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Lower spatial QRS-T angle rules out sustained ventricular arrhythmias in children with hypertrophic cardiomyopathy

Cortez, Daniel LU ; Sharma, Nandita; Cavanaugh, Jean; Tuozo, Froilan; Derk, Gwendolyn; Lundberg, Emily; Weiner, Keith; Kiciman, Nafiz; Alejos, Juan and Landeck, Bruce, et al. (2017) In Cardiology in the Young 27(2). p.354-358
Abstract

Introduction: The spatial peaks QRS-T angle accurately distinguishes children with hypertrophic cardiomyopathy from their healthy counterparts. The spatial peaks QRS-T angle is also useful in risk stratification for ventricular arrhythmias. We hypothesised that the spatial peaks QRS-T angle would be useful for the prediction of ventricular arrhythmias in hypertrophic cardiomyopathy patients under 23 years of age. Methods: Corrected QT interval and spatial peaks QRS-T angles were retrospectively assessed in 133 paediatric hypertrophic cardiomyopathy patients (12.4±6.6 years) with versus without ventricular arrhythmias of 30 seconds or longer. Significance, positive/negative predictive values, and odds ratios were calculated based on... (More)

Introduction: The spatial peaks QRS-T angle accurately distinguishes children with hypertrophic cardiomyopathy from their healthy counterparts. The spatial peaks QRS-T angle is also useful in risk stratification for ventricular arrhythmias. We hypothesised that the spatial peaks QRS-T angle would be useful for the prediction of ventricular arrhythmias in hypertrophic cardiomyopathy patients under 23 years of age. Methods: Corrected QT interval and spatial peaks QRS-T angles were retrospectively assessed in 133 paediatric hypertrophic cardiomyopathy patients (12.4±6.6 years) with versus without ventricular arrhythmias of 30 seconds or longer. Significance, positive/negative predictive values, and odds ratios were calculated based on receiver operating characteristic curve cut-off values. Results: In total, 10 patients with ventricular arrhythmias were identified. Although the corrected QT interval did not differentiate those with versus without ventricular arrhythmias, the spatial peaks QRS-T angle did (151.4±19.0 versus 116.8±42.6 degrees, respectively, p<0.001). At an optimal cut-off value (124.1 degrees), the positive and negative predictive values of the spatial peaks QRS-T angle were 15.4 and 100.0%, respectively, with an odds ratio of 25.9 (95% CI 1.5–452.2). Conclusion: In children with hypertrophic cardiomyopathy, the spatial peaks QRS-T angle is associated with ventricular arrhythmia burden with high negative predictive value and odds ratio.

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organization
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type
Contribution to journal
publication status
published
subject
keywords
hypertrophic cardiomyopathy, prediction, QTc, Spatial QRS-T angle, ventricular arrhythmias
in
Cardiology in the Young
volume
27
issue
2
pages
5 pages
publisher
Cambridge University Press
external identifiers
  • scopus:84973917046
  • wos:000398111200019
ISSN
1047-9511
DOI
10.1017/S1047951116000640
language
English
LU publication?
yes
id
0d1e0090-d7a1-480f-b528-0ae45ec946f9
date added to LUP
2017-01-27 08:26:13
date last changed
2018-01-07 11:47:06
@article{0d1e0090-d7a1-480f-b528-0ae45ec946f9,
  abstract     = {<p>Introduction: The spatial peaks QRS-T angle accurately distinguishes children with hypertrophic cardiomyopathy from their healthy counterparts. The spatial peaks QRS-T angle is also useful in risk stratification for ventricular arrhythmias. We hypothesised that the spatial peaks QRS-T angle would be useful for the prediction of ventricular arrhythmias in hypertrophic cardiomyopathy patients under 23 years of age. Methods: Corrected QT interval and spatial peaks QRS-T angles were retrospectively assessed in 133 paediatric hypertrophic cardiomyopathy patients (12.4±6.6 years) with versus without ventricular arrhythmias of 30 seconds or longer. Significance, positive/negative predictive values, and odds ratios were calculated based on receiver operating characteristic curve cut-off values. Results: In total, 10 patients with ventricular arrhythmias were identified. Although the corrected QT interval did not differentiate those with versus without ventricular arrhythmias, the spatial peaks QRS-T angle did (151.4±19.0 versus 116.8±42.6 degrees, respectively, p&lt;0.001). At an optimal cut-off value (124.1 degrees), the positive and negative predictive values of the spatial peaks QRS-T angle were 15.4 and 100.0%, respectively, with an odds ratio of 25.9 (95% CI 1.5–452.2). Conclusion: In children with hypertrophic cardiomyopathy, the spatial peaks QRS-T angle is associated with ventricular arrhythmia burden with high negative predictive value and odds ratio.</p>},
  author       = {Cortez, Daniel and Sharma, Nandita and Cavanaugh, Jean and Tuozo, Froilan and Derk, Gwendolyn and Lundberg, Emily and Weiner, Keith and Kiciman, Nafiz and Alejos, Juan and Landeck, Bruce and Aboulhosn, Jamil and Miyamoto, Shelley and McCanta, Anthony C. and Batra, Anjan S.},
  issn         = {1047-9511},
  keyword      = {hypertrophic cardiomyopathy,prediction,QTc,Spatial QRS-T angle,ventricular arrhythmias},
  language     = {eng},
  number       = {2},
  pages        = {354--358},
  publisher    = {Cambridge University Press},
  series       = {Cardiology in the Young},
  title        = {Lower spatial QRS-T angle rules out sustained ventricular arrhythmias in children with hypertrophic cardiomyopathy},
  url          = {http://dx.doi.org/10.1017/S1047951116000640},
  volume       = {27},
  year         = {2017},
}