Carotid Intima-Media Thickness, Systemic Inflammation, and Incidence of Heart Failure Hospitalizations.
Engström, Gunnar LU ; Melander, Olle LU
and Hedblad, Bo
LU
(2009)
In Arteriosclerosis, Thrombosis and Vascular Biology
29.
p.1691-1695
- Abstract
- OBJECTIVE: This study explored the relationships between carotid intima-media thickness (IMT), plasma levels of C-reactive protein (CRP), and incidence of heart failure hospitalizations. METHODS AND RESULTS: Men and women from the general population (n=4691), without history of myocardial infarction or stroke, were examined. Incidence of hospitalizations attributable to heart failure was studied over a mean follow-up of 13 years. A total of 75 subjects were hospitalized with a primary diagnosis of heart failure. Adjusted for risk factors, the hazards ratios (95% CI) were 1.00, 0.98 (0.36 to 2.7), 1.9 (0.80 to 4.6), and 2.7 (1.1 to 6.2), respectively, for the 1st, 2nd, 3rd, and 4th quartiles of IMT (P for trend=0.003). The HR associated... (More)
- OBJECTIVE: This study explored the relationships between carotid intima-media thickness (IMT), plasma levels of C-reactive protein (CRP), and incidence of heart failure hospitalizations. METHODS AND RESULTS: Men and women from the general population (n=4691), without history of myocardial infarction or stroke, were examined. Incidence of hospitalizations attributable to heart failure was studied over a mean follow-up of 13 years. A total of 75 subjects were hospitalized with a primary diagnosis of heart failure. Adjusted for risk factors, the hazards ratios (95% CI) were 1.00, 0.98 (0.36 to 2.7), 1.9 (0.80 to 4.6), and 2.7 (1.1 to 6.2), respectively, for the 1st, 2nd, 3rd, and 4th quartiles of IMT (P for trend=0.003). The HR associated with CRP levels >/=3 mg/L (versus <1 mg/L) was 2.0 (95% CI: 1.06 to 3.9) after adjustments for risk factors. There was a significant interaction between IMT and CRP on heart failure incidence (P=0.028). Subjects with CRP >/=3 mg/L and IMT in the 4th quartile had an adjusted HR of 3.7 (1.9 to 7.1) compared to those with CRP <3 mg/L and IMT in quartile 1 to 3. CONCLUSIONS: High IMT and high CRP are both independent risk factors for incidence of heart failure requiring hospitalization. The joint exposure to both risk factors substantially increases the risk. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1470219
- author
- Engström, Gunnar
LU
; Melander, Olle
LU
and Hedblad, Bo
LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Arteriosclerosis, Thrombosis and Vascular Biology
- volume
- 29
- pages
- 1691 - 1695
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000269848600045
- pmid:19644052
- scopus:70349567634
- pmid:19644052
- ISSN
- 1524-4636
- DOI
- 10.1161/ATVBAHA.109.193490
- language
- English
- LU publication?
- yes
- id
- 0d77f720-4e9f-4298-b427-abfefe1e1526 (old id 1470219)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19644052?dopt=Abstract
- date added to LUP
- 2016-04-04 08:28:16
- date last changed
- 2024-01-12 04:52:10
@article{0d77f720-4e9f-4298-b427-abfefe1e1526,
abstract = {{OBJECTIVE: This study explored the relationships between carotid intima-media thickness (IMT), plasma levels of C-reactive protein (CRP), and incidence of heart failure hospitalizations. METHODS AND RESULTS: Men and women from the general population (n=4691), without history of myocardial infarction or stroke, were examined. Incidence of hospitalizations attributable to heart failure was studied over a mean follow-up of 13 years. A total of 75 subjects were hospitalized with a primary diagnosis of heart failure. Adjusted for risk factors, the hazards ratios (95% CI) were 1.00, 0.98 (0.36 to 2.7), 1.9 (0.80 to 4.6), and 2.7 (1.1 to 6.2), respectively, for the 1st, 2nd, 3rd, and 4th quartiles of IMT (P for trend=0.003). The HR associated with CRP levels >/=3 mg/L (versus <1 mg/L) was 2.0 (95% CI: 1.06 to 3.9) after adjustments for risk factors. There was a significant interaction between IMT and CRP on heart failure incidence (P=0.028). Subjects with CRP >/=3 mg/L and IMT in the 4th quartile had an adjusted HR of 3.7 (1.9 to 7.1) compared to those with CRP <3 mg/L and IMT in quartile 1 to 3. CONCLUSIONS: High IMT and high CRP are both independent risk factors for incidence of heart failure requiring hospitalization. The joint exposure to both risk factors substantially increases the risk.}},
author = {{Engström, Gunnar and Melander, Olle and Hedblad, Bo}},
issn = {{1524-4636}},
language = {{eng}},
pages = {{1691--1695}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Arteriosclerosis, Thrombosis and Vascular Biology}},
title = {{Carotid Intima-Media Thickness, Systemic Inflammation, and Incidence of Heart Failure Hospitalizations.}},
url = {{http://dx.doi.org/10.1161/ATVBAHA.109.193490}},
doi = {{10.1161/ATVBAHA.109.193490}},
volume = {{29}},
year = {{2009}},
}