-1 s-1 at pH 8, STG can be considered to be readily degraded by ozonation of WWTP effluents. Ozone attacks the primary amine moiety of STG, leading... (More)

Due to the increasing use and high excretion rates, high quantities of the antidiabetic drug sitagliptin (STG) enter wastewater treatment plants (WWTPs). In conventional biological treatment, only a moderate removal was achieved, and thus, STG can be detected in WWTP effluents with concentrations in the higher ng/L range. Ozonation is a widely discussed technique for advanced wastewater treatment. In lab-scale experiments, STG showed pH-dependent removal kinetics with a maximum apparent rate constant of k ∼1 × 104 M-1 s-1 at pH ≥ 9. With an apparent rate constant of kO3 = (1.8 ± 0.7) × 103 M-1 s-1 at pH 8, STG can be considered to be readily degraded by ozonation of WWTP effluents. Ozone attacks the primary amine moiety of STG, leading to nitro-STG (TP 437) (the primary amine moiety is transformed into a nitro group). Furthermore, a diketone (TP 406) was formed, which can be further degraded by ozone. Lab-scale and pilot-scale experiments on ozonation of WWTP effluents confirmed that the ozone attack of STG was incomplete even at high ozone doses of 1.7 and 0.9 mg O3/mg DOC, respectively. These experiments confirmed that nitro-STG was formed as the main TP in the wastewater matrix. Two other TPs, TP 421c and TP 206b, were also detected, albeit with low intensities.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Environmental Science and Technology
volume
54
issue
17
pages
11 pages
publisher
The American Chemical Society (ACS)
external identifiers
  • pmid:32867484
  • scopus:85089959317
ISSN
0013-936X
DOI
10.1021/acs.est.0c01454
language
English
LU publication?
yes
id
0d118edc-b06f-40bd-8f80-dec2846f5a5b
date added to LUP
2020-09-24 18:25:14
date last changed
2024-05-01 16:43:05
@article{0d118edc-b06f-40bd-8f80-dec2846f5a5b,
  abstract     = {{<p>Due to the increasing use and high excretion rates, high quantities of the antidiabetic drug sitagliptin (STG) enter wastewater treatment plants (WWTPs). In conventional biological treatment, only a moderate removal was achieved, and thus, STG can be detected in WWTP effluents with concentrations in the higher ng/L range. Ozonation is a widely discussed technique for advanced wastewater treatment. In lab-scale experiments, STG showed pH-dependent removal kinetics with a maximum apparent rate constant of k ∼1 × 104 M-1 s-1 at pH ≥ 9. With an apparent rate constant of kO3 = (1.8 ± 0.7) × 103 M-1 s-1 at pH 8, STG can be considered to be readily degraded by ozonation of WWTP effluents. Ozone attacks the primary amine moiety of STG, leading to nitro-STG (TP 437) (the primary amine moiety is transformed into a nitro group). Furthermore, a diketone (TP 406) was formed, which can be further degraded by ozone. Lab-scale and pilot-scale experiments on ozonation of WWTP effluents confirmed that the ozone attack of STG was incomplete even at high ozone doses of 1.7 and 0.9 mg O3/mg DOC, respectively. These experiments confirmed that nitro-STG was formed as the main TP in the wastewater matrix. Two other TPs, TP 421c and TP 206b, were also detected, albeit with low intensities. </p>}},
  author       = {{Hermes, Nina and Jewell, Kevin S. and Falås, Per and Lutze, Holger V. and Wick, Arne and Ternes, Thomas A.}},
  issn         = {{0013-936X}},
  language     = {{eng}},
  month        = {{08}},
  number       = {{17}},
  pages        = {{10588--10598}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{Environmental Science and Technology}},
  title        = {{Ozonation of Sitagliptin : Removal Kinetics and Elucidation of Oxidative Transformation Products}},
  url          = {{http://dx.doi.org/10.1021/acs.est.0c01454}},
  doi          = {{10.1021/acs.est.0c01454}},
  volume       = {{54}},
  year         = {{2020}},
}