Dissection of the genetic complexity of arthritis using animal models.
(2006) In Immunology Letters 103(2). p.86-91- Abstract
- Rheumatoid arthritis (RA) is a chronic inflammatory disease directed towards peripheral joints. As all common diseases it is associated with several genes and a multitude of environmental factors. In addition, in similarity with most other complex diseases, it is defined only on the basis of clinical signs and symptoms, it is therefore more properly classified as a syndrome rather than a distinct disease entity.
This complexity of RA has led to difficulties in finding the underlying genes. In spite of large efforts it is still only the MHC class II region that reaches genome wide significance in confirmed studies. However, this has been known for decades and we are still unable to conclusively identify the underlying... (More) - Rheumatoid arthritis (RA) is a chronic inflammatory disease directed towards peripheral joints. As all common diseases it is associated with several genes and a multitude of environmental factors. In addition, in similarity with most other complex diseases, it is defined only on the basis of clinical signs and symptoms, it is therefore more properly classified as a syndrome rather than a distinct disease entity.
This complexity of RA has led to difficulties in finding the underlying genes. In spite of large efforts it is still only the MHC class II region that reaches genome wide significance in confirmed studies. However, this has been known for decades and we are still unable to conclusively identify the underlying gene/s. We hypothesize that an MHC class II gene is involved and although we have detailed knowledge on both structure and function we do not know its possible pathogenic role in RA.
In this review I will argue for the usefulness of animal models as a tool to identify genes and pathways associated with disease. The examples to be discussed are genes controlling the oxidative burst pathways and MHC class II genes. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/150311
- author
- Holmdahl, Rikard LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- MHC class II, Animal models, Genetics, Arthritis, Oxidative burst
- in
- Immunology Letters
- volume
- 103
- issue
- 2
- pages
- 86 - 91
- publisher
- Elsevier
- external identifiers
-
- wos:000235700000002
- scopus:31544452514
- pmid:16413614
- ISSN
- 0165-2478
- DOI
- 10.1016/j.imlet.2005.10.025
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Medical Inflammation Research (013212019)
- id
- 0e2dc0b5-f613-42dd-b6bb-758e5ccee947 (old id 150311)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16413614&dopt=Abstract
- date added to LUP
- 2016-04-01 11:35:36
- date last changed
- 2022-01-26 07:20:46
@article{0e2dc0b5-f613-42dd-b6bb-758e5ccee947,
abstract = {{Rheumatoid arthritis (RA) is a chronic inflammatory disease directed towards peripheral joints. As all common diseases it is associated with several genes and a multitude of environmental factors. In addition, in similarity with most other complex diseases, it is defined only on the basis of clinical signs and symptoms, it is therefore more properly classified as a syndrome rather than a distinct disease entity.<br/><br>
<br/><br>
This complexity of RA has led to difficulties in finding the underlying genes. In spite of large efforts it is still only the MHC class II region that reaches genome wide significance in confirmed studies. However, this has been known for decades and we are still unable to conclusively identify the underlying gene/s. We hypothesize that an MHC class II gene is involved and although we have detailed knowledge on both structure and function we do not know its possible pathogenic role in RA.<br/><br>
<br/><br>
In this review I will argue for the usefulness of animal models as a tool to identify genes and pathways associated with disease. The examples to be discussed are genes controlling the oxidative burst pathways and MHC class II genes.}},
author = {{Holmdahl, Rikard}},
issn = {{0165-2478}},
keywords = {{MHC class II; Animal models; Genetics; Arthritis; Oxidative burst}},
language = {{eng}},
number = {{2}},
pages = {{86--91}},
publisher = {{Elsevier}},
series = {{Immunology Letters}},
title = {{Dissection of the genetic complexity of arthritis using animal models.}},
url = {{https://lup.lub.lu.se/search/files/2553102/625262.pdf}},
doi = {{10.1016/j.imlet.2005.10.025}},
volume = {{103}},
year = {{2006}},
}