Lower spatial QRS-T angle rules out sustained ventricular arrhythmias in children with hypertrophic cardiomyopathy
(2017) In Cardiology in the Young 27(2). p.354-358- Abstract
Introduction: The spatial peaks QRS-T angle accurately distinguishes children with hypertrophic cardiomyopathy from their healthy counterparts. The spatial peaks QRS-T angle is also useful in risk stratification for ventricular arrhythmias. We hypothesised that the spatial peaks QRS-T angle would be useful for the prediction of ventricular arrhythmias in hypertrophic cardiomyopathy patients under 23 years of age. Methods: Corrected QT interval and spatial peaks QRS-T angles were retrospectively assessed in 133 paediatric hypertrophic cardiomyopathy patients (12.4±6.6 years) with versus without ventricular arrhythmias of 30 seconds or longer. Significance, positive/negative predictive values, and odds ratios were calculated based on... (More)
Introduction: The spatial peaks QRS-T angle accurately distinguishes children with hypertrophic cardiomyopathy from their healthy counterparts. The spatial peaks QRS-T angle is also useful in risk stratification for ventricular arrhythmias. We hypothesised that the spatial peaks QRS-T angle would be useful for the prediction of ventricular arrhythmias in hypertrophic cardiomyopathy patients under 23 years of age. Methods: Corrected QT interval and spatial peaks QRS-T angles were retrospectively assessed in 133 paediatric hypertrophic cardiomyopathy patients (12.4±6.6 years) with versus without ventricular arrhythmias of 30 seconds or longer. Significance, positive/negative predictive values, and odds ratios were calculated based on receiver operating characteristic curve cut-off values. Results: In total, 10 patients with ventricular arrhythmias were identified. Although the corrected QT interval did not differentiate those with versus without ventricular arrhythmias, the spatial peaks QRS-T angle did (151.4±19.0 versus 116.8±42.6 degrees, respectively, p<0.001). At an optimal cut-off value (124.1 degrees), the positive and negative predictive values of the spatial peaks QRS-T angle were 15.4 and 100.0%, respectively, with an odds ratio of 25.9 (95% CI 1.5–452.2). Conclusion: In children with hypertrophic cardiomyopathy, the spatial peaks QRS-T angle is associated with ventricular arrhythmia burden with high negative predictive value and odds ratio.
(Less)
- author
- organization
- publishing date
- 2017
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- hypertrophic cardiomyopathy, prediction, QTc, Spatial QRS-T angle, ventricular arrhythmias
- in
- Cardiology in the Young
- volume
- 27
- issue
- 2
- pages
- 5 pages
- publisher
- Cambridge University Press
- external identifiers
-
- scopus:84973917046
- pmid:27246458
- wos:000398111200019
- ISSN
- 1047-9511
- DOI
- 10.1017/S1047951116000640
- language
- English
- LU publication?
- yes
- id
- 0d1e0090-d7a1-480f-b528-0ae45ec946f9
- date added to LUP
- 2017-01-27 08:26:13
- date last changed
- 2025-01-12 20:20:23
@article{0d1e0090-d7a1-480f-b528-0ae45ec946f9, abstract = {{<p>Introduction: The spatial peaks QRS-T angle accurately distinguishes children with hypertrophic cardiomyopathy from their healthy counterparts. The spatial peaks QRS-T angle is also useful in risk stratification for ventricular arrhythmias. We hypothesised that the spatial peaks QRS-T angle would be useful for the prediction of ventricular arrhythmias in hypertrophic cardiomyopathy patients under 23 years of age. Methods: Corrected QT interval and spatial peaks QRS-T angles were retrospectively assessed in 133 paediatric hypertrophic cardiomyopathy patients (12.4±6.6 years) with versus without ventricular arrhythmias of 30 seconds or longer. Significance, positive/negative predictive values, and odds ratios were calculated based on receiver operating characteristic curve cut-off values. Results: In total, 10 patients with ventricular arrhythmias were identified. Although the corrected QT interval did not differentiate those with versus without ventricular arrhythmias, the spatial peaks QRS-T angle did (151.4±19.0 versus 116.8±42.6 degrees, respectively, p<0.001). At an optimal cut-off value (124.1 degrees), the positive and negative predictive values of the spatial peaks QRS-T angle were 15.4 and 100.0%, respectively, with an odds ratio of 25.9 (95% CI 1.5–452.2). Conclusion: In children with hypertrophic cardiomyopathy, the spatial peaks QRS-T angle is associated with ventricular arrhythmia burden with high negative predictive value and odds ratio.</p>}}, author = {{Cortez, Daniel and Sharma, Nandita and Cavanaugh, Jean and Tuozo, Froilan and Derk, Gwendolyn and Lundberg, Emily and Weiner, Keith and Kiciman, Nafiz and Alejos, Juan and Landeck, Bruce and Aboulhosn, Jamil and Miyamoto, Shelley and McCanta, Anthony C. and Batra, Anjan S.}}, issn = {{1047-9511}}, keywords = {{hypertrophic cardiomyopathy; prediction; QTc; Spatial QRS-T angle; ventricular arrhythmias}}, language = {{eng}}, number = {{2}}, pages = {{354--358}}, publisher = {{Cambridge University Press}}, series = {{Cardiology in the Young}}, title = {{Lower spatial QRS-T angle rules out sustained ventricular arrhythmias in children with hypertrophic cardiomyopathy}}, url = {{http://dx.doi.org/10.1017/S1047951116000640}}, doi = {{10.1017/S1047951116000640}}, volume = {{27}}, year = {{2017}}, }