Advanced

N-acetyltransferase 2 Phenotype, Occupation, and Bladder Cancer Risk: Results from the EPIC Cohort

Pesch, Beate; Gawrych, Katarzyna; Rabstein, Sylvia; Weiss, Tobias; Casjens, Swaantje; Rihs, Hans-Peter; Ding, Hui; Angerer, Juergen; Illig, Thomas and Klopp, Norman, et al. (2013) In Cancer Epidemiology Biomarkers & Prevention 22(11). p.2055-2065
Abstract
Background: An association between N-acetyltransferase 2 (NAT2) slow acetylation and bladder cancer has been consistently observed in epidemiologic studies. However, evidence has been mainly derived from case-control studies and was sparse from cohort studies. We evaluated the association between NAT2 slow acetylation and bladder cancer in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition. Methods: Exposure to aromatic amines and polycyclic aromatic hydrocarbons (PAH) could be assessed for 754 cases and 833 controls for whom occupational information was documented. A semiquantitative job-exposure matrix was applied to at-risk occupations to estimate the exposure as low, medium, or high based on... (More)
Background: An association between N-acetyltransferase 2 (NAT2) slow acetylation and bladder cancer has been consistently observed in epidemiologic studies. However, evidence has been mainly derived from case-control studies and was sparse from cohort studies. We evaluated the association between NAT2 slow acetylation and bladder cancer in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition. Methods: Exposure to aromatic amines and polycyclic aromatic hydrocarbons (PAH) could be assessed for 754 cases and 833 controls for whom occupational information was documented. A semiquantitative job-exposure matrix was applied to at-risk occupations to estimate the exposure as low, medium, or high based on tertiles of the distribution of the exposure score in controls. Using a comprehensive genotyping, NAT2 acetylation status could be categorized from 6-single-nucleotide polymorphism genotypes as slow or fast in 607 cases and 695 controls with DNA from archived blood samples. Results: Occupational exposure to aromatic amines and PAH was associated with an increased bladder cancer risk [upper tertile of the distribution of the exposure score: OR = 1.37; 95% confidence interval (CI), 1.02-1.84, and OR = 1.50; 95% CI, 1.09-2.05, respectively]. NAT2 slow acetylation did not modify these risk estimates and was not itself associated with bladder cancer risk (OR = 1.02; 95% CI, 0.81-1.29). Conclusions: These findings confirm established or suspected occupational risk factors but not the anticipated role of NAT2 slow acetylation in bladder cancer. No interaction was detected between NAT2 and any exposure of interest, including smoking. Impact: Genetic testing for NAT2 would be inappropriate in occupational settings. (C) 2013 AACR. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cancer Epidemiology Biomarkers & Prevention
volume
22
issue
11
pages
2055 - 2065
publisher
American Association for Cancer Research
external identifiers
  • wos:000327726800015
  • scopus:84887287349
ISSN
1538-7755
DOI
10.1158/1055-9965.EPI-13-0119-T
language
English
LU publication?
yes
id
0dd16c6e-e0a1-40b6-a573-4ace7e21b55a (old id 4272462)
date added to LUP
2014-02-10 12:20:27
date last changed
2019-02-20 07:03:22
@article{0dd16c6e-e0a1-40b6-a573-4ace7e21b55a,
  abstract     = {Background: An association between N-acetyltransferase 2 (NAT2) slow acetylation and bladder cancer has been consistently observed in epidemiologic studies. However, evidence has been mainly derived from case-control studies and was sparse from cohort studies. We evaluated the association between NAT2 slow acetylation and bladder cancer in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition. Methods: Exposure to aromatic amines and polycyclic aromatic hydrocarbons (PAH) could be assessed for 754 cases and 833 controls for whom occupational information was documented. A semiquantitative job-exposure matrix was applied to at-risk occupations to estimate the exposure as low, medium, or high based on tertiles of the distribution of the exposure score in controls. Using a comprehensive genotyping, NAT2 acetylation status could be categorized from 6-single-nucleotide polymorphism genotypes as slow or fast in 607 cases and 695 controls with DNA from archived blood samples. Results: Occupational exposure to aromatic amines and PAH was associated with an increased bladder cancer risk [upper tertile of the distribution of the exposure score: OR = 1.37; 95% confidence interval (CI), 1.02-1.84, and OR = 1.50; 95% CI, 1.09-2.05, respectively]. NAT2 slow acetylation did not modify these risk estimates and was not itself associated with bladder cancer risk (OR = 1.02; 95% CI, 0.81-1.29). Conclusions: These findings confirm established or suspected occupational risk factors but not the anticipated role of NAT2 slow acetylation in bladder cancer. No interaction was detected between NAT2 and any exposure of interest, including smoking. Impact: Genetic testing for NAT2 would be inappropriate in occupational settings. (C) 2013 AACR.},
  author       = {Pesch, Beate and Gawrych, Katarzyna and Rabstein, Sylvia and Weiss, Tobias and Casjens, Swaantje and Rihs, Hans-Peter and Ding, Hui and Angerer, Juergen and Illig, Thomas and Klopp, Norman and Bueno-de-Mesquita, Bas and Ros, Martine M. and Kaaks, Rudolf and Chang-Claude, Jenny and Roswall, Nina and Tjonneland, Anne and Overvad, Kim and Clavel-Chapelon, Francoise and Boutron-Ruault, Marie-Christine and Dossus, Laure and Boeing, Heiner and Weikert, Steffen and Trichopoulos, Dimitrios and Palli, Domenico and Sieri, Sabina and Tumino, Rosario and Panico, Salvatore and Ramon Quiros, Jose and Gonzalez, Carlos and Jose Sanchez, Maria and Dorronsoro, Miren and Navarro, Carmen and Barricarte, Aurelio and Ljungberg, Boerje and Johansson, Mattias and Ulmert, David and Ehrnström, Roy and Khaw, Kay-Tee and Wareham, Nick and Key, Timothy J. and Ferrari, Pietro and Romieu, Isabelle and Riboli, Elio and Bruening, Thomas and Vineis, Paolo},
  issn         = {1538-7755},
  language     = {eng},
  number       = {11},
  pages        = {2055--2065},
  publisher    = {American Association for Cancer Research},
  series       = {Cancer Epidemiology Biomarkers & Prevention},
  title        = {N-acetyltransferase 2 Phenotype, Occupation, and Bladder Cancer Risk: Results from the EPIC Cohort},
  url          = {http://dx.doi.org/10.1158/1055-9965.EPI-13-0119-T},
  volume       = {22},
  year         = {2013},
}