Reduction of MS-related scotomata by a new class of potassium channel blockers from ruta graveolens
(1993) In Neuro-Ophthalmology 13(4). p.191-198- Abstract
The effects of the medicinal plant rue (Ruta graveolens L.) on MS-related visual-field defects was tested. In five of nine patients the scotomata were reduced by a single dose of an aqueous extract of 3 g of the drug; the effect was reversible, appearing after only about two hours and lasting for one to two days. There was no detectable action in four patients. In no case were undesirable side effects observed. The problems associated with generalizing and evaluating both clinical findings in MS and the efficacy of treatment are discussed. The observed action of Ruta graveolens is ascribed to the potassium channel blockers the plant contains. The authors have identified these substances as methoxy-substituted psoralens.
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- author
- Bohuslavizki, Karl H. ; Hinck-Kneip, Christiane ; Kneip, Axel ; Koppenhöfer, Eilhard and Reimers, Arne LU
- publishing date
- 1993
- type
- Contribution to journal
- publication status
- published
- keywords
- Multiple sclerosis, Potassium channel blockers, Psoralens, Scotomata
- in
- Neuro-Ophthalmology
- volume
- 13
- issue
- 4
- pages
- 191 - 198
- publisher
- Taylor & Francis
- external identifiers
-
- scopus:0027367598
- ISSN
- 0165-8107
- DOI
- 10.3109/01658109309038150
- language
- English
- LU publication?
- no
- id
- 0e2df8ba-54bc-41cd-ae86-05e57914e7c6
- date added to LUP
- 2024-08-31 15:00:12
- date last changed
- 2024-09-02 08:30:35
@article{0e2df8ba-54bc-41cd-ae86-05e57914e7c6, abstract = {{<p>The effects of the medicinal plant rue (Ruta graveolens L.) on MS-related visual-field defects was tested. In five of nine patients the scotomata were reduced by a single dose of an aqueous extract of 3 g of the drug; the effect was reversible, appearing after only about two hours and lasting for one to two days. There was no detectable action in four patients. In no case were undesirable side effects observed. The problems associated with generalizing and evaluating both clinical findings in MS and the efficacy of treatment are discussed. The observed action of Ruta graveolens is ascribed to the potassium channel blockers the plant contains. The authors have identified these substances as methoxy-substituted psoralens.</p>}}, author = {{Bohuslavizki, Karl H. and Hinck-Kneip, Christiane and Kneip, Axel and Koppenhöfer, Eilhard and Reimers, Arne}}, issn = {{0165-8107}}, keywords = {{Multiple sclerosis; Potassium channel blockers; Psoralens; Scotomata}}, language = {{eng}}, number = {{4}}, pages = {{191--198}}, publisher = {{Taylor & Francis}}, series = {{Neuro-Ophthalmology}}, title = {{Reduction of MS-related scotomata by a new class of potassium channel blockers from ruta graveolens}}, url = {{http://dx.doi.org/10.3109/01658109309038150}}, doi = {{10.3109/01658109309038150}}, volume = {{13}}, year = {{1993}}, }